Better together: biomimetic nanomedicines for high performance tumor therapy

• Imran Shair Mohammad,
• Gizem Kursunluoglu,
• Anup Kumar Patel,
• Hafiz Muhammad Ishaq,
• Cansu Umran Tunc,
• Dilek Kanarya,
• Mubashar Rehman,
• Omer Aydin and
• Yin Lifang

Beilstein J. Nanotechnol. 2025, 16, 1246–1276, doi:10.3762/bjnano.16.92

• chemotherapeutic effects and synergistically kill the tumor cells [137]. The immunosuppressive TME considerably attenuated the chemotherapeutic effect of various anticancer drugs. Therefore, reprogramming of TME and targeting tumor-associated macrophages (TAMs) could be a promising strategy to enhance

Dual-functionalized architecture enables stable and tumor cell-specific SiO₂NPs in complex biological fluids

• Iris Renata Sousa Ribeiro,
• Raquel Frenedoso da Silva,
• Romênia Ramos Domingues,
• Adriana Franco Paes Leme and
• Mateus Borba Cardoso

Beilstein J. Nanotechnol. 2024, 15, 1238–1252, doi:10.3762/bjnano.15.100

• exhibit heightened efficacy and reduced toxicity for medical purposes. Keywords: colloidal stability; complex media; functionalized nanoparticles; hemolysis; targeting tumor; Introduction In recent years, there has been a growing search for developing high-efficiency nanomedicines for cancer treatment

Recent progress in cancer cell membrane-based nanoparticles for biomedical applications

• Qixiong Lin,
• Yueyou Peng,
• Yanyan Wen,
• Xiaoqiong Li,
• Donglian Du,
• Weibin Dai,
• Wei Tian and
• Yanfeng Meng

Beilstein J. Nanotechnol. 2023, 14, 262–279, doi:10.3762/bjnano.14.24

• insufficient targeting. The 4T1 cell membrane-coated NPs exert multiple antitumor functions after entering the blood circulation and targeting tumor tissues [23]. This targeted strategy, which does not depend on ER, RR, or HER2, shows good prospects for the treatment of metastatic TNBC. 3.2 Hematological

• biomimetic NPs consists of poly(citrate–peptide) (PCP) and miRNA365 mimic as the core and are coated with the MC38 cell membrane. After targeting tumor tissue, the NPs exert antitumor effects by inhibiting the expression of Ki67/Bcl2 and enhancing tumor cell apoptosis [55]. This strategy combining gene

Rational design of block copolymer self-assemblies in photodynamic therapy

• Maxime Demazeau,
• Laure Gibot,
• Anne-Françoise Mingotaud,
• Patricia Vicendo,
• Clément Roux and
• Barbara Lonetti

Beilstein J. Nanotechnol. 2020, 11, 180–212, doi:10.3762/bjnano.11.15

• enable entities smaller than these gaps to leave the bloodstream. Secondly, defects of the lymphatic system in tumors prevent these macromolecular therapeutics to be cleared from the tumor, giving them additional time to release their active cargo. This was the first example of targeting tumor tissues

Scavenging of reactive oxygen species by phenolic compound-modified maghemite nanoparticles

• Małgorzata Świętek,
• Yi-Chin Lu,
• Rafał Konefał,
• Liliana P. Ferreira,
• M. Margarida Cruz,
• Yunn-Hwa Ma and
• Daniel Horák

Beilstein J. Nanotechnol. 2019, 10, 1073–1088, doi:10.3762/bjnano.10.108

• , targeting tumor sites using an external magnetic field, MRI contrast agents, or magnetic hyperthermia. Under physiological conditions, the nanoparticle surface is exposed to the action of biomolecules, oxygen, peroxides, and radicals, which changes particle properties and behavior. Moreover, Fe2+ ions can