Nanocarriers and macrophage interaction: from a potential hurdle to an alternative therapeutic strategy

• Naths Grazia Sukubo,
• Paolo Bigini and
• Annalisa Morelli

Beilstein J. Nanotechnol. 2025, 16, 97–118, doi:10.3762/bjnano.16.10

• target CD44 receptors on macrophages, improving drug delivery in inflammatory disease models and highlighting their potential in treating chronic inflammation and autoimmune conditions [58]. Beyond surface modifications, innovative strategies have used macrophages as “Trojan horse”-like carriers for drug

Theoretical study of the electronic and optical properties of a composite formed by the zeolite NaA and a magnetite cluster

• Joel Antúnez-García,
• Roberto Núñez-González,
• Vitalii Petranovskii,
• H’Linh Hmok,
• Armando Reyes-Serrato,
• Fabian N. Murrieta-Rico,
• Mufei Xiao and
• Jonathan Zamora

Beilstein J. Nanotechnol. 2025, 16, 44–53, doi:10.3762/bjnano.16.5

• composite under investigation (labeled as NaA-M) and served as the basis from which we computed its optical and electronic properties in this study. The electronic and optical properties of zeolite NaA, the magnetite cluster, and the NaA-M composite were computed using the Wien2k computer code [58]. This

Fabrication of hafnium-based nanoparticles and nanostructures using picosecond laser ablation

• Abhishek Das,
• Mangababu Akkanaboina,
• Jagannath Rathod,
• R. Sai Prasad Goud,
• Kanaka Ravi Kumar,
• Raghu C. Reddy,
• Ratheesh Ravendran,
• Katia Vutova,
• S. V. S. Nageswara Rao and
• Venugopal Rao Soma

Beilstein J. Nanotechnol. 2024, 15, 1639–1653, doi:10.3762/bjnano.15.129

• the depressions of the LSFL with a direction perpendicular to the direction of the laser scan. Similar observations regarding the formation of LSFL and HSFL with orthogonal directionality and the plausible mechanisms behind their formation are discussed in an earlier work [58]. Figure 11 shows FESEM

Biomimetic nanocarriers: integrating natural functions for advanced therapeutic applications

• Hugo Felix Perini,
• Beatriz Sodré Matos,
• Carlo José Freire de Oliveira and
• Marcos Vinicius da Silva

Beilstein J. Nanotechnol. 2024, 15, 1619–1626, doi:10.3762/bjnano.15.127

• membrane constructs [58]. Regarding materials for coating nanoparticles, a variety of hydrophilic polymers are available [30]. The most prevalent technique involves the use of polyethylene glycol (PEG). It provides biological protection against proteolysis and improved biocompatibility, metabolism, and

Natural nanofibers embedded in the seed mucilage envelope: composite hydrogels with specific adhesive and frictional properties

• Agnieszka Kreitschitz and
• Stanislav N. Gorb

Beilstein J. Nanotechnol. 2024, 15, 1603–1618, doi:10.3762/bjnano.15.126

• wall architecture has been studied in many cases on the primary cell wall of parenchymatous, root tip, or epidermal cells [54][57][58][59]. Visualisation of the secondary cell wall was previously carried out for tracheary elements of xylem [60][61][62]. The microfibrils of the primary cell wall are

Liver-targeting iron oxide nanoparticles and their complexes with plant extracts for biocompatibility

• Shushanik A. Kazaryan,
• Seda A. Oganian,
• Gayane S. Vardanyan,
• Anatolie S. Sidorenko and
• Ashkhen A. Hovhannisyan

Beilstein J. Nanotechnol. 2024, 15, 1593–1602, doi:10.3762/bjnano.15.125

• Fe3O4 NPs (20–30 nm) administered to rat livers at doses up to 75 µg/g did not result in statistically significant changes in ALT, AST, and ALP activities [58]. Among the most important processes occurring in the liver are lipid metabolism and lipoprotein synthesis, which characterize its functional

Green synthesis of silver nanoparticles derived from algae and their larvicidal properties to control Aedes aegypti

• Matheus Alves Siqueira de Assunção,
• Douglas Dourado,
• Daiane Rodrigues dos Santos,
• Gabriel Bezerra Faierstein,
• Mara Elga Medeiros Braga,
• Severino Alves Junior,
• Rosângela Maria Rodrigues Barbosa,
• Herminio José Cipriano de Sousa and
• Fábio Rocha Formiga

Beilstein J. Nanotechnol. 2024, 15, 1566–1575, doi:10.3762/bjnano.15.123

• . These compounds act by reducing Ag+ ions to Ag0 and stabilize nanoparticles by capping [58] (Figure 2). Larvicidal activity of AgNPs against Aedes aegypti Aedes aegypti, also known as the dengue mosquito, is a vector of important arboviruses, including Dengue, Zika, Chikungunya and Yellow Fever [6][59

The round-robin approach applied to nanoinformatics: consensus prediction of nanomaterials zeta potential

• Dimitra-Danai Varsou,
• Arkaprava Banerjee,
• Joyita Roy,
• Kunal Roy,
• Giannis Savvas,
• Haralambos Sarimveis,
• Ewelina Wyrzykowska,
• Mateusz Balicki,
• Tomasz Puzyn,
• Georgia Melagraki,
• Iseult Lynch and
• Antreas Afantitis

Beilstein J. Nanotechnol. 2024, 15, 1536–1553, doi:10.3762/bjnano.15.121

• proposed by Golbraikh and Tropsha [57][58] (Equations 7–11, including , Equation 6) on the test set. According to Golbraikh and Tropsha [57][59][60] a regression model is considered predictive if all of the conditions presented in Table 2 are satisfied. where N is the number of samples, yi and are the

Integrating high-performance computing, machine learning, data management workflows, and infrastructures for multiscale simulations and nanomaterials technologies

• Fabio Le Piane,
• Mario Vozza,
• Matteo Baldoni and
• Francesco Mercuri

Beilstein J. Nanotechnol. 2024, 15, 1498–1521, doi:10.3762/bjnano.15.119

• fully digital data-centric approach Integration technologies try to tackle the issues outlined above by exploiting the efficiency of digital and data-centric approaches within a specific domain [48][58][59]. In this respect, integration merges tools and technologies within a customized framework and

Polymer lipid hybrid nanoparticles for phytochemical delivery: challenges, progress, and future prospects

• Iqra Rahat,
• Pooja Yadav,
• Aditi Singhal,
• Mohammad Fareed,
• Jaganathan Raja Purushothaman,
• Mohammed Aslam,
• Raju Balaji,
• Sonali Patil-Shinde and
• Md. Rizwanullah

Beilstein J. Nanotechnol. 2024, 15, 1473–1497, doi:10.3762/bjnano.15.118

• hybrid nanocarriers, the biological barriers in therapeutic drug delivery can be easily overcome. These hybrid nanocarriers show prolonged half-life and stability in biological systems, thereby enhancing therapeutic efficacy [58][59]. Surface modification of PLHNPs Surface modification of PLHNPs involves

Effect of radiation-induced vacancy saturation on the first-order phase transformation in nanoparticles: insights from a model

• Aram Shirinyan and
• Yuriy Bilogorodskyy

Beilstein J. Nanotechnol. 2024, 15, 1453–1472, doi:10.3762/bjnano.15.117

Ion-induced surface reactions and deposition from Pt(CO)₂Cl₂ and Pt(CO)₂Br₂

• Mohammed K. Abdel-Rahman,
• Patrick M. Eckhert,
• Atul Chaudhary,
• Johnathon M. Johnson,
• Jo-Chi Yu,
• Lisa McElwee-White and
• D. Howard Fairbrother

Beilstein J. Nanotechnol. 2024, 15, 1427–1439, doi:10.3762/bjnano.15.115

• deposits from Pt(CO)2Cl2 and Pt(CO)2Br2 resulted in deposits with Pt purities comparable to deposits made from MeCpPtMe3 [55][58]. Although the Pt content was similar, the deposits made from Pt(CO)2X2 suffered from a slower growth rate than those from MeCpPtMe3; this difference is attributed to the lower

• regions, Figure 5 presents the atomic concentration of CO, Cl, Br, and Pt in Pt(CO)2Cl2 and Pt(CO)2Br2 films during ion irradiation. The initial concentration was normalized to the precursors’ (C+O)/X/Pt atomic stoichiometry of 4:2:1, which corresponds to 58 atom % CO, 28 atom % X (Cl or Br), and 14 atom

• deposits formed under UHV conditions contained 58% Cl and 37% Pt with no detectable C or O signatures in EDX [55][57]. The AES and XPS data shown in Figure 6 as well as Figure S4 and Figure S5 (Supporting Information File 1) support the conclusions of the UHV studies, specifically that Pt(CO)2X2 can be

Lithium niobate on insulator: an emerging nanophotonic crystal for optimized light control

• Midhun Murali,
• Amit Banerjee and
• Tanmoy Basu

Beilstein J. Nanotechnol. 2024, 15, 1415–1426, doi:10.3762/bjnano.15.114

• effects, such as second-harmonic generation and four-wave mixing, are highly sensitive to the intensity of the electromagnetic field [1][57][58]. Moreover, mode confinement within the high-index regions of 1D photonic crystals plays a crucial role in the development of all-optical switches. These devices

Nanotechnological approaches for efficient N2B delivery: from small-molecule drugs to biopharmaceuticals

• Selin Akpinar Adscheid,
• Akif E. Türeli,
• Nazende Günday-Türeli and
• Marc Schneider

Beilstein J. Nanotechnol. 2024, 15, 1400–1414, doi:10.3762/bjnano.15.113

• by Li et al. showed that the trigeminal pathway could be the dominant pathway for the N2B delivery of intact polymeric NPs [57]. Furthermore, because of the highly vascularized nature of the respiratory region of the nose, drug transport can also follow a systemic pathway through this region [58

Various CVD-grown ZnO nanostructures for nanodevices and interdisciplinary applications

• The-Long Phan,
• Le Viet Cuong,
• Vu Dinh Lam and
• Ngoc Toan Dang

Beilstein J. Nanotechnol. 2024, 15, 1390–1399, doi:10.3762/bjnano.15.112

• sensitive in gas-sensing applications [58][59], and can be used to tune second harmonic polaritons coupling with nanocavity modes and generating polariton cavity modes [60]. The aforementioned results indicate the variety of ZnO nanostructures as well as complex physical mechanisms occurring during their

Hymenoptera and biomimetic surfaces: insights and innovations

• Vinicius Marques Lopez,
• Carlo Polidori and
• Rhainer Guillermo Ferreira

Beilstein J. Nanotechnol. 2024, 15, 1333–1352, doi:10.3762/bjnano.15.107

• of Hymenoptera, mandibles are known to include trace metals, mainly Zn and secondarily Mn, in the cuticle [57]; these features increase their hardness [58] (Figure 3A). Ants are by far the hymenopteran group where this trait was most extensively studied (21 species in total spanning five subfamilies

Nanoarchitectonics with cetrimonium bromide on metal nanoparticles for linker-free detection of toxic metal ions and catalytic degradation of 4-nitrophenol

• Akash Kumar and
• Raja Gopal Rayavarapu

Beilstein J. Nanotechnol. 2024, 15, 1312–1332, doi:10.3762/bjnano.15.106

Interaction of graphene oxide with tannic acid: computational modeling and toxicity mitigation in C. elegans

• Romana Petry,
• James M. de Almeida,
• Francine Côa,
• Felipe Crasto de Lima,
• Diego Stéfani T. Martinez and
• Adalberto Fazzio

Beilstein J. Nanotechnol. 2024, 15, 1297–1311, doi:10.3762/bjnano.15.105

• translocation to other organs or oxidative stress. Similarly, Rive et al. [58] did not detect any detrimental effects in C. elegans exposed to amino-functionalized GO. Moreover, biomolecules interacting with the GO surface also have an effect on its toxicity, Côa et al. [14] observed that a bovine serum albumin

Realizing active targeting in cancer nanomedicine with ultrasmall nanoparticles

• André F. Lima,
• Giselle Z. Justo and
• Alioscka A. Sousa

Beilstein J. Nanotechnol. 2024, 15, 1208–1226, doi:10.3762/bjnano.15.98

• proteins (Figure 2A) [52][53][54][55][56][57][58]. This occurs because of the small size and high surface curvature of usNPs, which restrict the binding interface for proteins. As a result, protein spreading and denaturation on the usNP surface are minimized, and fewer non-covalent interactions form

• functionalized to bind to target receptors without interference from nonspecific protein interactions. Figure 2A, 2C, and 2D were adapted from [58]. (“Biomolecular interactions of ultrasmall metallic nanoparticles and nanoclusters“, © 2021 Alioscka A. Sousa et al., published by the Royal Society of Chemistry

Quantum-to-classical modeling of monolayer Ge₂Se₂ and its application in photovoltaic devices

• Anup Shrivastava,
• Shivani Saini,
• Dolly Kumari,
• Sanjai Singh and
• Jost Adam

Beilstein J. Nanotechnol. 2024, 15, 1153–1169, doi:10.3762/bjnano.15.94

• thicker absorber layer allows more photons to get absorbed, which leads to the generation of more electron–hole pairs. These generated electron–hole pairs, collected by the respective transport layers, contribute to the higher current density [58]. It is worth noticing that there is a significant impact

Photocatalytic methane oxidation over a TiO₂/SiNWs p–n junction catalyst at room temperature

• Qui Thanh Hoai Ta,
• Luan Minh Nguyen,
• Ngoc Hoi Nguyen,
• Phan Khanh Thinh Nguyen and
• Dai Hai Nguyen

Beilstein J. Nanotechnol. 2024, 15, 1132–1141, doi:10.3762/bjnano.15.92

• ]. Because of the different electron affinities (Eea,TiO2 ≈ 4.10 eV, Eea,Si ≈ 4.05 eV) [57][58] the electrons are excited and moved from the valance band minimum (VBM, 0.74V vs NHE) of SiNWs to the conduction band maximum (CBM, 0.35V vs NHE) of TiO2 to enter the equilibrium state under irradiation following

Recent updates in applications of nanomedicine for the treatment of hepatic fibrosis

• Damai Ria Setyawati,
• Fransiska Christydira Sekaringtyas,
• Riyona Desvy Pratiwi,
• A’liyatur Rosyidah,
• Rohimmahtunnissa Azhar,
• Nunik Gustini,
• Gita Syahputra,
• Idah Rosidah,
• Etik Mardliyati,
• Tarwadi and
• Sjaikhurrizal El Muttaqien

Beilstein J. Nanotechnol. 2024, 15, 1105–1116, doi:10.3762/bjnano.15.89

• pharmacologically inactive with minimal toxicity [58]. The increasing trend of liposomal formulations translated into clinical applications highlights the potency of liposomes as nanocarriers. Wang and co-workers utilized a phosphatidylserine for constructing curcumin-loaded lipid-based nanocarriers [59

Unveiling the potential of alginate-based nanomaterials in sensing technology and smart delivery applications

• Shakhzodjon Uzokboev,
• Khojimukhammad Akhmadbekov,
• Ra’no Nuritdinova,
• Salah M. Tawfik and
• Yong-Ill Lee

Beilstein J. Nanotechnol. 2024, 15, 1077–1104, doi:10.3762/bjnano.15.88

• ensure efficacy and safety [58]. The most crucial characteristics of nanoparticles are particle size, morphology, zeta potential, and surface area. Morphology of nanoparticles: There are many tools available for determining the morphology of nanomaterials. However, the most commonly used methods are

Effect of wavelength and liquid on formation of Ag, Au, Ag/Au nanoparticles via picosecond laser ablation and SERS-based detection of DMMP

• Sree Satya Bharati Moram,
• Chandu Byram and
• Venugopal Rao Soma

Beilstein J. Nanotechnol. 2024, 15, 1054–1069, doi:10.3762/bjnano.15.86

• during the ablation. He et al. [58] demonstrated that at higher NaCl (10 mM) concentrations, ZnO NPs exhibited coalescence, increasing NPs size in comparison to those obtained in DW. In Figure 3, TEM images depicting as-synthesized Au NPs under different incident laser wavelengths (i.e., (a) 355, (b) 532

Interface properties of nanostructured carbon-coated biological implants: an overview

• Mattia Bartoli,
• Francesca Cardano,
• Erik Piatti,
• Stefania Lettieri,
• Andrea Fin and
• Alberto Tagliaferro

Beilstein J. Nanotechnol. 2024, 15, 1041–1053, doi:10.3762/bjnano.15.85

• in 1991 [56]. CNTs can be described as single or multiple cylindrical graphite sheets rolled up in a tubular structure forming single-walled CNTs (SWCNTs) or multiwalled CNTs (MWCNTs). SWCNTs are characterized by diameters from 0.3 nm [57] to 1 nm [58], while the diameters of MWCNTs can reach 100 nm