NMR reaction monitoring in flow synthesis

M. Victoria Gomez and Antonio de la Hoz
Beilstein J. Org. Chem. 2017, 13, 285–300. https://doi.org/10.3762/bjoc.13.31

Cite the Following Article

NMR reaction monitoring in flow synthesis
M. Victoria Gomez and Antonio de la Hoz
Beilstein J. Org. Chem. 2017, 13, 285–300. https://doi.org/10.3762/bjoc.13.31

How to Cite

Gomez, M. V.; de la Hoz, A. Beilstein J. Org. Chem. 2017, 13, 285–300. doi:10.3762/bjoc.13.31

Download Citation

Citation data can be downloaded as file using the "Download" button or used for copy/paste from the text window below.
Citation data in RIS format can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Zotero.

Presentation Graphic

Picture with graphical abstract, title and authors for social media postings and presentations.
Format: PNG Size: 393.4 KB Download

Citations to This Article

Up to 20 of the most recent references are displayed here.

Scholarly Works

  • Kaimal, N. M.; Osterland, T.; Drexler, H.; Beweries, T. From Olefin Coordination to Rh─N Bond Formation and Oxidative Addition: pH Effects in Rhodium α‐Methyl‐β‐Amidoitaconate Complexes. European Journal of Inorganic Chemistry 2026. doi:10.1002/ejic.70276
  • Robinson, A. D.; Hill-Casey, F.; Duckett, S. B.; Halse, M. E. Photochemical Pump, Benchtop NMR Probe Spectroscopy for Reaction Monitoring With paraHydrogen. Magnetic resonance in chemistry : MRC 2026. doi:10.1002/mrc.70124
  • Mains, K. M.; Palumbo, C. T.; Rigo, D.; Webber, M. S.; Rosetto, G.; Bao, S. T.; Carroll, A. L.; Meyer, N. R.; Benson, A. F.; Boyle, B. A.; Haugen, S. J.; Ingraham, M. A.; Alexander, W. G.; Silberman, M.; Myers, L. C.; Ramirez, K. J.; Sullivan, K. P.; Guss, A. M.; Salvachúa, D.; Román-Leshkov, Y.; Stahl, S. S.; Werner, A. Z.; Beckham, G. T. Lignin to adipic acid in a high-yield chemical and biological redox process. Nature 2026, 654, 668–675. doi:10.1038/s41586-026-10580-x
  • Dumez, J.-N.; Giraudeau, P.; Hintermair, U.; Junkers, T.; Silva Elipe, M. V. Flow NMR for chemical synthesis. Nature Reviews Methods Primers 2026, 6. doi:10.1038/s43586-026-00482-7
  • Sulzer, N.; Hone, C. A.; Kappe, C. O. Indirect hard modeling of low resolution benchtop NMR data for the kinetic fitting of a complex organic reaction. Reaction Chemistry & Engineering 2026, 11, 922–931. doi:10.1039/d5re00436e
  • Chen, J.; Zou, Y.; Liao, L.; Yang, B.; Xing, D.; Zhou, J.; Qian, X.; Liu, Y.; He, H.; Gao, S. Trends and Challenges in Multistep Continuous Flow Synthesis. JACS Au 2026, 6, 731–755. doi:10.1021/jacsau.5c01611
  • Martínez-Galero, N. X.; Galindo, D.; Pérez-Picaso, L.; Peña-Zarate, L. Participation of the Cyanide Group in the Reaction Mechanism of Benzoxazole Formation: Monitoring by Continuous Flow Cell NMR. In ECSOC 2025, MDPI, 2025; 9. doi:10.3390/ecsoc-29-26850
  • Nickels, S. L.; Lee, A.-L.; Vilela, F. EDA photochemistry using continuous flow. Journal of flow chemistry 2025, 15, 221–247. doi:10.1007/s41981-025-00362-3
  • Alem, A.; Poormehrabi, P.; Lins, J.; Pachernegg-Mair, L.; Bandl, C.; Ruiz, V.; Ventosa, E.; Spirk, S.; Gutmann, T. Monitoring chemical processes in redox flow batteries employing in situ and in operando analyses. Energy & Environmental Science 2025, 18, 7373–7401. doi:10.1039/d5ee01311a
  • Bazzoni, M.; Horbenko, Y.; El Sabbagh, N.; Marchand, A.; Grochowska‐Tatarczak, M.; Bernard, A.; Giraudeau, P.; Felpin, F.; Dumez, J. Fast Multidimensional Flow Nuclear Magnetic Resonance at High Field for Real‐Time Reaction Monitoring and Flow Synthesis. Chemistry–Methods 2025, 5. doi:10.1002/cmtd.202400061
  • Bocquelet, C.; Rougier, N.; Le, H.-N.; Veyre, L.; Thieuleux, C.; Melzi, R.; Purea, A.; Banks, D.; Kempf, J. G.; Stern, Q.; Vaneeckhaute, E.; Jannin, S. Boosting 1H and 13C NMR signals by orders of magnitude on a bench. Science advances 2024, 10, eadq3780. doi:10.1126/sciadv.adq3780
  • Vijaya Bhaskar, K.; Rashed, M.; Subrahmanya Bhat, K.; Lee, J.; Kim, K.-H.; Buruga, K. A continuous flow microreactor as a practical tool for the synthesis of active pharmaceutical ingredients. Process Safety and Environmental Protection 2024, 192, 437–449. doi:10.1016/j.psep.2024.09.122
  • Alimuddin, M.; Bernier, L.; Braganza, J. F.; Collins, M. R.; Ornelas, M.; Richardson, P. F.; Sach, N.; Shariff, D.; Wang, W.; Yanovsky, A. A Tool for Reaction Monitoring in Real Time, the Development of a "Walk-Up Automated Reaction Profiling" System. The Journal of organic chemistry 2024, 89, 17374–17381. doi:10.1021/acs.joc.4c02027
  • Bazzoni, M.; Régheasse, A.; Caytan, E.; Felpin, F.-X.; Giraudeau, P.; Bernard, A.; Adams, R. W.; Morris, G. A.; Nilsson, M.; Dumez, J.-N. Pure Shift NMR in Continuous Flow. Chemistry (Weinheim an der Bergstrasse, Germany) 2024, 31, e202403385. doi:10.1002/chem.202403385
  • Bereś, M. A.; Zhang, B.; Junkers, T.; Perrier, S. Kinetic investigation of photoiniferter-RAFT polymerization in continuous flow using inline NMR analysis. Polymer Chemistry 2024, 15, 3166–3175. doi:10.1039/d4py00409d
  • Robinson, A. D.; Hill-Casey, F.; Duckett, S. B.; Halse, M. E. Quantitative reaction monitoring using parahydrogen-enhanced benchtop NMR spectroscopy. Physical chemistry chemical physics : PCCP 2024, 26, 14317–14328. doi:10.1039/d3cp06221j
  • Herold, D.; Brauser, M.; Kind, J.; Thiele, C. M. Evolution of a Combined UV/Vis and NMR Setup with Fixed Pathlengths for Mass-limited Samples. Chemistry (Weinheim an der Bergstrasse, Germany) 2024, 30, e202304016. doi:10.1002/chem.202304016
  • Rávai, B.; Orosz, M. J.; Péterfi, O.; Galata, D. L.; Bálint, E. Flow chemical laboratory practice for undergraduate students: synthesis of paracetamol. Journal of Flow Chemistry 2023, 14, 409–415. doi:10.1007/s41981-023-00303-y
  • Schrecker, L.; Dickhaut, J.; Holtze, C.; Staehle, P.; Wieja, A.; Hellgardt, K.; Hii, K. K. (Mimi). An efficient multiparameter method for the collection of chemical reaction data via 'one-pot' transient flow. Reaction Chemistry & Engineering 2023, 8, 3196–3202. doi:10.1039/d3re00439b
  • Lhoste, C.; Bazzoni, M.; Bonnet, J.; Bernard, A.; Felpin, F.-X.; Giraudeau, P.; Dumez, J.-N. Broadband ultrafast 2D NMR spectroscopy for online monitoring in continuous flow. The Analyst 2023, 148, 5255–5261. doi:10.1039/d3an01165h
Other Beilstein-Institut Open Science Activities