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Search for "targeting" in Full Text gives 146 result(s) in Beilstein Journal of Nanotechnology.
Non-covalent and reversible functionalization of carbon nanotubes
Beilstein J. Nanotechnol. 2014, 5, 1675–1690, doi:10.3762/bjnano.5.178
- ) do precipitate on addition of further polymer. The adsorption–desorption equilibrium is a real critical point when dealing with dilution steps (i.e., administration of drug targeting SWCNTs in the blood stream) as it is important to ascertain that a proper amount of the dispersant keeps covering the
Precise quantification of silica and ceria nanoparticle uptake revealed by 3D fluorescence microscopy
Beilstein J. Nanotechnol. 2014, 5, 1616–1624, doi:10.3762/bjnano.5.173
- values. For example, Particle_in_Cell-3D was used to compare the uptake efficiency of therapeutic nanoparticles for gene delivery functionalized with different targeting ligands [30]. In addition, our method was successfully applied to measure the influence of flow conditions on the cellular uptake of
In vitro interaction of colloidal nanoparticles with mammalian cells: What have we learned thus far?
Beilstein J. Nanotechnol. 2014, 5, 1477–1490, doi:10.3762/bjnano.5.161
- fact that specific targeting still is possible [84], enough ligands still are biologically active. For highly defined NPs, such as nearly monodisperse NPs overcoated with a shell of an amphiphilic polymer [135], the corona formed by special model proteins can be surprisingly well organized. By using
A sonochemical approach to the direct surface functionalization of superparamagnetic iron oxide nanoparticles with (3-aminopropyl)triethoxysilane
Beilstein J. Nanotechnol. 2014, 5, 1472–1476, doi:10.3762/bjnano.5.160
- used as linker in the synthesis of composite or hybrid nanoparticles consisting of SPION and other inorganic materials such as gold nanoparticles [5][6]. More importantly, for targeting and delivery purposes the functional amine moiety can further be modified with other functional groups, such as
The cell-type specific uptake of polymer-coated or micelle-embedded QDs and SPIOs does not provoke an acute pro-inflammatory response in the liver
Beilstein J. Nanotechnol. 2014, 5, 1432–1440, doi:10.3762/bjnano.5.155
- endothelial cells. In contrast, nanocrystals transported by lipid micelles are detected within hepatic macrophages, the Kupffer cells, and within liver parenchymal cells, the hepatocytes. Intriguingly, even 48 h after injection, neither changing the embedding procedure nor the cellular targeting provoked any
- lipid moieties of lipid micelles as well as PMAOD of the polymer coat most likely determine the cell type-specific uptake of nanocrystals. In order to investigate subcellular targeting of internalized nanocrystals, we performed cryo-electron microscopy after the injection of either SPIOs–lipid micelles
- (Figure 2A–C) or polymer-coated SPIOs (Figure 2D,E). These studies confirmed Kupffer cell targeting of nanocrystals transported by lipid micelles (Figure 2A). Higher magnification revealed the subcellular transport and storage of numerous SPIOs within lipid droplet-like structures (Figure 2B,C) suggesting
The protein corona protects against size- and dose-dependent toxicity of amorphous silica nanoparticles
Beilstein J. Nanotechnol. 2014, 5, 1380–1392, doi:10.3762/bjnano.5.151
- modulate nanoparticle-induced processes such as opsonization which have direct consequences on the mode of interaction with cells, the efficacy of cellular NP uptake and thus, the organ targeting, biodistribution, and circulatio time of NP in vertebrates and non-vertebrates [22]. Our study indicates that
PEGylated versus non-PEGylated magnetic nanoparticles as camptothecin delivery system
Beilstein J. Nanotechnol. 2014, 5, 1312–1319, doi:10.3762/bjnano.5.144
- covalent attachment of targeting cargoes such as antibodies. Molecular structure of (S)-(+)-camptothecin (1) and its inactive form (2) through lactone ring hydrolysis at physiological pH. Bright field (a) and dark field (b) transmission electron microscopy (TEM) images and diffraction pattern (c) of USM
Model systems for studying cell adhesion and biomimetic actin networks
Beilstein J. Nanotechnol. 2014, 5, 1193–1202, doi:10.3762/bjnano.5.131
- cytoskeletal assembly and membrane targeting. Further research on the influence of talin on lipid membranes was carried out by Takiguchi and co-workers, who studied the effects of adding talin to liposome solutions. They discovered a membrane-breaking function of talin: Lipid membranes were found to open
Nanodiamond-DGEA peptide conjugates for enhanced delivery of doxorubicin to prostate cancer
Beilstein J. Nanotechnol. 2014, 5, 937–945, doi:10.3762/bjnano.5.107
- targeted drug delivery systems can provide an avenue to overcome these issues. Nanodiamonds (ND), in particular, have been researched over the past five years for use in various drug delivery systems but minimal work has been done that incorporates targeting capability. In this study, a novel targeted drug
- cardiomyopathy (weakening of the heart muscle) [4][5]. Like most clinical chemotherapy regimens, DOX lacks specificity (or targeting) and eradicates most rapidly dividing cells (e.g., hair, immune, and many other types of normal cells). As a result, there is a need to improve treatment specificity, efficacy, and
- toxicity by incorporating mechanisms for targeted delivery of chemotherapeutics. Nanomedicine has become a viable solution for the specificity and toxicity problems with current chemotherapy treatment regimens [6][7][8][9]. Nanoparticles have facilitated tumor targeting and drug delivery in a variety of
Integration of ZnO and CuO nanowires into a thermoelectric module
Beilstein J. Nanotechnol. 2014, 5, 927–936, doi:10.3762/bjnano.5.106
- present the fabrication by simple and low-cost physical methods of both n- and p-metal oxide nanowires in order to build a prototype of planar thermoelectric unit based on metal oxide nanowire arrays, targeting different applications ranging from radioisotope thermoelectric generators [14][15][16] to
Optimizing the synthesis of CdS/ZnS core/shell semiconductor nanocrystals for bioimaging applications
Beilstein J. Nanotechnol. 2014, 5, 919–926, doi:10.3762/bjnano.5.105
- optical probes for various immunoassays, multiplex imaging of cancer cells, and in vivo cancer targeting and imaging studies, etc. In 1998, Nie and Alivisatos were the first to report on the potential applications of QDs in biology [8][9]. There is no doubt that QDs offer a new tool for the multiplexed
Scale effects of nanomechanical properties and deformation behavior of Au nanoparticle and thin film using depth sensing nanoindentation
Beilstein J. Nanotechnol. 2014, 5, 822–836, doi:10.3762/bjnano.5.94
- tribological applications on the macro- to nanoscale and applications requiring controlled manipulation and targeting [25]. In these environments the nanoparticles can be deformed locally or the entire nanoparticle can be compressed. Knowledge of the mechanical properties and deformation mechanisms involved
In vitro toxicity and bioimaging studies of gold nanorods formulations coated with biofunctional thiol-PEG molecules and Pluronic block copolymers
Beilstein J. Nanotechnol. 2014, 5, 546–553, doi:10.3762/bjnano.5.64
- studies [20][21][22][23]. It is noteworthy that these PEG polymers can even be modified with additional functional groups such as a carboxyl and an amino group for the conjugation of targeting ligands. It is known that the CTAB bilayers on a AuNRs surface can be removed and replaced with PEG-SH molecules
In situ growth optimization in focused electron-beam induced deposition
Beilstein J. Nanotechnol. 2013, 4, 919–926, doi:10.3762/bjnano.4.103
- conductivity. By using the gradient of the measured in situ rate of change of conductance as a fitness parameter the GA was able to tune the metal content of tungsten deposits created from W(CO)6 over a large range by either targeting the highest or lowest conductance, respectively. This resulted in a
High-resolution electrical and chemical characterization of nm-scale organic and inorganic devices
Beilstein J. Nanotechnol. 2013, 4, 318–319, doi:10.3762/bjnano.4.35
- increase in “More than Moore” developments targeting energy (photovoltaic, energy storage), imaging (e.g., quantitative medical imaging), sensor/actuators linked to CMOS-base circuitry, biochips, etc. The utilization of graphene in order to process high mobility (both for holes and electrons) field-effect
- present the work of various leading labs in developing such techniques. Targeting 2-D/3-D resolution, one inevitably needs to look at scanning probe techniques that can be proclaimed to be dominant for electrical characterization and atomic probes that can be viewed as the ultimate in terms of
Diamond nanophotonics
Beilstein J. Nanotechnol. 2012, 3, 895–908, doi:10.3762/bjnano.3.100
- hemisphere and subsequently through the curved surface. The saturation curves are well described with a rate model for a two-level system. With this macroscopic diamond hemisphere, fluorescence count rates up to about 420 kHz are observed, which is sufficient for a number of important applications targeting
Effect of spherical Au nanoparticles on nanofriction and wear reduction in dry and liquid environments
Beilstein J. Nanotechnol. 2012, 3, 759–772, doi:10.3762/bjnano.3.85
- applications in liquids requiring controlled manipulation and targeting. On the macroscale, nanoparticles in solids and liquids have been shown to reduce friction and wear. On the nanoscale, atomic force microscopy (AFM) studies have been performed in single- and multiple-nanoparticle contact, in dry
- ; nanomanipulation; Introduction Nano-objects are continually studied in tribological applications and increasingly in other applications that require controlled manipulation and targeting in liquid environments. The need for suitable forms of lubrication for micro/nanoelectromechanical systems (MEMS/NEMS) and the
- needed become high, which can hinder device operation and reliability [2]. The choice of a suitable lubricant on these scales becomes crucial. Nano-objects are also used for applications that require controlled manipulation and targeting mechanisms in biomedicine and the oil industry. Applications
Nanolesions induced by heavy ions in human tissues: Experimental and theoretical studies
Beilstein J. Nanotechnol. 2012, 3, 556–563, doi:10.3762/bjnano.3.64
- after single-ion irradiation. The left-hand image shows the aimed targeting of chromo centers (red crosses) for single-ion irradiation by using Hoechst 33342 (grey scale) as a marker in the nuclei of living MEF cells. The right-hand image shows the same nucleus after fixation at 5 min after irradiation
Improvement of the oxidation stability of cobalt nanoparticles
Beilstein J. Nanotechnol. 2012, 3, 75–81, doi:10.3762/bjnano.3.9
- to their application potential in data storage [1] and in sensor applications [2], as well as for biomedical uses in therapy and diagnosis. By opening novel mechanisms for drug targeting [3], controlled drug release, hyperthermia [4][5] and imaging applications [6][7] there is a need for well
Magnetic nanoparticles for biomedical NMR-based diagnostics
Beilstein J. Nanotechnol. 2010, 1, 142–154, doi:10.3762/bjnano.1.17
- ). Bioorthogonal nanoparticle detection In addition to the previous strategies to improve the MNP core to enhance their relaxivities, surface modification of nanoparticles also improves their biosensing capabilities by amplifying their targeting valency for DMR applications. Bioorthogonal “click” chemistry has
- chemistry has been successfully adapted to magnetic targeting, so as to improve nanoparticle binding efficiency and detection sensitivity. Termed ‘bioorthogonal nanoparticle detection’ (BOND), this technique provides a novel targeting platform in which Tz and TCO act as the coupling agents [53]. In a two
- -applicable and scalable for biomedical use. BOND-2 has already been successfully adapted for molecular profiling of cell samples by DMR [53], and has now established itself as a major targeting method in our laboratory. Table 1 lists a library of cellular makers tested with BOND-2 and DMR. Miniaturized NMR
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