Natural and redesigned wasp venom peptides with selective antitumoral activity

Marcelo D. T. Torres, Gislaine P. Andrade, Roseli H. Sato, Cibele N. Pedron, Tania M. Manieri, Giselle Cerchiaro, Anderson O. Ribeiro, Cesar de la Fuente-Nunez and Vani X. Oliveira Jr.
Beilstein J. Org. Chem. 2018, 14, 1693–1703. https://doi.org/10.3762/bjoc.14.144

Cite the Following Article

Natural and redesigned wasp venom peptides with selective antitumoral activity
Marcelo D. T. Torres, Gislaine P. Andrade, Roseli H. Sato, Cibele N. Pedron, Tania M. Manieri, Giselle Cerchiaro, Anderson O. Ribeiro, Cesar de la Fuente-Nunez and Vani X. Oliveira Jr.
Beilstein J. Org. Chem. 2018, 14, 1693–1703. https://doi.org/10.3762/bjoc.14.144

How to Cite

Torres, M. D. T.; Andrade, G. P.; Sato, R. H.; Pedron, C. N.; Manieri, T. M.; Cerchiaro, G.; Ribeiro, A. O.; de la Fuente-Nunez, C.; Oliveira, V. X., Jr.. Beilstein J. Org. Chem. 2018, 14, 1693–1703. doi:10.3762/bjoc.14.144

Download Citation

Citation data can be downloaded as file using the "Download" button or used for copy/paste from the text window below.
Citation data in RIS format can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Zotero.

Presentation Graphic

Picture with graphical abstract, title and authors for social media postings and presentations.
Format: PNG Size: 1.3 MB Download

Citations to This Article

Up to 20 of the most recent references are displayed here.

Scholarly Works

  • Fu, X.-Y.; Yin, H.; Chen, X.-T.; Yao, J.-F.; Ma, Y.-N.; Song, M.; Xu, H.; Yu, Q.-Y.; Du, S.-S.; Qi, Y.-K.; Wang, K.-W. Three Rounds of Stability-Guided Optimization and Systematical Evaluation of Oncolytic Peptide LTX-315. Journal of medicinal chemistry 2024, 67, 3885–3908. doi:10.1021/acs.jmedchem.3c02232
  • Ghadiri, N.; Javidan, M.; Sheikhi, S.; Taştan, Ö.; Parodi, A.; Liao, Z.; Tayybi Azar, M.; Ganjalıkhani-Hakemi, M. Bioactive peptides: an alternative therapeutic approach for cancer management. Frontiers in immunology 2024, 15, 1310443. doi:10.3389/fimmu.2024.1310443
  • Qu, B.; Yuan, J.; Liu, X.; Zhang, S.; Ma, X.; Lu, L. Anticancer activities of natural antimicrobial peptides from animals. Frontiers in microbiology 2024, 14, 1321386. doi:10.3389/fmicb.2023.1321386
  • Díaz-Gómez, J. L.; Martín-Estal, I.; Rivera-Aboytes, E.; Gaxiola-Muñíz, R. A.; Puente-Garza, C. A.; García-Lara, S.; Castorena-Torres, F. Biomedical applications of synthetic peptides derived from venom of animal origin: A systematic review. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023, 170, 116015. doi:10.1016/j.biopha.2023.116015
  • de Almeida Gomes, I.; da Lima, A. B.; da Silva Brito, D. M.; Almeida Lima, A.; de Oliveira, F. L.; Espino Zelaya, E. A.; Magalhães Rebello Alencar, L.; Castelo Branco de Souza Collares Maia, D.; Amaral de Moraes, M. E.; Pantoja Mesquita, F.; Noronha Souza, P. F.; Montenegro, R. C. Recalculating the Route: Repositioning Antimicrobial Peptides for Cancer Treatment. Chemistry & biodiversity 2023, 21, e202301840. doi:10.1002/cbdv.202301840
  • Bastos, V.; Pascoal, S.; Lopes, K.; Mortari, M.; Oliveira, H. Cytotoxic effects of Chartergellus communis wasp venom peptide against melanoma cells. Biochimie 2023, 216, 99–107. doi:10.1016/j.biochi.2023.10.015
  • Pedron, C. N.; Torres, M. D. T.; Oliveira, C. S.; Silva, A. F.; Andrade, G. P.; Wang, Y.; Pinhal, M. A. S.; Cerchiaro, G.; da Silva Junior, P. I.; da Silva, F. D.; Radhakrishnan, R.; de la Fuente-Nunez, C.; Oliveira Junior, V. X. Molecular hybridization strategy for tuning bioactive peptide function. Communications biology 2023, 6, 1067. doi:10.1038/s42003-023-05254-7
  • Sun, X.; Zhang, Q.; Kadier, K.; Hu, P.; Liu, X.; Liu, J.; Yan, Y.; Sun, C.; Yau, V.; Lowe, S.; Meng, M.; Liu, Z.; Zhou, M. Association between diabetes status and breast cancer in US adults: findings from the US National Health and Nutrition Examination Survey. Frontiers in endocrinology 2023, 14, 1059303. doi:10.3389/fendo.2023.1059303
  • Chi, Q.-N.; Jia, S.-X.; Yin, H.; Wang, L.-E.; Fu, X.-Y.; Ma, Y.-N.; Sun, M.-P.; Qi, Y.-K.; Li, Z.; Du, S.-S. Efficient synthesis and anticancer evaluation of spider toxin peptide LVTX-8-based analogues with enhanced stability. Bioorganic chemistry 2023, 134, 106451. doi:10.1016/j.bioorg.2023.106451
  • Soares, S.; Lopes, K. S.; Mortari, M.; Oliveira, H.; Bastos, V. Antitumoral potential of Chartergellus-CP1 peptide from Chartergellus communis wasp venom in two different breast cancer cell lines (HR+ and triple-negative). Toxicon : official journal of the International Society on Toxinology 2022, 216, 148–156. doi:10.1016/j.toxicon.2022.07.004
  • Luo, L.; Kamau, P. M.; Lai, R. Bioactive Peptides and Proteins from Wasp Venoms. Biomolecules 2022, 12, 527. doi:10.3390/biom12040527
  • A Al-Shammery, K.; Hozzein, W. N. Antibacterial activities of two potential peptides extracted from Polistes wattii Cameron, 1900 (Vespidae: Polistinae) wasp venom collected at Eastern Province, Saudi Arabia. PloS one 2022, 17, e0264035. doi:10.1371/journal.pone.0264035
  • Chen, C. H.; Liu, Y.-H.; Eskandari, A.; Ghimire, J.; Lin, L. C.-W.; Fang, Z.-S.; Wimley, W. C.; Ulmschneider, J. P.; Suntharalingam, K.; Hu, C.-M. J.; Ulmschneider, M. B. Integrated Design of a Membrane-Lytic Peptide-Based Intravenous Nanotherapeutic Suppresses Triple-Negative Breast Cancer. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022, 9, e2105506. doi:10.1002/advs.202105506
  • Trinidad-Calderón, P. A.; Varela-Chinchilla, C. D.; García-Lara, S. Natural Peptides Inducing Cancer Cell Death: Mechanisms and Properties of Specific Candidates for Cancer Therapeutics. Molecules (Basel, Switzerland) 2021, 26, 7453. doi:10.3390/molecules26247453
  • Campos, J. F.; dos Santos, H. F.; Bonamigo, T.; de Campos Domingues, N. L.; de Picoli Souza, K.; dos Santos, E. L. Stingless Bee Propolis: New Insights for Anticancer Drugs. Oxidative medicine and cellular longevity 2021, 2021, 2169017. doi:10.1155/2021/2169017
  • de Oliveira, C. S.; Torres, M. D. T.; Pedron, C. N.; Andrade, V. B.; da Silva, P. I.; da Silva, F. D.; de la Fuente-Nunez, C.; Oliveira, V. X. Synthetic Peptide Derived from Scorpion Venom Displays Minimal Toxicity and Anti-infective Activity in an Animal Model. ACS infectious diseases 2021, 7, 2736–2745. doi:10.1021/acsinfecdis.1c00261
  • Martins, D. B.; Fadel, V.; Oliveira, F. D.; Gaspar, D.; Alvares, D. S.; Castanho, M. A. R. B.; dos Santos Cabrera, M. P. Protonectin peptides target lipids, act at the interface and selectively kill metastatic breast cancer cells while preserving morphological integrity. Journal of colloid and interface science 2021, 601, 517–530. doi:10.1016/j.jcis.2021.05.115
  • Giribaldi, J.; Smith, J. J.; Schroeder, C. I. Recent developments in animal venom peptide nanotherapeutics with improved selectivity for cancer cells. Biotechnology advances 2021, 50, 107769. doi:10.1016/j.biotechadv.2021.107769
  • Eghtedari, M.; Porzani, S. J.; Nowruzi, B. Anticancer potential of natural peptides from terrestrial and marine environments: A review. Phytochemistry Letters 2021, 42, 87–103. doi:10.1016/j.phytol.2021.02.008
  • El-Wahed, A. A.; Yosri, N.; Sakr, H. H.; Du, M.; Algethami, A. F. M.; Zhao, C.; Abdelazeem, A. H.; Tahir, H. E.; Masry, S. H. D.; Abdel-Daim, M. M.; Musharraf, S. G.; El-Garawani, I.; Kai, G.; Al Naggar, Y.; Khalifa, S. A. M.; El-Seedi, H. R. Wasp Venom Biochemical Components and Their Potential in Biological Applications and Nanotechnological Interventions. Toxins 2021, 13, 206. doi:10.3390/toxins13030206
Other Beilstein-Institut Open Science Activities