Synthesis of 3-aminocoumarin-N-benzylpyridinium conjugates with nanomolar inhibitory activity against acetylcholinesterase

Nisachon Khunnawutmanotham, Cherdchai Laongthipparos, Patchreenart Saparpakorn, Nitirat Chimnoi and Supanna Techasakul
Beilstein J. Org. Chem. 2018, 14, 2545–2552. https://doi.org/10.3762/bjoc.14.231

Supporting Information

Supporting Information File 1: Experimental details, characterization data and copies of NMR spectra.
Format: PDF Size: 1.0 MB Download

Cite the Following Article

Synthesis of 3-aminocoumarin-N-benzylpyridinium conjugates with nanomolar inhibitory activity against acetylcholinesterase
Nisachon Khunnawutmanotham, Cherdchai Laongthipparos, Patchreenart Saparpakorn, Nitirat Chimnoi and Supanna Techasakul
Beilstein J. Org. Chem. 2018, 14, 2545–2552. https://doi.org/10.3762/bjoc.14.231

How to Cite

Khunnawutmanotham, N.; Laongthipparos, C.; Saparpakorn, P.; Chimnoi, N.; Techasakul, S. Beilstein J. Org. Chem. 2018, 14, 2545–2552. doi:10.3762/bjoc.14.231

Download Citation

Citation data can be downloaded as file using the "Download" button or used for copy/paste from the text window below.
Citation data in RIS format can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Zotero.

Presentation Graphic

Picture with graphical abstract, title and authors for social media postings and presentations.
Format: PNG Size: 393.1 KB Download

Citations to This Article

Up to 20 of the most recent references are displayed here.

Scholarly Works

  • Khunnawutmanotham, N.; Sooknual, P.; Batsomboon, P.; Ploypradith, P.; Chimnoi, N.; Patigo, A.; Saparpakorn, P.; Techasakul, S. Synthesis, Antiacetylcholinesterase Activity, and Molecular Dynamics Simulation of Aporphine-benzylpyridinium Conjugates. ACS medicinal chemistry letters 2023, 15, 132–142. doi:10.1021/acsmedchemlett.3c00467
  • Vignaux, P. A.; Lane, T. R.; Urbina, F.; Gerlach, J.; Puhl, A. C.; Snyder, S. H.; Ekins, S. Validation of Acetylcholinesterase Inhibition Machine Learning Models for Multiple Species. Chemical research in toxicology 2023, 36, 188–201. doi:10.1021/acs.chemrestox.2c00283
  • Patra, P.; Manna, S.; Patra, S.; Samanta, K. The synthesis, biological evaluation, and fluorescence study of 3-aminocoumarin and their derivatives: a brief review. Monatshefte für Chemie - Chemical Monthly 2023, 154, 1–31. doi:10.1007/s00706-022-03010-x
  • Sepehri, S.; Saeedi, M.; Larijani, B.; Mahdavi, M. Recent developments in the design and synthesis of benzylpyridinium salts: Mimicking donepezil hydrochloride in the treatment of Alzheimer's disease. Frontiers in chemistry 2022, 10, 936240. doi:10.3389/fchem.2022.936240
  • Krajňáková, J.; Joniak, J.; Putala, M.; Górová, R.; Jurdáková, H.; Stankovičová, H. Mild and highly efficient deacetylation of acetamido and acetoxy coumarins: A convenient and expeditious synthesis of substituted 3-aminocoumarins. Synthetic Communications 2021, 51, 3277–3291. doi:10.1080/00397911.2021.1968904
  • Gupta, M.; Ojha, M.; Yadav, D.; Pant, S.; Yadav, R. Novel Benzylated (Pyrrolidin-2-one)/(Imidazolidin-2-one) Derivatives as Potential Anti-Alzheimer's Agents: Synthesis and Pharmacological Investigations. ACS chemical neuroscience 2020, 11, 2849–2860. doi:10.1021/acschemneuro.0c00403
  • Mahajan, S.; Slathia, N.; Kapoor, K. K. Beckmann rearrangement: Thiamine hydrochloride as a remarkable catalyst for one-pot synthesis of amides from ketones. Tetrahedron Letters 2020, 61, 151859. doi:10.1016/j.tetlet.2020.151859
Other Beilstein-Institut Open Science Activities