Ultrathin water layers on mannosylated gold nanoparticles

• Maiara A. Iriarte Alonso,
• Jorge H. Melillo,
• Silvina Cerveny,
• Yujin Tong and
• Alexander M. Bittner

Beilstein J. Nanotechnol. 2025, 16, 2183–2198, doi:10.3762/bjnano.16.151

• nanoparticle systems, one functionalized with an oligo(ethylene glycol) ligand, and one functionalized with a mixture of the same with a dimannoside ligand. The dimannoside ligand was chosen to mimic the surface chemistry of viral spike proteins. We characterized the particles by electron microscopy, dynamic

• high and the shape cannot be identical (hemagglutinin is roughly a triangular 7 nm prism of 15 nm length), the size is in the typical NP range, and a dense coating with oligomannoside should mimic surface physics. Accordingly, we note that the adsorption of AuNPs on surfaces would mimic the survival of

• and stability in solution, in terms of hydrodynamic diameter and NP surface charge, respectively. Spectroscopy techniques were used to analyze the chemical composition of the organic ligands locally. We used FTIR for the molecular fingerprint infrared region to find the characteristic peaks of the

Missing links in nanomaterials research impacting productivity and perceptions

• Santosh K. Tiwari and
• Nannan Wang

Beilstein J. Nanotechnol. 2025, 16, 2168–2176, doi:10.3762/bjnano.16.149

• Santosh K. Tiwari Nannan Wang Centre for New Materials and Surface Engineering, Department of Chemistry, NMAM Institute of Technology (NMAMIT), Nitte (Deemed to be University), Nitte 574110, Karnataka, India State Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite

• nanomaterials becomes a tedious and expensive task, often more so than for advanced bulk materials. It is indispensable to acknowledge that even after detailed characterization, warranting that even 90% of the nanoparticles have uniform size and identical surface characteristics is difficult. This is largely

• due to the inherent instability of 0D, 1D, and 2D nanomaterials [23]. That is why, in most cases, nanomaterials require a specific medium and controlled environment for stability. In the same line, due their high surface energy, large surface area, and small size, nanomaterials naturally tend to

Microplastic pollution in Himalayan lakes: assessment, risks, and sustainable remediation strategies

• Sameeksha Rawat,
• S. M. Tauseef and
• Madhuben Sharma

Beilstein J. Nanotechnol. 2025, 16, 2144–2167, doi:10.3762/bjnano.16.148

• due to surface runoff from tourist activities, plastic trash, and unregulated effluent. For instance, Jain et al. reported a MP density of 110–370 particles/m3 in the Nainital Lake, Uttarakhand, which was highest during the tourist season. The outcomes confirm that human accessibility and lake

• influence the food web structure [4]. For instance, a study in Dal Lake recorded MP concentrations of 2450 particles/m2 in sediments and 9.8 particles/L in surface water [11], indicating significant ecological exposure. 3.3 Global comparison with other sensitive aquatic ecosystems Across the globe, MPs have

• . provided a comprehensive historical analysis of water and emerging pollutants, specifically microplastics, in the Indian Himalayas, highlighting how such pollutants have progressively affected surface and groundwater as a result of unregulated use of plastic and a lack of waste management infrastructure

Electron transport through nanoscale multilayer graphene and hexagonal boron nitride junctions

• Aleksandar Staykov and
• Takaya Fujisaki

Beilstein J. Nanotechnol. 2025, 16, 2132–2143, doi:10.3762/bjnano.16.147

• Pt(111) surface, graphene, and h-BH using the QuantumWise ATK interface builder. The process involves strain minimization in the lattice mismatch by symmetry multiplication of the unit cells. The junctions shown in Figure 4 and Figure 5 have 1.06% distributed strain over Pt and graphene or h-BN. The

• distance between graphene or h-BN and the Pt surface is set to 3.2 Å. The central region includes six layers of the source electrode and six layers of the drain electrode. The electrode supercells are 3 × 3 × 3 Pt unit cells. The (I/V) curves are computed using the methodology described in Equations 2–10

• energy of pristine graphene and graphene with Stone–Wales defect to the Pt(111) surface. In those calculations, we use two graphene layers with a 4 × 4 × 1 supercell. The Stone–Wales defect is in the layer facing the Pt surface. Pt is modeled by six layers where the bottom three layers have the atomic

Quality by design optimization of microemulsions for topical delivery of Passiflora setacea seed oil

• Daniel T. Pereira,
• Douglas Dourado,
• Danielle T. Freire,
• Dayanne L. Porto,
• Cícero F. S. Aragão,
• Myla L. de Souza,
• Guilherme R. S. de Araujo,
• Ana Maria Costa,
• Wógenes N. Oliveira,
• Anne Sapin-Minet,
• Éverton N. Alencar and
• Eryvaldo Sócrates T. Egito

Beilstein J. Nanotechnol. 2025, 16, 2116–2131, doi:10.3762/bjnano.16.146

• response surface plots for each response, as shown in Figure 6. The axes were selected based on the most significant interactions identified through ANOVA, while the third factor was held constant at its central level. The resulting plots provide a visual representation of the individual and interactive

• other components such as NaCMC and vitamin E [44][45]. Surface tension The surface tension of the microemulsion was characterized through six replicates, yielding an average value of 40.27 ± 0.22 mN·m−1. Similar surface tension values have been reported for microemulsions in the literature [46][47

• ]. This range is considerably favorable for topical formulations, as lower surface tension enhances spreadability and promotes interaction with the stratum corneum and its lipidic barrier. Due to instrumental limitations associated with the high viscosity resulting from NaCMC addition, the surface tension

Rapid synthesis of highly monodisperse AgSbS₂ nanocrystals: unveiling multifaceted activities in cancer therapy, antibacterial strategies, and antioxidant defense

• Funda Ulusu,
• Adem Sarilmaz,
• Yakup Ulusu,
• Faruk Ozel and
• Mahmut Kus

Beilstein J. Nanotechnol. 2025, 16, 2105–2115, doi:10.3762/bjnano.16.145

• mg/mL) NCs were placed on the surface of MHA plates inoculated with 100 μL of a suspension comprising 108–109 CFU/mL of microorganisms and incubated for 24 h at 37 °C. In addition, ampicillin (10 mg/disc) and 10% DMSO were used as control for comparative effect. The zone of inhibition (ZOI) was

• in this study, it is generally accepted that the surface charge of NCs plays a critical role in their colloidal stability, dispersion behavior, and biological interactions [22][32]. In cubic cuboargyrite phase, there are 14 polyhedra with antimony and silver at the center (Figure 1c). Herein, a

• infections dominated by this pathogen. However, their relatively weaker activity against E. coli and B. subtilis suggests that optimization may be necessary to broaden their spectrum through surface modification, particle size reduction, or combination with other antibacterial agents. Cytotoxicity of AgSbS2

Toward clinical translation of carbon nanomaterials in anticancer drug delivery: the need for standardisation

• Michał Bartkowski,
• Francesco Calzaferri and
• Silvia Giordani

Beilstein J. Nanotechnol. 2025, 16, 2092–2104, doi:10.3762/bjnano.16.144

• nanotubes, and carbon dots, have attracted considerable interest as nanocarriers for drug delivery due to their unique physicochemical properties. Their high surface area, biocompatibility, and modifiable surface chemistry make them highly attractive for a range of biomedical applications. However, concerns

• nanomaterials (CNMs) have been largely developed as nanocarriers for drug delivery due to their biocompatibility, high surface area, tuneable physicochemical properties, and targeting capabilities [13][14]. However, CNMs also present a subset of challenges, including toxicity concerns, expensive and time

• affairs. Achieving these key milestones is critical to developing a safe and effective drug delivery system that can improve the treatment of cancer. The process begins with the synthesis of CNMs tailored to specific size and surface chemistry requirements, using methods such as chemical vapour deposition

Multifrequency AFM integrating PeakForce tapping and higher eigenmodes for heterogeneous surface characterization

• Yanping Wei,
• Jiafeng Shen,
• Yirong Yao,
• Xuke Li,
• Ming Li and
• Peiling Ke

Beilstein J. Nanotechnol. 2025, 16, 2077–2085, doi:10.3762/bjnano.16.142

• . Keywords: atomic force microscopy (AFM); high eigenmodes; multifrequency AFM; nanoscale material analysis; surface characterization; Introduction Atomic force microscopy (AFM) has become an indispensable tool for characterizing the morphology and surface properties of materials at the micro- and the

• interacting intermittently with the sample surface. By monitoring and controlling the cantilever’s amplitude and phase, topographical and phase images can be generated, providing insights into material properties and enabling the differentiation of regions or components within heterogeneous samples [7][8][9

• overcome these challenges. This configuration harnesses the mechanical precision of quasi-static force control and the sensitivity of eigenmode signals to variations in surface properties and enables simultaneous topographical, mechanical, and compositional mapping. We apply this technique to

Molecular and mechanical insights into gecko seta adhesion: multiscale simulations combining molecular dynamics and the finite element method

• Yash Jain,
• Saeed Norouzi,
• Tobias Materzok,
• Stanislav N. Gorb and
• Florian Müller-Plathe

Beilstein J. Nanotechnol. 2025, 16, 2055–2076, doi:10.3762/bjnano.16.141

• microscopy (AFM) experiments. Our investigation into how gecko keratin interacts with hydrophilic and hydrophobic substrates [12] supported the importance of the water-mediating effect [10] and elucidated mechanistic differences depending on surface chemistry. A particle-based mesoscale model of a single

• surface, and a 13 nm thick amorphous bulk below, which matched the same bead density as our previous random-substrate model. All substrate beads had identical interactions with the spatula, and both layers were held fixed in space. Since the regular top monolayer differed from the fully random arrangement

• used previously, we re-parameterized the spatula–substrate Lennard-Jones interactions: so that the new surface would have the same pull-off (adhesion) pressure as before. Specifically, several parameter combinations were tested in pull-off simulations against our reference data for gecko keratin [12

Stereodiscrimination of guests in chiral organosilica aerogels studied by ESR spectroscopy

• Sebastian Polarz,
• Yasar Krysiak,
• Martin Wessig and
• Florian Kuhlmann

Beilstein J. Nanotechnol. 2025, 16, 2034–2054, doi:10.3762/bjnano.16.140

• of a surface influences the stereoselectivity of the enantiomers at the surface. Despite the difference in the interaction enthalpies being only in the 1–2 kJ·mol−1 range, an ideal surface would exclusively interact with one enantiomer. However, the question of which selectivity is sufficient or

• available material confirmed the method’s reliability. The data underline how crucial the choice of the right solvent is if one wants to reach sufficient selectivity. Together with a series of custom-made organosilica aerogels, it is shown that adjusting solvent and surface properties so that the two

• enantiomers (+) and (−) experience a different chemical environment is key. Otherwise, there might be a dynamic equilibrium between surface-adsorbed and mobile spin probes without stereodifferentiation. With this knowledge, it was possible to reach higher selectivity values than for the commercial material. A

Beyond the shell: exploring polymer–lipid interfaces in core–shell nanofibers to carry hyaluronic acid and β-caryophyllene

• Aline Tavares da Silva Barreto,
• Francisco Alexandrino-Júnior,
• Bráulio Soares Arcanjo,
• Paulo Henrique de Souza Picciani and
• Kattya Gyselle de Holanda e Silva

Beilstein J. Nanotechnol. 2025, 16, 2015–2033, doi:10.3762/bjnano.16.139

• -sectional imaging, and attenuated total reflectance with Fourier transform infrared (ATR-FTIR) spectroscopy provided compelling evidence for the successful formation of the intended core–shell structure. The resulting nanofibers exhibited surface hydrophobicity, suggesting potential for anti-adhesive

• advancements in the controlled release of diverse bioactive compounds [5][6][7][8][9][10]. Among the various nanostructured platforms explored for these purposes, nanofibers have gained attention due to their high surface area, adjustable porosity, and robust mechanical properties, which set them apart from

• concentration, surface tension, conductivity, and solvent volatility, alongside careful consideration of electrospinning conditions, such as temperature and humidity [18][19]. The polymer selection of nanofibers intended for biomedical applications must prioritize not only mechanical strength, controlled

The cement of the tube-dwelling polychaete Sabellaria alveolata: a complex composite adhesive material

• Emilie Duthoo,
• Aurélie Lambert,
• Pierre Becker,
• Carla Pugliese,
• Jean-Marc Baele,
• Arnaud Delfairière,
• Matthew J. Harrington and
• Patrick Flammang

Beilstein J. Nanotechnol. 2025, 16, 1998–2014, doi:10.3762/bjnano.16.138

• (Figure 1F, Figure 3B,C). Its surface is covered with cilia, which are especially numerous at the tip of the lobes (Figure 3D). A pit-like opening that allows for the release of secretory granules is visible on the inner face of each lobe, slightly below its tip (Figure 3E,F). The two lobes of the

• small lacunae (Figure 7). The secretory granules from both types of cement cells are excreted simultaneously through individual pores on the epidermal surface of the building organ. There, the homogeneous material from the granules of the two types of cement cells appears to coalesce to form the matrix

Laser ablation in liquids for shape-tailored synthesis of nanomaterials: status and challenges

• Natalie Tarasenka

Beilstein J. Nanotechnol. 2025, 16, 1963–1997, doi:10.3762/bjnano.16.137

• . Despite many synthesis methods are still mainly focused on the production of near-spherical NPs, a number of emerging applications require nanomaterials of nonspherical shape and developed surface, which determine the functional performance of nanostructured devices. Laser ablation in liquids has been

• : thermal evaporation and explosive ejection [1]. According to the thermal evaporation mechanism, the action of a laser beam on the surface of a solid target initiates the absorption of the laser pulse energy. This results in initiation of melting and ionization with the formation of a plasma plume near the

• target surface. The current understanding of the mechanisms of PLAL distinguishes the process depending on the laser pulse duration (Figure 1a). For the ultrashort pulses (femtosecond duration) the interaction of the ejected material with the laser pulse can be neglected. For longer laser pulses

Mechanical property measurements enabled by short-term Fourier-transform of atomic force microscopy thermal deflection analysis

• Thomas Mathias,
• Roland Bennewitz and
• Philip Egberts

Beilstein J. Nanotechnol. 2025, 16, 1952–1962, doi:10.3762/bjnano.16.136

• Contact resonance atomic force microscopy (CR-AFM) has been used in many studies to characterize variations in the elastic and viscoelastic constants of materials along a heterogeneous surface. In almost all experimental work, the quantitative modulus of the surface is calculated in reference to a known

• dynamic mechanics models relating the contact stiffness of the tip/cantilever pressing into a surface with the oscillation frequency of the cantilever and show that they did not accurately model the experiment. Several material combinations of tip and sample were examined; tip size and cantilever

• ); mechanical property measurements; surface science; Introduction Atomic force microscopy (AFM) has become an indispensable tool for imaging the surface topography on a variety of surfaces [1]. Since the invention of the AFM [2], several other modes of AFM have been developed, including friction force

Evaluating metal-organic precursors for focused ion beam-induced deposition through solid-layer decomposition analysis

• Benedykt R. Jany,
• Katarzyna Madajska,
• Aleksandra Butrymowicz-Kubiak,
• Franciszek Krok and
• Iwona B. Szymańska

Beilstein J. Nanotechnol. 2025, 16, 1942–1951, doi:10.3762/bjnano.16.135

• duration of the electron or ion beam pulses. In FEBID and FIBID, volatile precursor molecules are delivered to the substrate surface via a gas injection system (GIS), where they adsorb and are subsequently decomposed by a focused electron or ion beam with energies in the kiloelectronvolt range. While

• masks, and resistance, with the flexibility of depositing materials on non-planar surfaces [4][5][14]. The FIBID method has several advantages compared to the FEBID technique in depositing thin films on substrates. First, ions generate more secondary electrons on the substrate surface than electrons

• adsorbed on the surface, such as electron-stimulated desorption, high-resolution electron energy loss spectroscopy, and focused electron beam secondary ion mass spectrometry [5]. To characterize compounds in terms of their applicability in the FIBID process, comparisons are made with the FEBID process, and

Quantum circuits with SINIS structures

• Mikhail Tarasov,
• Mikhail Fominskii,
• Aleksandra Gunbina,
• Artem Krasilnikov,
• Maria Mansfeld,
• Dmitrii Kukushkin,
• Andrei Maruhno,
• Valeria Ievleva,
• Mikhail Strelkov,
• Daniil Zhogov,
• Konstantin Arutyunov,
• Vyacheslav Vdovin,
• Vladislav Stolyarov and
• Valerian Edelman

Beilstein J. Nanotechnol. 2025, 16, 1931–1941, doi:10.3762/bjnano.16.134

• ) bolometers [16][17], and SINIS detectors [18][19][20]. Here, we present an overview and comparison of our SINIS devices manufactured using different methods. The advantage of Al-based technology is the presence of the intrinsic oxide on its surface, which prevents short circuits with subsequent conductive

• tunnel junction In tunnel structures, the barrier is a dielectric layer between two metal films (often the oxide layer on the surface of the first metal layer is used as a dielectric). The first experimental study of a tunnel junction was carried out in 1960 [21] for an aluminum–aluminum oxide–lead

PEGylated lipids in lipid nanoparticle delivery dynamics and therapeutic innovation

• Peiyang Gao

Beilstein J. Nanotechnol. 2025, 16, 1914–1930, doi:10.3762/bjnano.16.133

• chains arrange on the nanoparticle surface and the potential impacts on LNPs’ physicochemical properties by varying surface PEG density or PEG chemistry. Subsequently, PEG conformations are discussed in terms of their modulation of protein corona formation, cellular uptake, and immunogenic responses

• review first reveals the localization and conformation of PEG lipids on the LNP surface, which is fundamental for understanding how PEG lipids contribute to nanoparticle stability and surface interactions. It then demonstrates how PEG density and chemical structure may influence the physicochemical

• properties of LNPs including particle size, surface charge, and encapsulation efficiency. Subsequent sections explore the roles of PEG lipids in modulating protein corona formation and cellular uptake. The latter parts highlight the potential of functionalized PEG lipids for targeted delivery and the

Low-temperature AFM with a microwave cavity optomechanical transducer

• Ermes Scarano,
• Elisabet K. Arvidsson,
• August K. Roos,
• Erik Holmgren,
• Riccardo Borgani,
• Mats O. Tholén and
• David B. Haviland

Beilstein J. Nanotechnol. 2025, 16, 1873–1882, doi:10.3762/bjnano.16.130

• force-sensor design is a significant improvement over piezoelectric force sensors commonly used in low-temperature AFM. We discuss the potential for further improvement of the sensor design to achieve optimal detection at the standard quantum limit. We demonstrate AFM operation with surface-tracking

• ]. The challenge for high-resolution AFM is designing such a detector for a test mass hosting a sharp tip that is scanned over a surface in ultrahigh vacuum and at ultralow temperature. In this paper, we report on an AFM cantilever force sensor with an integrated detector consisting of a compact

• electromechanical coupling (KIMEC), whose design and fabrication were already presented in detail in previous publications by our group [17][18]. Here, we focus on the deployment of the force sensor, demonstrating force-gradient sensing and scanning over a test surface at 10 mK in a closed-cycle dilution

Self-assembly and adhesive properties of Pollicipes pollicipes barnacle cement protein cp19k: influence of pH and ionic strength

• Shrutika Sawant,
• Anne Marie Power and
• J. Gerard Wall

Beilstein J. Nanotechnol. 2025, 16, 1863–1872, doi:10.3762/bjnano.16.129

• Sciences, University of Galway H91 TK33, Ireland 10.3762/bjnano.16.129 Abstract Marine organisms such as barnacles rely on a complex underwater adhesive system, driven by self-assembly and intermolecular associations between cement proteins, for permanent attachment to a variety of surface types. In this

• bioinspired adhesives and biomaterials. Keywords: adhesive; amyloid fibre; barnacle cement protein; surface coating; transmission electron microscopy; Introduction Marine adhesives are naturally occurring substances secreted by a variety of organisms to attach themselves to submerged surfaces such as rocks

• secreted by the foot [4]. Each thread ends in an adhesive plaque composed of mussel foot proteins (Mfps), which are rich in the modified amino acid ʟ-3,4-dihydroxyphenylalanine (DOPA) [5]. DOPA is formed via post-translational hydroxylation of tyrosine and mediates wet surface adhesion through hydrogen

On the road to sustainability – application of metallic nanoparticles obtained by green synthesis in dentistry: a scoping review

• Lorena Pinheiro Vasconcelos Silva,
• Joice Catiane Soares Martins,
• Israel Luís Carvalho Diniz,
• Júlio Abreu Miranda,
• Danilo Rodrigues de Souza,
• Éverton do Nascimento Alencar,
• Moan Jéfter Fernandes Costa and
• Pedro Henrique Sette-de-Souza

Beilstein J. Nanotechnol. 2025, 16, 1851–1862, doi:10.3762/bjnano.16.128

• widely studied nanomaterials are metallic nanoparticles, particularly silver (AgNPs), gold (AuNPs), and copper (CuNPs), and various metal oxide nanoparticles such as zinc oxide (ZnO-NPs), due to their high surface-to-volume ratio, chemical stability, and distinctive optical and antimicrobial properties

• nanoparticle formation in real time by detecting surface plasmon resonance bands, which provide insight into particle size and distribution [57]. XRD offers detailed information on the crystalline structure and phase composition of the nanoparticles, confirming successful synthesis and purity [53]. Together

Current status of using adsorbent nanomaterials for removing microplastics from water supply systems: a mini review

• Nguyen Thi Nhan and
• Tran Le Luu

Beilstein J. Nanotechnol. 2025, 16, 1837–1850, doi:10.3762/bjnano.16.127

• conventional treatments removing only 40–70%, especially struggling with smaller particles. Based mainly on mechanisms like electrostatic interactions, hydrophobic interactions, pore filling, hydrogen bonding, π–π stacking, and surface complexation, adsorbent nanomaterials achieve over 90% removal of MPs and

• (MPs) related to public health and environmental risks have gained significant attention [1]. Because of their small size, high surface area, and hydrophobic properties, MPs can act as vectors for toxic chemicals, including heavy metals (lead, cadmium, or mercury) and persistent organic pollutants like

• fragments, 11–12 μg·m−1) compared to two-year-old (720–247 μg·m−1) and ten-year-old ropes (767–1052 μg·m−1) [34]. Thus, natural water sources such as surface water (rivers, lakes, and streams) and groundwater have received large amounts of MPs from various sources. These water sources play an important role

Phytol-loaded soybean oil nanoemulsion as a promising alternative against Leishmania amazonensis

• Victória Louise Pinto Freire,
• Mariana Farias Alves-Silva,
• Johny W. de Freitas Oliveira,
• Matheus de Freitas Fernandes-Pedrosa,
• Alianda Maira Cornélio,
• Marcelo de Souza-Silva,
• Thayse Silva Medeiros and
• Arnóbio Antônio da Silva Junior

Beilstein J. Nanotechnol. 2025, 16, 1826–1836, doi:10.3762/bjnano.16.126

• thermal degradation of sensitive compounds, as well as excessive loss of volatile substances such as PHYT [30]. The small droplet size results in a large surface area, which enables effective interaction with biological membranes and consequently enhances drug penetration and retention [31]. Key

• surface curvature and increased solute concentration at the droplet interface in the aqueous phase. Such structural features can promote a higher drug flux and localized delivery in the skin layers [34][35][36]. Chiu et al. (2024) reported a significant increase in curcumin skin permeability when carried

Electrical, photocatalytic, and sensory properties of graphene oxide and polyimide implanted with low- and medium-energy silver ions

• Josef Novák,
• Eva Štěpanovská,
• Petr Malinský,
• Vlastimil Mazánek,
• Jan Luxa,
• Ulrich Kentsch and
• Zdeněk Sofer

Beilstein J. Nanotechnol. 2025, 16, 1794–1811, doi:10.3762/bjnano.16.123

• implantation provides a controllable alternative for tuning surface properties at the nanoscale, enabling the targeted introduction of functional species without chemical reagents. This work investigates the effects of low-energy (20 keV) and medium-energy (1.5 MeV) Ag+ ion implantation on the electrical

• of GO and PI. Elemental and structural changes induced by implantation were analyzed using Rutherford backscattering spectroscopy, elastic recoil detection analysis, Raman spectroscopy, Fourier-transform infrared spectroscopy, and X-ray photoelectron spectroscopy. Surface morphology was assessed via

• atomic force microscopy. Electrical properties as a function of air humidity were evaluated using a two-point method, and photocatalytic activity was tested by monitoring the UV-induced decomposition of rhodamine B. The results demonstrate that ion implantation significantly reduces surface resistivity

Exploring the potential of polymers: advancements in oral nanocarrier technology

• Rousilândia de Araujo Silva,
• Igor Eduardo Silva Arruda,
• Luise Lopes Chaves,
• Mônica Felts de La Roca Soares and
• Jose Lamartine Soares Sobrinho

Beilstein J. Nanotechnol. 2025, 16, 1751–1793, doi:10.3762/bjnano.16.122

• through the epithelium occurs via the transcellular and paracellular pathways, as well as through M cells located on the surface of Peyer’s patches [8]. Positioned under the mucus layer, the intestinal epithelium plays crucial roles in defending against hostile contents, selectively absorbing nutrients

• therapeutic payload and intestinal permeability [17]. PNs represent a viable strategy for overcoming GIT barriers in oral drug delivery. The polymeric composition allows for diverse and sophisticated designs, with primary advantages including the ability to control size, shape, and surface charge. Furthermore

• , thereby achieving highly efficient drug release [18]. This interaction with biological systems without inducing negative or toxic effects is attributed to their biocompatibility and biodegradability [19]. Surface design plays a pivotal role in PNs for oral use, as it dictates their behavior during

Advances of aptamers in esophageal cancer diagnosis, treatment and drug delivery

• Yang Fei,
• Hui Xu,
• Chunwei Zhang,
• Jingjing Wang and
• Yong Jin

Beilstein J. Nanotechnol. 2025, 16, 1734–1750, doi:10.3762/bjnano.16.121

• -delivery of a P-glycoprotein (P-gp) inhibitor, specifically, small interfering RNA (siRNA) against the MDR1 gene, along with the chemotherapeutic agent doxorubicin (DOX). This system capitalizes on the high-affinity binding of the AS1411 aptamer to nucleolin, a protein overexpressed on the surface of

• optimal biocompatibility, structural stability, and superior drug-loading capacity. However, nanocarriers are prone to complement system recognition [39] and clearance due to their microbial-scale dimensions and surface-exposed nucleophilic groups, which inadvertently trigger immune activation and

• contribute to off-target effects. This fundamental limitation explains the persistent observation of diverse adverse effects in both preclinical animal studies and clinical applications of carrier-modified therapeutics. If aptamer modification is carried out on the surface of the carrier [40], it will help