Automated chemical synthesis
Prof. Ian R. Baxendale, Durham University
Dr. Marcus Baumann, Durham University
Dr. Richard Bourne, University of Leeds
This thematic issue presents significant research results in automated chemical synthesis and consists of four reviews, twelve full research papers, and one letter. The contributions to this issue cover a wide range of topics, including flow chemistry, laboratory robotics, glycan assembly, reactor design, and 3D printing.
See related thematic issues:
Integrated multistep flow synthesis
Automated glycan assembly of a S. pneumoniae serotype 3 CPS antigen
- Markus W. Weishaupt,
- Stefan Matthies,
- Mattan Hurevich,
- Claney L. Pereira,
- Heung Sik Hahm and
- Peter H. Seeberger
Beilstein J. Org. Chem. 2016, 12, 1440–1446, doi:10.3762/bjoc.12.139
Flow carbonylation of sterically hindered ortho-substituted iodoarenes
- Carl J. Mallia,
- Gary C. Walter and
- Ian R. Baxendale
Beilstein J. Org. Chem. 2016, 12, 1503–1511, doi:10.3762/bjoc.12.147
Catalytic Chan–Lam coupling using a ‘tube-in-tube’ reactor to deliver molecular oxygen as an oxidant
- Carl J. Mallia,
- Paul M. Burton,
- Alexander M. R. Smith,
- Gary C. Walter and
- Ian R. Baxendale
Beilstein J. Org. Chem. 2016, 12, 1598–1607, doi:10.3762/bjoc.12.156
The in situ generation and reactive quench of diazonium compounds in the synthesis of azo compounds in microreactors
- Faith M. Akwi and
- Paul Watts
Beilstein J. Org. Chem. 2016, 12, 1987–2004, doi:10.3762/bjoc.12.186
Development of a continuous process for α-thio-β-chloroacrylamide synthesis with enhanced control of a cascade transformation
- Olga C. Dennehy,
- Valérie M. Y. Cacheux,
- Benjamin J. Deadman,
- Denis Lynch,
- Stuart G. Collins,
- Humphrey A. Moynihan and
- Anita R. Maguire
Beilstein J. Org. Chem. 2016, 12, 2511–2522, doi:10.3762/bjoc.12.246
The digital code driven autonomous synthesis of ibuprofen automated in a 3D-printer-based robot
- Philip J. Kitson,
- Stefan Glatzel and
- Leroy Cronin
Beilstein J. Org. Chem. 2016, 12, 2776–2783, doi:10.3762/bjoc.12.276
Extrusion – back to the future: Using an established technique to reform automated chemical synthesis
- Deborah E. Crawford
Beilstein J. Org. Chem. 2017, 13, 65–75, doi:10.3762/bjoc.13.9
Solution-phase automated synthesis of an α-amino aldehyde as a versatile intermediate
- Hisashi Masui,
- Sae Yosugi,
- Shinichiro Fuse and
- Takashi Takahashi
Beilstein J. Org. Chem. 2017, 13, 106–110, doi:10.3762/bjoc.13.13
3D printed fluidics with embedded analytic functionality for automated reaction optimisation
- Andrew J. Capel,
- Andrew Wright,
- Matthew J. Harding,
- George W. Weaver,
- Yuqi Li,
- Russell A. Harris,
- Steve Edmondson,
- Ruth D. Goodridge and
- Steven D. R. Christie
Beilstein J. Org. Chem. 2017, 13, 111–119, doi:10.3762/bjoc.13.14
Diels–Alder reactions of myrcene using intensified continuous-flow reactors
- Christian H. Hornung,
- Miguel Á. Álvarez-Diéguez,
- Thomas M. Kohl and
- John Tsanaktsidis
Beilstein J. Org. Chem. 2017, 13, 120–126, doi:10.3762/bjoc.13.15
Self-optimisation and model-based design of experiments for developing a C–H activation flow process
- Alexander Echtermeyer,
- Yehia Amar,
- Jacek Zakrzewski and
- Alexei Lapkin
Beilstein J. Org. Chem. 2017, 13, 150–163, doi:10.3762/bjoc.13.18
Continuous-flow synthesis of highly functionalized imidazo-oxadiazoles facilitated by microfluidic extraction
- Ananda Herath and
- Nicholas D. P. Cosford
Beilstein J. Org. Chem. 2017, 13, 239–246, doi:10.3762/bjoc.13.26
NMR reaction monitoring in flow synthesis
- M. Victoria Gomez and
- Antonio de la Hoz
Beilstein J. Org. Chem. 2017, 13, 285–300, doi:10.3762/bjoc.13.31
A chemoselective and continuous synthesis of m-sulfamoylbenzamide analogues
- Arno Verlee,
- Thomas Heugebaert,
- Tom van der Meer,
- Pavel I. Kerchev,
- Frank Van Breusegem and
- Christian V. Stevens
Beilstein J. Org. Chem. 2017, 13, 303–312, doi:10.3762/bjoc.13.33
Continuous N-alkylation reactions of amino alcohols using γ-Al2O3 and supercritical CO2: unexpected formation of cyclic ureas and urethanes by reaction with CO2
- Emilia S. Streng,
- Darren S. Lee,
- Michael W. George and
- Martyn Poliakoff
Beilstein J. Org. Chem. 2017, 13, 329–337, doi:10.3762/bjoc.13.36
Continuous-flow processes for the catalytic partial hydrogenation reaction of alkynes
- Carmen Moreno-Marrodan,
- Francesca Liguori and
- Pierluigi Barbaro
Beilstein J. Org. Chem. 2017, 13, 734–754, doi:10.3762/bjoc.13.73
Automating multistep flow synthesis: approach and challenges in integrating chemistry, machines and logic
- Chinmay A. Shukla and
- Amol A. Kulkarni
Beilstein J. Org. Chem. 2017, 13, 960–987, doi:10.3762/bjoc.13.97
