5-Aminopyrazole as precursor in design and synthesis of fused pyrazoloazines

Scholarly Works

• Zhang, Z.; Li, R.-P.; Gong, X.; Zhang, W.; Tang, S. Dithiane-initiated cascade to eight-membered sulfur-containing pyrazoles via decarboxylative aromatization. Chemical communications (Cambridge, England) 2025, 61, 12401–12404. doi:10.1039/d5cc03170b
• Shehab, W. S.; Magdy, N.; Elhoseni, M. A.; Assy, M. G.; AbdEl-Azim, M. H.; Mesbah, A. E.; El-Shwiniy, W. H.; Amer, M. M.; Elsayed, D. A. Design, synthesis and characterization of new fused pyrazole systems: In Vitro anti-bacterial, anti-fungal, antioxidant evaluation, In Silico DFT and molecular docking studies. Journal of Molecular Structure 2025, 1337, 142163. doi:10.1016/j.molstruc.2025.142163
• Hasan, M.; Peshkov, A. A.; Shah, S. A. A.; Belyaev, A.; Lim, C.-K.; Wang, S.; Peshkov, V. A. Silver(I) triflate-catalyzed post-Ugi synthesis of pyrazolodiazepines. Beilstein journal of organic chemistry 2025, 21, 915–925. doi:10.3762/bjoc.21.74
• Hostalet-Romero, J.; Carceller-Ferrer, L.; Blay, G.; Sanz-Marco, A.; Pedro, J. R.; Vila, C. Vinylogous functionalization of 4-alkylidene-5-aminopyrazoles with methyl trifluoropyruvates. Beilstein journal of organic chemistry 2025, 21, 533–540. doi:10.3762/bjoc.21.41
• Nguyen, Y.; Petruncio, G.; Noble, S. M.; Paige, M. Synthesis of 1H-pyrazolo[3,4-b]pyridine analogues. Results in Chemistry 2025, 14, 102075. doi:10.1016/j.rechem.2025.102075
• Odeh, D. M.; Odeh, M. M.; Hafez, T. S.; Hassan, A. S. Bioactive Fused Pyrazoles Inspired by the Adaptability of 5-Aminopyrazole Derivatives: Recent Review. Molecules (Basel, Switzerland) 2025, 30, 366. doi:10.3390/molecules30020366
• Dmitrieva, I. G.; Vasilin, V. K.; Dotsenko, V. V.; Aksenov, N. A. 6-(Pyrazol-1-yl)pyrazolo[3,4-b]pyridines: Synthesis, Structure, and Wheat Growth Regulating Activity. Russian Journal of General Chemistry 2024, 94, 2603–2615. doi:10.1134/s1070363224100050
• Blay, G.; Monleón, A.; Montesinos-Magraner, M.; Sanz-Marco, A.; Vila, C. Asymmetric electrophilic functionalization of amino-substituted heteroaromatic compounds: a convenient tool for the enantioselective synthesis of nitrogen heterocycles. Chemical communications (Cambridge, England) 2024, 60, 12270–12286. doi:10.1039/d4cc03680h
• Kudryavtseva, E. N.; Lichitsky, B. V.; Komogortsev, A. N.; Milyutin, C. V.; Tretyakov, E. V. The Study of Reaction of Hexafluoro‐1,4‐Napthoquinone With Substituted 5‐Aminopyrazoles. Journal of Heterocyclic Chemistry 2024, 61, 1932–1941. doi:10.1002/jhet.4911
• Alam Mondal, M.; Ghosh, R. Tailor‐Made Pyrazolopyridines and Fused Pyrazolopyridines: Recent Updates toward Sustainable Synthesis. ChemistrySelect 2024, 9. doi:10.1002/slct.202402738
• Singh, S.; Singh, K.; Tahlan, S. A comprehensive review on synthetic strategy and MOA of marketed drugs having therapeutically potential chemical entity pyrazole. Journal of the Iranian Chemical Society 2024, 21, 2531–2564. doi:10.1007/s13738-024-03095-7
• Kapri, A.; Gupta, N.; Nain, S. Therapeutic Potential of Pyrazole Containing Compounds: an Updated Review. Pharmaceutical Chemistry Journal 2024, 58, 252–267. doi:10.1007/s11094-024-03141-x
• Cuervo-Prado, P.; Orozco-López, F.; Becerra-Rivas, C.; Leon-Vargas, D.; Lozano-Oviedo, J.; Cobo, J. Regioselective Synthesis of Cycloalkane-fused Pyrazolo[4,3-e]pyridines through Tandem Reaction of 5-aminopyrazoles, Cyclic Ketones and Electron-rich Olefins. Current organic synthesis 2024, 21, 947–956. doi:10.2174/0115701794269765231204064930
• Michel, M.; Caré, F.; Bourg, S.; Bostyn, S.; Lafite, P.; Routier, S.; Buron, F. Access to Mono‐, Di‐ and Tri‐(Het)Arylated Pyrazolo[5,1‐b]oxazoles Using Cyclization, C−H Activation and Suzuki–Miyaura Palladium‐Catalyzed Reactions. European Journal of Organic Chemistry 2023, 27. doi:10.1002/ejoc.202301040
• Abo-Neima, S. E.; El-Sheekh, M. M.; Keshk, R. M. Synthesis and In Vivo Evaluation of Pyrazolopyridine and Pyridopyrazolopyrimidine Derivatives as Potent Anticancer Agents Against Ehrlich Ascites Carcinoma. BioNanoScience 2023, 13, 2385–2399. doi:10.1007/s12668-023-01199-7
• Munir, R.; Zaib, S.; Khan, I.; Islam, Z. t.; Gomila, R. M.; McAdam, C. J.; Yeow, C. H. S.; White, J. M.; Hökelek, T.; Al-Askar, A. A.; Elkaeed, E. B.; Frontera, A. Complex interplay of hydrogen bonding, halogen bonding and π-interactions in methyl 2-(7-chloro-1H-pyrazolo[3,4-b]quinolin-1-yl)acetate: Synthesis, X-ray crystallography, energetic features and anti-urease efficacy. Journal of Molecular Structure 2023, 1287, 135625. doi:10.1016/j.molstruc.2023.135625
• Rizbayeva, T. S.; Smolobochkin, A. V.; Gazizov, A. S.; Voronina, J. K.; Syakaev, V. V.; Gerasimova, D. P.; Lodochnikova, O. A.; Efimov, S. V.; Klochkov, V. V.; Burilov, A. R.; Pudovik, M. A. One-Step Synthesis of Functionalized Pyrazolo[3,4-b]pyridines via Ring Opening of the Pyrrolinium Ion. The Journal of organic chemistry 2023, 88, 11855–11866. doi:10.1021/acs.joc.3c01138
• Guirado, A.; Vera, M.; Martiz, B.; Ródenas, F.; Bautista, D.; Gálvez, J. New synthetic approach to pyrazolo[1,5‐a]pyrazine derivatives from 2,2‐dichlorovinylacetophenones. Journal of Heterocyclic Chemistry 2023, 60, 1714–1726. doi:10.1002/jhet.4712
• Гарибян, В. К. Синтез аминометилиденовых ациклических производных 1-замещенных пиразолов. Chemical Journal of Armenia 2023, 120–128. doi:10.54503/0515-9628-2023.76.1-2-120
• Pavilek, B.; Bortňák, D.; Šofranko, J.; Šofranková, L.; Špaldová, J.; Elefantová, K.; Olejníková, P.; Žídeková, I.; Végh, D.; Dokupilová, S.; Mikuš, P.; Breier, A.; Milata, V. Synthesis of Pyrazoloazepines from 5‐Aminopyrazoles and Study of Their Cytotoxicity in Cancer Treatment. European Journal of Organic Chemistry 2023, 26. doi:10.1002/ejoc.202300410

Explore citations to this article at