Cite the Following Article
Synthesis of multi-lactose-appended β-cyclodextrin and its cholesterol-lowering effects in Niemann–Pick type C disease-like HepG2 cells
Keiichi Motoyama, Rena Nishiyama, Yuki Maeda, Taishi Higashi, Yoichi Ishitsuka, Yuki Kondo, Tetsumi Irie, Takumi Era and Hidetoshi Arima
Beilstein J. Org. Chem. 2017, 13, 10–18.
https://doi.org/10.3762/bjoc.13.2
How to Cite
Motoyama, K.; Nishiyama, R.; Maeda, Y.; Higashi, T.; Ishitsuka, Y.; Kondo, Y.; Irie, T.; Era, T.; Arima, H. Beilstein J. Org. Chem. 2017, 13, 10–18. doi:10.3762/bjoc.13.2
Download Citation
Citation data can be downloaded as file using the "Download" button or used for copy/paste from the text window
below.
Citation data in RIS format can be imported by all major citation management software, including EndNote,
ProCite, RefWorks, and Zotero.
Presentation Graphic
| Picture with graphical abstract, title and authors for social media postings and presentations. | ||
| Format: PNG | Size: 1.1 MB | Download |
Citations to This Article
Up to 20 of the most recent references are displayed here.
Scholarly Works
- Ryu, J.-H.; Zheng, W.; Yang, X.-H.; Elsaidi, H.; Diakur, J.; Wiebe, L. I. Synthesis and Preliminary Evaluation of an ASGPr-Targeted Polycationic β-Cyclodextrin Carrier for Nucleosides and Nucleotides. Pharmaceutics 2024, 16, 323. doi:10.3390/pharmaceutics16030323
- Ohashi, M.; Tamura, A.; Yui, N. Exploring Receptor Binding Affinities and Hepatic Cell Association of N-Acetyl-d-Galactosamine-Modified β-Cyclodextrin-Based Polyrotaxanes for Liver-Targeted Therapies. Biomacromolecules 2023, 24, 2327–2341. doi:10.1021/acs.biomac.3c00194
- Ishitsuka, Y.; Irie, T.; Matsuo, M. Cyclodextrins applied to the treatment of lysosomal storage disorders. Advanced drug delivery reviews 2022, 191, 114617. doi:10.1016/j.addr.2022.114617
- Nishida, T.; Yokoyama, R.; Kubohira, Y.; Maeda, Y.; Takeo, T.; Nakagata, N.; Takagi, H.; Ishikura, K.; Yanagihara, K.; Misumi, S.; Kishimoto, N.; Ishitsuka, Y.; Kondo, Y.; Irie, T.; Soga, M.; Era, T.; Onodera, R.; Higashi, T.; Motoyama, K. Lactose-Appended Hydroxypropyl-β-Cyclodextrin Lowers Cholesterol Accumulation and Alleviates Motor Dysfunction in Niemann-Pick Type C Disease Model Mice. ACS applied bio materials 2022, 5, 2377–2388. doi:10.1021/acsabm.2c00233
- Zakany, F.; Kovacs, T.; Szente, L.; Varga, Z. Cyclodextrins as promising therapeutics against cholesterol overload. Cholesterol; Elsevier, 2022; pp 927–967. doi:10.1016/b978-0-323-85857-1.00028-6
- Ishikura, K.; Yanagihara, K.; Takagi, H. Synthesis of branched cyclodextrins using activated carbon as a catalyst. Journal of Inclusion Phenomena and Macrocyclic Chemistry 2021, 101, 91–99. doi:10.1007/s10847-021-01089-z
- Wanibuchi, K.; Hosoda, K.; Amgalanbaatar, A.; Hirai, Y.; Shoji, M.; Shimomura, H. A short review, effect of dimethyl-β-cyclodextrin on the interaction between Helicobacter pylori and steroidal compounds. Heliyon 2021, 7, e06767. doi:10.1016/j.heliyon.2021.e06767
- Harvey, D. ANALYSIS OF CARBOHYDRATES AND GLYCOCONJUGATES BY MATRIX-ASSISTED LASER DESORPTION/IONIZATION MASS SPECTROMETRY: AN UPDATE FOR 2015-2016. Mass spectrometry reviews 2021, 40, 408–565. doi:10.1002/mas.21651
- Ercan, A.; Çelebier, M.; Öncül, S.; Varan, G.; Koçak, E.; Benito, J. M.; Bilensoy, E. Polycationic cyclodextrin nanoparticles induce apoptosis and affect antitumoral activity in HepG2 cell line: An evaluation at the molecular level. International journal of pharmaceutics 2021, 598, 120379. doi:10.1016/j.ijpharm.2021.120379
- Yokoyama, R.; Taharabaru, T.; Nishida, T.; Ohno, Y.; Maeda, Y.; Sato, M.; Ishikura, K.; Yanagihara, K.; Takagi, H.; Nakamura, T.; Ito, S.; Ohtsuki, S.; Arima, H.; Onodera, R.; Higashi, T.; Motoyama, K. Lactose-appended β-cyclodextrin as an effective nanocarrier for brain delivery. Journal of controlled release : official journal of the Controlled Release Society 2020, 328, 722–735. doi:10.1016/j.jconrel.2020.09.043
- Matencio, A.; Navarro-Orcajada, S.; González-Ramón, A.; García-Carmona, F.; López-Nicolás, J. M. Recent advances in the treatment of Niemann pick disease type C: A mini-review. International journal of pharmaceutics 2020, 584, 119440. doi:10.1016/j.ijpharm.2020.119440
- Alali, U.; Vallin, A.; Bil, A.; Khanchouche, T.; Mathiron, D.; Przybylski, C.; Beaulieu, R.; Kovensky, J.; Benazza, M.; Bonnet, V. The uncommon strong inhibition of α-glucosidase by multivalent glycoclusters based on cyclodextrin scaffolds. Organic & biomolecular chemistry 2019, 17, 7228–7237. doi:10.1039/c9ob01344j
- Maeda, Y.; Motoyama, K.; Nishiyama, R.; Higashi, T.; Onodera, R.; Nakamura, H.; Takeo, T.; Nakagata, N.; Yamada, Y.; Ishitsuka, Y.; Kondo, Y.; Irie, T.; Era, T.; Arima, H. In vivo Efficacy and Safety Evaluation of Lactosyl-β-cyclodextrin as a Therapeutic Agent for Hepatomegaly in Niemann-Pick Type C Disease. Nanomaterials (Basel, Switzerland) 2019, 9, 802. doi:10.3390/nano9050802
- Higashi, T. Cyclodextrin-Based Molecular Accessories for Drug Discovery and Drug Delivery. Chemical & pharmaceutical bulletin 2019, 67, 289–298. doi:10.1248/cpb.c18-00735
- Christoforides, E.; Papaioannou, A.; Bethanis, K. Crystal structure of the inclusion complex of cholesterol in β-cyclodextrin and molecular dynamics studies. Beilstein journal of organic chemistry 2018, 14, 838–848. doi:10.3762/bjoc.14.69
- Elamin, K. M.; Motoyama, K.; Higashi, T.; Yamashita, Y.; Tokuda, A.; Arima, H. Dual targeting system by supramolecular complex of folate-conjugated methyl-β-cyclodextrin with adamantane-grafted hyaluronic acid for the treatment of colorectal cancer. International journal of biological macromolecules 2018, 113, 386–394. doi:10.1016/j.ijbiomac.2018.02.149
- Higashi, T.; Iohara, D.; Motoyama, K.; Arima, H. Supramolecular Pharmaceutical Sciences: A Novel Concept Combining Pharmaceutical Sciences and Supramolecular Chemistry with a Focus on Cyclodextrin-Based Supermolecules. Chemical & pharmaceutical bulletin 2018, 66, 207–216. doi:10.1248/cpb.c17-00765
Patents
- ARIMA HIDETOSHI; MOTOYAMA KEIICHI; HIGASHI TAISHI; ONODERA RISAKO; YOKOYAMA RYOMA. BRAIN-PENETRATING LIGAND AND DRUG CARRIER. WO 2020138421 A1, July 2, 2020.