Recent advances in N-heterocyclic carbene (NHC)-catalysed benzoin reactions

Scholarly Works

• Zhang, Y.; Luo, Y.; Zhang, T.; Chen, M.; Xu, Y.; Sun, G.; Luo, S.; Zhu, Q. Enantioselective Synthesis of Inherently Chiral Tetraphenylene Analogues Enabled by NHC‐Catalyzed Benzoin Condensation. Angewandte Chemie 2026, 138. doi:10.1002/ange.6712761
• Zhang, Y.; Luo, Y.; Zhang, T.; Chen, M.; Xu, Y.; Sun, G.; Luo, S.; Zhu, Q. Enantioselective Synthesis of Inherently Chiral Tetraphenylene Analogues Enabled by NHC-Catalyzed Benzoin Condensation. Angewandte Chemie (International ed. in English) 2026, 65, e6712761. doi:10.1002/anie.6712761
• Anilkumar, B.; Sinha, P. K.; Nanubolu, J. B.; Suresh, S. N-Heterocyclic Carbene-Catalyzed Aza-Benzoin-Michael Addition-Lactamization Cascade Incorporating a Formal [4 + 1] Annulation to Access Tricyclic Indeno[2,1-b]pyrrole Derivatives. Organic letters 2026, 28, 5159–5164. doi:10.1021/acs.orglett.6c00999
• Dodke, V. S.; Solanke, J. N.; Gat, S.; Sharma, D.; Dandela, R.; Dhayalan, V. Synthetic Strategies Toward NHO-Metal Complexes and Applications in Synthesis and Catalysis. Chemistry, an Asian journal 2026, 21, e70724. doi:10.1002/asia.70724
• Lin, Y.-H.; Miljanić, O. Š. Cyclobenzoin Macrocycles: Guest Capture and Applications in Energy Technologies. Angewandte Chemie (International ed. in English) 2026, 65, e7124073. doi:10.1002/anie.7124073
• Lin, Y.; Miljanić, O. Š. Cyclobenzoin Macrocycles: Guest Capture and Applications in Energy Technologies. Angewandte Chemie 2026, 138. doi:10.1002/ange.7124073
• Niu, T.; Zhang, C.; Zhang, R.; Lou, X.; Gao, C.; Wang, Y.; Li, Q.; Wei, H.; Zhang, X.; Jiang, L.; Yang, T. Fluoroalkyl Acetaldehydes‐Versatile Fluorinated Building Blocks for the Synthesis of Diverse Fluoroalkylated Compounds. Asian Journal of Organic Chemistry 2026, 15. doi:10.1002/ajoc.70360
• Abe, H.; Sasaki, K.; Sakashita, C.; Watanabe, S.; Noda, H.; Watanabe, T.; Shibasaki, M. Catalytic Asymmetric Benzoin Condensation for the Synthesis of Natural Products and Their Analogs. Organic letters 2025, 27, 13702–13706. doi:10.1021/acs.orglett.5c04053
• Ono, K.; Fukumoto, J.; Tanoi, Y.; Kawai, H. Precipitation-driven diastereo- and regioselective macrocyclization via benzoin condensation: effects of solvents and alkyl chain lengths. Organic Chemistry Frontiers 2025, 12, 7162–7167. doi:10.1039/d5qo01179e
• Dhayalan, V. Visible-light-driven NHC and organophotoredox dual catalysis for the synthesis of carbonyl compounds. Beilstein journal of organic chemistry 2025, 21, 2584–2603. doi:10.3762/bjoc.21.200
• Onida, K.; Lusseau, J.; Duguet, N. Organocatalytic Synthesis of Vinylene Carbonates Using Dimethyl Carbonate as a Carbonyl Source. ChemCatChem 2025, 17. doi:10.1002/cctc.202501476
• Nath, P.; Deb, M. L.; Nath, J. K.; Baruah, P. K. Visible Light‐induced Organophotocatalytic Umpolung C(sp 3 )‐H Functionalization of Barbituric Acids. Asian Journal of Organic Chemistry 2025, 14. doi:10.1002/ajoc.70226
• Ling, D.; Ran, Y.; Yang, F.; Yang, X.; Wu, X.; Ren, S.-C.; Jin, Z. Advances in N-heterocyclic carbene organocatalysis from 2015 to 2024. Chemical Society reviews 2025, 54, 8725–8808. doi:10.1039/d5cs00600g
• Inishi, T.; Okamura, T.; Nishikata, T. Iron-catalyzed 1,2-diketone synthesis via benzoin condensation/oxidation in water. Tetrahedron Letters 2025, 168, 155717. doi:10.1016/j.tetlet.2025.155717
• Chang, Y.-C.; Guo, R.; Fessard, T.; Lefebvre, Q.; Salome, C.; Brown, M. K. Umpolung Activation of Bicyclobutanes via N-Heterocyclic Carbene Catalysis. Angewandte Chemie (International ed. in English) 2025, 64, e202513913. doi:10.1002/anie.202513913
• Chang, Y.; Guo, R.; Fessard, T.; Lefebvre, Q.; Salome, C.; Brown, M. K. Umpolung Activation of Bicyclobutanes via N‐Heterocyclic Carbene Catalysis. Angewandte Chemie 2025, 137. doi:10.1002/ange.202513913
• Sharma, D.; Solanke, J. N.; Gat, S.; Dhayalan, V.; Dandela, R. An Alternative Method for the Efficient Synthesis of Aminoindane‐Based Chiral Triazolium Salts. ChemistrySelect 2025, 10. doi:10.1002/slct.202503134
• Khazipova, O. V.; Khazipov, O. V.; Shepelenko, K. E.; Kashin, A. S.; Zhang, Y.; Chernyshev, V. M.; Ananikov, V. P. Ni/NHC-catalyzed C5-H alkylation and alkenylation of challenging furan(thiophene)-2-carboxaldehydes enabled by recyclable imine protecting group. Communications chemistry 2025, 8, 253. doi:10.1038/s42004-025-01653-5
• Ren, M.; Zhu, H.; Yang, S.; Li, R.; Dai, G.; Zhou, M.; Zhang, X.; Fu, Z. NHC-Catalyzed Enantioselective Access to Pyrazoles with a Nitrile-Containing All-Carbon Quaternary Center. The Journal of organic chemistry 2025, 90, 12017–12022. doi:10.1021/acs.joc.5c01269
• Dybowska, J.; Przydacz, A.; Olczyk, W.; Sieroń, L.; Skrzyńska, A.; Albrecht, Ł. Divergent hetero-[8+n] higher order cycloadditions of tropothione and enals catalyzed by N-heterocyclic carbenes. Chemical communications (Cambridge, England) 2025, 61, 12119–12122. doi:10.1039/d5cc02536b

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