This paper reports a novel approach for the direct and facile synthesis of 1,2-oxyamino moieties via an intermolecular copper-catalyzed oxyamination of olefins. This strategy utilizes O-benzoylhydroxylamines as an electrophilic amine source and carboxylic acids as a nucleophilic oxygen source to achieve a modular difunctionalization of olefins. The reaction proceeded in a regioselective manner with moderate to good yields, exhibiting a broad scope of carboxylic acid, amine, and olefin substrates.
Keywords: copper; electrophilic amination; olefin oxyamination
The 1,2-oxyamino motif is highly valuable and found in a vast range of biologically active natural products, pharmaceuticals, and agrochemicals (Figure 1) [1,2]. Representative examples include salmeterol (Advair®), a β2-adrenergic receptor agonist ; lumefantrine, an antimalarial drug ; ifenprodil, an N-methyl-D-aspartate (NMDA) antagonist ; and tebuconazole, a commercial fungicide .
With the importance of 1,2-oxyamino motifs as privileged pharmacophores, the development of facile and efficient access to this class of molecules is highly valued. Toward this end, intermolecular olefin oxyamination allows for direct and modular installation of both oxygen and amino groups to readily available olefins in a single step, representing a powerful and appealing approach over multistep sequences [7-9]. Sharpless reported the first examples of this strategy using osmium tetroxide and amines to generate imido osmium intermediates (Scheme 1A) [10-12]. Although this transformation has received extensive application, the development of less toxic olefin oxyamination methods is greatly desired. In 2006, Stahl and Liu reported a palladium-catalyzed introduction of phthalimide (HNPhth) and acetate functionalities to terminal allylic and homoallylic ethers in the presence of an iodine oxidant (Scheme 1B) . The Yoon lab also developed copper- and iron-catalyzed olefin difunctionalization reactions with oxaziridine derivatives to create 1,3-oxazolidines, which were readily converted to the 1,2-oxyamino functionality (Scheme 1C) [14,15]. Recently, the Xu lab developed another iron-catalyzed intermolecular olefin-oxyamination reaction with O-alkylhydroxylamides to construct either 1,2-oxyamino or 2-oxazolidinone motifs (Scheme 1D) . Metal-free intermolecular oxyamination reactions have also been accomplished; examples were reported by the Zhu lab with the use of peroxides  and by the Studer lab with the use of hypervalent iodo-azide reagents . Furthermore, the intramolecular oxyamination of olefins with a tethered amino or oxygen functionality has been achieved for the construction of a variety of 1,2-oxyamino products, using palladium [19,20], platinum , gold , copper [23-26], free-radical initiators [27-29], hypervalent iodine , and electrochemical oxidation [31-33], as well as an analogous intramolecular electrophilic amino lactonization from our group .
Despite these important achievements, current intermolecular olefin oxyamination reactions are often restricted by the use of specific amino and oxygen precursors, limiting the structural diversity of 1,2-oxyamino products. For example, most oxyamination methods are limited to the installation of amide or sulfonamide derivatives. The direct installation of electron-rich amino groups, especially tertiary cyclic amines, remains an unsolved problem. Furthermore, most methods employ inflexible oxygen sources, such as TEMPO and acetate. Herein, we envisioned that a copper-catalyzed intermolecular olefin oxyamination could be achieved using O-acylhydroxylamines as an electrophilic amino precursor [35-39] and carboxylic acids as a nucleophilic oxygen source (Scheme 1E). The proposed transformation, integrating an electrophilic amination with a nucleophilic oxygenation, builds upon our recent development in copper-catalyzed olefin difunctionalization, such as copper-catalyzed diamination  and amino lactonization . This strategy overcomes common issues of chemo- and regioselectivity associated with adding two different nucleophiles and simultaneously eliminates the need for an external oxidant. Particularly advantageous is the direct addition of electron-rich amino groups, especially tertiary amines, which are difficult to access by other known methods. Furthermore, O-acylhydroxylamines are synthetically straightforward and benchtop stable, serving as attractive amine precursors [41,42]. Overall, the development of such a three-component transformation offers an appealing oxyamination strategy complementary to existing methods.
Our investigation began with the use of pentafluorobenzoic acid (1a) as the oxygen source and 4-benzoyloxymorpholine (3a) as the nitrogen source in the proposed intermolecular oxyamination of styrene (2a, Table 1). Copper was found to be effective and critical to promote the formation of oxyamination product 4a with excellent regioselectivity, as 4a was not observed in the absence of a catalyst (Table 1, entry 1). Among a variety of copper salts (Table 1, entries 2–7), Cu(OAc)2 proved superior as a catalyst (Table 1, entry 2). When the stoichiometry of each reactant was examined for this three-component transformation, decreasing the amount of 1a resulted in lower yields (Table 1, entry 2 vs 8), while decreasing the amount of 3a had no effect (Table 1, entry 2 vs 9). Increasing the amount of 2a led to a noticeable improvement (Table 1, entry 9 vs 12). Finally, the optimal conditions were established with three equivalents of both 1a and 2a, providing 4a in a clean 78% isolation yield (Table 1, entry 13) .
Table 1: Optimization of copper-catalyzed intermolecular oxyamination.a
|Entry||Reactants (equiv)||Catalyst||Timeb||4a (%)c|
|13||3||3||1||Cu(OAc)2||15 min||99 (78)d|
aReaction conditions: 1a, 2a, 3a, catalyst (20 mol %), DCE (1.0 mL), 80 °C. bTime required for consumption of 2a. cOnly the indicated isomer was observed. Yields determined by 1H NMR spectroscopy with CH2Br2 as a quantitative internal standard. dIsolated yield. OAc = acetate, OTf = trifluoromethanesulfonate, TFA = trifluoroacetate.
With established oxyamination conditions in hand, the scope of carboxylic acids in this transformation was examined using olefin 2a and O-benzoylhydroxylamine 3a (Scheme 2). Both aryl and alkyl carboxylic acid derivatives proved to be viable substrates, smoothly providing 1,2-oxyamino products 4a–g. Carboxylic acids containing a nitro group (4b), a halide group (4d), or an allyl group (4f) were tolerated, demonstrating the broad functional group compatibility of the reaction conditions. It is notable that higher efficiencies were observed in the reactions with more acidic benzoic acids, indicating a correlation of their reactivity to their acidity which remains to be further clarified . Furthermore, when trifluoroacetic acid was employed as an oxygen source, the free 1,2-amino alcohol 4g was isolated, possibly due to the labile hydrolysis of the trifluoroacetate group.
Next, the scope of O-benzoylhydroxylamines was examined with carboxylic acid 1a and olefin 2a (Scheme 3). In the reactions with cyclic O-benzoylhydroxylamines, 5a–c were readily formed in good yields, while acyclic amine products 5d and 5e were formed less effectively. Likely, the electronic and steric nature of the acyclic O-benzoylhydroxylamines may affect the stability of the corresponding amino intermediates, and result in facile breakdown of the amine precursors to the corresponding free amine. It should be noted that the benzyl group on the amine 5e can be readily cleaved for the construction of a secondary amine.
Finally, the scope of olefins for the transformation was examined including both aryl and alkyl olefins (Table 2). First, styrene derivatives bearing a variety of substitutions on the aryl ring, including both electron-donating and electron-withdrawing groups, were all effective in providing the 1,2-oxyaminated products with exclusive regioselectivity (Table 2, entries 1–6). Interestingly, the products derived from electron-rich styrene substrates (i.e., 6a, 6b, 6e) were formed in higher yields than those from electron-deficient ones (i.e., 6c and 6f). The reactions with simple olefins also provided desired products, yet in poor yields (Table 2, entries 7 and 8). These results indicate that olefin substrates capable of stabilizing a possible electron-deficient intermediate (carbon cation or radical) are likely favored in this transformation. Furthermore, 1,2-disubstituted olefins were also viable substrates (Table 2, entries 9–11). Particularly exciting is the formation of 6j and 6k in excellent diastereoselectivity. In contrast, acyclic 1,2-oxyamino product 6i was formed as a 1:1 mixture of two diastereomers. These results suggest a contribution of the structural conformation to the diastereoselective outcome of the reaction. Yet, 1,1-disubstituted olefins were not effective, likely due to the increased steric hindrance in the oxygenation step (Table 2, entry 12).
Table 2: Examples of olefins in intermolecular oxyamination reaction.a
6a, R = 2–OMe
6b, R = 3–OMe
6c, R = 3–F
6d, R = 4–Me
6e, R = 4–OMe
6f, R = 4–Cl
6g, R = CH2TMS
6h, R = TMS
|9||6i||69 (1:1 dr)c|
|10||6j||89 (7:1 dr)c|
|11||6k||35 (>20:1 dr)c|
aReaction conditions: 1a (1.2 mmol, 3.0 equiv), 2 (3.0 equiv), 3a (1.0 equiv), Cu(OAc)2 (20 mol %), DCE (2.0 mL), 80 °C, 15 min. bIsolated yields. cdr = diastereomeric ratio, determined by 1H NMR of the crude reaction mixture. Major diastereomer shown. Relative stereochemistry of 6j determined by X-ray analysis. dProduct containing minor inseparable impurities.
Currently, the mechanistic details of this copper-catalyzed oxyamination reaction remain unclear. In the control experiment with the absence of O-benzoylhydroxylamine, both carboxylic acid and olefin substrates were fully recovered, suggesting the critical role of O-benzoylhydroxylamine in the activation of copper catalyst for the initiation of this reaction. Further investigations are underway for a better understanding of the reaction pathway.
In summary, we have developed a copper-catalyzed three-component intermolecular oxyamination of olefins using carboxylic acids and O-benzoylhydroxylamines. This reaction allows for rapid access to a variety of 1,2-oxyamino products in a modular manner with excellent regioselectivity. It offers an appealing oxyamination method, especially for the construction of electron-rich tertiary amines. Future efforts will be undertaken for a better understanding of the reaction mechanism and for the development of an asymmetric version.
|Supporting Information File 1: Full experimental details, characterization data and crystallographic data for 6j.|
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