Synthesis of oligonucleotides on a soluble support

Harri Lönnberg
Beilstein J. Org. Chem. 2017, 13, 1368–1387. https://doi.org/10.3762/bjoc.13.134

Cite the Following Article

Synthesis of oligonucleotides on a soluble support
Harri Lönnberg
Beilstein J. Org. Chem. 2017, 13, 1368–1387. https://doi.org/10.3762/bjoc.13.134

How to Cite

Lönnberg, H. Beilstein J. Org. Chem. 2017, 13, 1368–1387. doi:10.3762/bjoc.13.134

Download Citation

Citation data can be downloaded as file using the "Download" button or used for copy/paste from the text window below.
Citation data in RIS format can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Zotero.

Presentation Graphic

Picture with graphical abstract, title and authors for social media postings and presentations.
Format: PNG Size: 135.9 KB Download

Citations to This Article

Up to 20 of the most recent references are displayed here.

Scholarly Works

  • Schaudy, E.; Ibañez-Redín, G.; Parlar, E.; Somoza, M. M.; Lietard, J. Nonaqueous Oxidation in DNA Microarray Synthesis Improves the Oligonucleotide Quality and Preserves Surface Integrity on Gold and Indium Tin Oxide Substrates. Analytical chemistry 2024, 96, 2378–2386. doi:10.1021/acs.analchem.3c04166
  • Li, Q.; Yan, H. "Difficult" deoxyribonucleotide sequences in the solid-phase synthesis by the phosphoramidite chemistry. Nucleosides, nucleotides & nucleic acids 2023, 1–9. doi:10.1080/15257770.2023.2295478
  • Liang, Z.; Rosenqvist, P.; Pajuniemi, E.; Ora, M.; Heinonen, P.; Virta, P.; Oivanen, M. 5'‐O‐(2‐Isopropoxyprop‐2‐yl)‐protected Phosphoramidite Building Blocks in the Liquid Phase Oligonucleotide Synthesis. European Journal of Organic Chemistry 2023, 26. doi:10.1002/ejoc.202300614
  • Oberemok, V. V.; Puzanova, Y. V.; Novikov, I. A. The Biotechnological "Provence" of the Future Provided by Antisense Oligoilators and Olinscides for Horticulturae. Horticulturae 2023, 9, 896. doi:10.3390/horticulturae9080896
  • Gal'chinsky, N. V.; Yatskova, E. V.; Novikov, I. A.; Useinov, R. Z.; Kouakou, N. J.; Kouame, K. F.; Kra, K. D.; Sharmagiy, A. K.; Plugatar, Y. V.; Laikova, K. V.; Oberemok, V. V. Icerya purchasi Maskell (Hemiptera: Monophlebidae) Control Using Low Carbon Footprint Oligonucleotide Insecticides. International journal of molecular sciences 2023, 24, 11650. doi:10.3390/ijms241411650
  • Rosenqvist, P.; Saari, V.; Pajuniemi, E.; Gimenez Molina, A.; Ora, M.; Horvath, A.; Virta, P. Stereo-Controlled Liquid Phase Synthesis of Phosphorothioate Oligonucleotides on a Soluble Support. The Journal of organic chemistry 2023, 88, 10156–10163. doi:10.1021/acs.joc.3c01006
  • Graczyk, A.; Radzikowska-Cieciura, E.; Kaczmarek, R.; Pawlowska, R.; Chworos, A. Modified Nucleotides for Chemical and Enzymatic Synthesis of Therapeutic RNA. Current medicinal chemistry 2023, 30, 1320–1347. doi:10.2174/0929867330666221014111403
  • Miyazaki, Y.; Yoshida, A.; Okaniwa, T.; Miyauchi, K.; Ohkubo, A. Oligonucleotide Synthesis on Porous Glass Resins Containing Activators. Organic letters 2022, 24, 3807–3811. doi:10.1021/acs.orglett.2c01348
  • Oberemok, V. V.; Andreeva, O. A.; Laikova, K. V.; Novikov, I. A.; Kubyshkin, A. V. Post-genomic platform for development of oligonucleotide vaccines against RNA viruses: diamond cuts diamond. Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2022, 71, 729–739. doi:10.1007/s00011-022-01582-2
  • Matsuda, H.; Yoshida, E.; Shinoda, T.; Sato, K.; Hara, R. I.; Wada, T. Solution-phase synthesis of oligodeoxyribonucleotides using the H-phosphonate method with N-unprotected 5′-phosphite monomers. RSC advances 2021, 11, 38094–38107. doi:10.1039/d1ra06619f
  • Virta, P. More versatile synthesis of oligonucleotides. Science (New York, N.Y.) 2021, 373, 1196–1197. doi:10.1126/science.abk3478
  • Appy, L.; Peyrottes, S.; Roy, B. Supported Synthesis of Adenosine Nucleotides and Derivatives on a Benzene-Centered Tripodal Soluble Support. European Journal of Organic Chemistry 2021, 2022. doi:10.1002/ejoc.202100544
  • Johnston, C.; Hardacre, C.; Migaud, M. E. Applications of Mechanochemistry for the Synthesis of DNA on Ionic Liquid Supports. Chemistry–Methods 2021, 1, 382–388. doi:10.1002/cmtd.202100002
  • McKenzie, L. K.; El-Khoury, R.; Thorpe, J. D.; Damha, M. J.; Hollenstein, M. Recent progress in non-native nucleic acid modifications. Chemical Society reviews 2021, 50, 5126–5164. doi:10.1039/d0cs01430c
  • Suchsland, R.; Appel, B.; Virta, P.; Müller, S. Synthesis of fully protected trinucleotide building blocks on a disulphide-linked soluble support. RSC advances 2021, 11, 3892–3896. doi:10.1039/d0ra10941j
  • Otsuka, Y.; Li, G.; Takahashi, H.; Satoh, H.; Yamada, K. Synthesis of a Fluorescent Solvatochromic Resin Using Suzuki-Miyaura Cross-Coupling and Its Optical Waveguide Spectra to Measure the Solvent Polarity on the Surface. Materials (Basel, Switzerland) 2020, 13, 4483. doi:10.3390/ma13204483
  • Creusen, G.; Akintayo, C. O.; Schumann, K.; Walther, A. Scalable One-Pot-Liquid-Phase Oligonucleotide Synthesis for Model Network Hydrogels. Journal of the American Chemical Society 2020, 142, 16610–16621. doi:10.1021/jacs.0c05488
  • Catani, M.; De Luca, C.; Alcântara, J. M. G.; Manfredini, N.; Perrone, D.; Marchesi, E.; Weldon, R.; Müller-Späth, T.; Cavazzini, A.; Morbidelli, M.; Sponchioni, M. Oligonucleotides: Current Trends and Innovative Applications in the Synthesis, Characterization, and Purification. Biotechnology journal 2020, 15, 1900226. doi:10.1002/biot.201900226
  • Kim, J.; Narayana, A.; Patel, S.; Sahay, G. Advances in intracellular delivery through supramolecular self-assembly of oligonucleotides and peptides. Theranostics 2019, 9, 3191–3212. doi:10.7150/thno.33921
  • Molina, A. G.; Sanghvi, Y. S. Liquid-Phase Oligonucleotide Synthesis: Past, Present, and Future Predictions. Current protocols in nucleic acid chemistry 2019, 77, e82. doi:10.1002/cpnc.82

Patents

  • GAFFNEY PIERS ROBERT JAMES; LIVINGSTON ANDREW GUY. SOLUTION PHASE POLYMER SYNTHESIS. WO 2023062389 A1, April 20, 2023.
  • SCHANZENBACH CHRISTOPH; LIPINSKY NUNES JOAO; BRABETZ WERNER. OPTIMIZED OLIGONUCLEOTIDE TX PROBE FOR A MULTIPLEXING ANALYSIS OF NUCLEIC ACIDS AND A MULTIPLEXING METHOD. WO 2022219122 A1, Oct 20, 2022.
  • SCHANZENBACH CHRISTOPH; LIPINSKY NUNES JOAO; BRABETZ WERNER. OPTIMIZED OLIGONUCLEOTIDE TX PROBE FOR A MULTIPLEXING ANALYSIS OF NUCLEIC ACIDS AND A MULTIPLEXING METHOD. EP 4074839 A1, Oct 19, 2022.
  • HU FEICHI; LIU CHUNYAN; WU CHENG-HSIEN; LIN YONGLONG. SURFACE LINKER OF SEMICONDUCTOR CHIP, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF. WO 2022022480 A1, Feb 3, 2022.
  • YOUTE TENDOUNG JEAN-JACQUES; SERRE AUDREY. Procédés de synthèses en solution de macromolécules à partir d’unités de dérivés de glucides. FR 3111897 A1, Dec 31, 2021.
  • YOUTE TENDOUNG JEAN-JACQUES; SERRE AUDREY. METHOD FOR SYNTHESISING MACROMOLECULES IN SOLUTION FROM CARBOHYDRATE DERIVATIVE UNITS. WO 2021260562 A1, Dec 30, 2021.
  • TANAKA YUKI; KANO TOSHIFUMI. METHOD FOR PRODUCING NUCLEIC ACID OLIGOMER. WO 2021193954 A1, Sept 30, 2021.
  • OKAMOTO ITARU; FUJIHARA TSUYOSHI; NEYA MASAHIRO. OLIGONUCLEOTIDE DEPROTECTION METHOD. WO 2021045141 A1, March 11, 2021.
  • ZHAO JIANJUN; HU YI; FANG JING. CANCER TREATMENT BY MALAT1 INHIBITION. WO 2018191153 A1, Oct 18, 2018.
Other Beilstein-Institut Open Science Activities