C-5’-Triazolyl-2’-oxa-3’-aza-4’a-carbanucleosides: Synthesis and biological evaluation

Scholarly Works

• Adhikari, A.; Mandal, D.; Rana, D.; Nath, J.; Bose, A.; Sonika; Orasugh, J. T.; De, S.; Chattopadhyay, D. COVID-19 mitigation: nanotechnological intervention, perspective, and future scope. Materials Advances 2023, 4, 52–78. doi:10.1039/d2ma00797e
• Romeo, R.; Giofrè, S. V.; Chiacchio, M. A.; Veltri, L.; Celesti, C.; Iannazzo, D. Synthesis and Biological Evaluation of 2,3,4-Triaryl-1,2,4-oxadiazol-5-ones as p38 MAPK Inhibitors. Molecules (Basel, Switzerland) 2021, 26, 1745–1756. doi:10.3390/molecules26061745
• Štadániová, R.; Sahulčík, M.; Doháňošová, J.; Moncol, J.; Janotka, Ľ.; Šimoničová, K.; Messingerová, L.; Fischer, R. Synthesis of 1,2,3-Triazoles Bearing a 4-Hydroxyisoxazolidine Moiety from 4,5-Unsubstituted 2,3-Dihydroisoxazoles. European Journal of Organic Chemistry 2020, 2020, 4775–4786. doi:10.1002/ejoc.202000737
• Legnani, L.; Iannazzo, D.; Pistone, A.; Celesti, C.; Giofrè, S. V.; Romeo, R.; Di Pietro, A.; Visalli, G.; Fresta, M.; Bottino, P.; Blanco, I.; Chiacchio, M. A. Functionalized polyhedral oligosilsesquioxane (POSS) based composites for bone tissue engineering: synthesis, computational and biological studies. RSC advances 2020, 10, 11325–11334. doi:10.1039/d0ra01636e
• Chiacchio, M. A.; Legnani, L.; Campisi, A.; Paola, B.; giuseppe, l.; Iannazzo, D.; Veltri, L.; Giofrè, S. V.; Romeo, R. 1,2,4-Oxadiazole-5-ones as analogues of tamoxifen: synthesis and biological evaluation. Organic & biomolecular chemistry 2019, 17, 4892–4905. doi:10.1039/c9ob00651f
• Romeo, G.; Prezzavento, O.; Intagliata, S.; Pittalà, V.; Modica, M. N.; Marrazzo, A.; Turnaturi, R.; Parenti, C.; Chiechio, S.; Arena, E.; Campisi, A.; Sposito, G.; Salerno, L. Synthesis, in vitro and in vivo characterization of new benzoxazole and benzothiazole-based sigma receptor ligands. European journal of medicinal chemistry 2019, 174, 226–235. doi:10.1016/j.ejmech.2019.04.056
• Chavan, P. V.; Desai, U. V.; Wadgaonkar, P. P.; Tapase, S. R.; Kodam, K. M.; Choudhari, A. S.; Sarkar, D. Click chemistry based multicomponent approach in the synthesis of spirochromenocarbazole tethered 1,2,3-triazoles as potential anticancer agents. Bioorganic chemistry 2019, 85, 475–486. doi:10.1016/j.bioorg.2019.01.070
• Quadrelli, P. Cycloaddition reactions for anticancer compounds. Modern Applications of Cycloaddition Chemistry; Elsevier, 2019; pp 85–152. doi:10.1016/b978-0-12-815273-7.00002-2
• Srivastava, S.; Maikhuri, V. K.; Mathur, D.; Prasad, A. K. Recent Advances in Triazolyl Nucleosides. Green Chemistry in Environmental Sustainability and Chemical Education; Springer Singapore, 2018; pp 153–173. doi:10.1007/978-981-10-8390-7_16
• Amata, E.; Rescifina, A.; Prezzavento, O.; Arena, E.; Dichiara, M.; Pittalà, V.; Montilla-García, Á.; Punzo, F.; Merino, P.; Cobos, E. J.; Marrazzo, A. (+)-Methyl (1R,2S)-2-{[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]methyl}-1-phenylcyclopropanecarboxylate [(+)-MR200] Derivatives as Potent and Selective Sigma Receptor Ligands: Stereochemistry and Pharmacological Properties. Journal of medicinal chemistry 2017, 61, 372–384. doi:10.1021/acs.jmedchem.7b01584
• Amata, E.; Dichiara, M.; Arena, E.; Pittalà, V.; Pistarà, V.; Cardile, V.; Graziano, A. C. E.; Fraix, A.; Marrazzo, A.; Sortino, S.; Prezzavento, O. Novel Sigma Receptor Ligand–Nitric Oxide Photodonors: Molecular Hybrids for Double-Targeted Antiproliferative Effect. Journal of medicinal chemistry 2017, 60, 9531–9544. doi:10.1021/acs.jmedchem.7b00791
• Dichiara, M.; Prezzavento, O.; Marrazzo, A.; Pittalà, V.; Salerno, L.; Rescifina, A.; Amata, E. Recent advances in drug discovery of phototherapeutic non-porphyrinic anticancer agents. European journal of medicinal chemistry 2017, 142, 459–485. doi:10.1016/j.ejmech.2017.08.070
• Memeo, M. G.; Quadrelli, P. Generation and Trapping of Nitrosocarbonyl Intermediates. Chemical reviews 2017, 117, 2108–2200. doi:10.1021/acs.chemrev.6b00684
• Giofrè, S. V.; Cirmi, S.; Mancuso, R.; Nicolò, F.; Lanza, G.; Legnani, L.; Campisi, A.; Chiacchio, M. A.; Navarra, M.; Gabriele, B.; Romeo, R. Synthesis of spiro[isoindole-1,5'-isoxazolidin]-3(2H)-ones as potential inhibitors of the MDM2-p53 interaction. Beilstein journal of organic chemistry 2016, 12, 2793–2807. doi:10.3762/bjoc.12.278
• Olivieri, M.; Amata, E.; Vinciguerra, S.; Fiorito, J.; Giurdanella, G.; Drago, F.; Caporarello, N.; Prezzavento, O.; Arena, E.; Salerno, L.; Rescifina, A.; Lupo, G.; Anfuso, C. D.; Marrazzo, A. Antiangiogenic Effect of (±)-Haloperidol Metabolite II Valproate Ester [(±)-MRJF22] in Human Microvascular Retinal Endothelial Cells. Journal of medicinal chemistry 2016, 59, 9960–9966. doi:10.1021/acs.jmedchem.6b01039
• Gopalan, B.; Balasubramanian, K. K. Click Reactions in Organic Synthesis; Wiley, 2016; pp 25–76. doi:10.1002/9783527694174.ch2
• Chiacchio, U.; Broggini, G.; Romeo, R.; Gazzola, S.; Chiacchio, M. A.; Giofrè, S. V.; Gabriele, B.; Mancuso, R.; Floresta, G.; Zagni, C. Intramolecular oxidative palladium-catalyzed diamination reactions of alkenyl sulfamates: an efficient synthesis of [1,2,5]thiadiazolo-fused piperazinones. RSC Advances 2016, 6, 57521–57529. doi:10.1039/c6ra13141g
• Iannazzo, D.; Pistone, A.; Visco, A.; Galtieri, G.; Giofrè, S. V.; Romeo, R.; Romeo, G.; Cappello, S.; Bonsignore, M.; Denaro, R.; Galvagno, S. 1,2,3-Triazole/MWCNT conjugates as filler for gelcoat nanocomposites: new active antibiofouling coatings for marine application. Materials Research Express 2015, 2, 115001. doi:10.1088/2053-1591/2/11/115001
• D, I.; A, P.; R, R.; Giofrè, S. V. Nanotechnology Approaches for Antiretroviral Drugs Delivery. Journal of AIDS and HIV infections 2015, 1, 1. doi:10.15744/2454-499x.1.201
• Giofrè, S. V.; Romeo, R.; Carnovale, C.; Mancuso, R.; Cirmi, S.; Navarra, M.; Garozzo, A.; Chiacchio, M. A. Synthesis and biological properties of 5-(1H-1,2,3-triazol-4-yl)isoxazolidines: a new class of C-nucleosides. Molecules (Basel, Switzerland) 2015, 20, 5260–5275. doi:10.3390/molecules20045260

Explore citations to this article at