Targeting the Pseudomonas quinolone signal quorum sensing system for the discovery of novel anti-infective pathoblockers

Scholarly Works

• Jacobs, C. S.; Naicker, R.; Chenia, H. Y. Quorum Sensing Inhibition by Sponge-Associated Bacillus Species: Suppressing Pseudomonas aeruginosa Virulence Factors. Antibiotics (Basel, Switzerland) 2025, 14, 1035. doi:10.3390/antibiotics14101035
• Song, W.; Tian, Z.; Wang, Y.; Yin, Y.; Zhang, H.; Xu, C.; Shen, L. Isoliquiritigenin targets las, rhl, and Pqs quorum sensing systems to mitigate the virulence and infection of Pseudomonas aeruginosa. BMC microbiology 2025, 25, 580. doi:10.1186/s12866-025-04298-5
• Dweba, Y.; S'thebe, N. W.; Balogun, F. O.; Sabiu, S. Phenolics as Novel Quorum Sensing Inhibitors: Evidence from Computational and Experimental Studies. Natural Products; Springer Berlin Heidelberg, 2025; pp 1–41. doi:10.1007/978-3-642-36202-6_255-1
• Zhang, B.; Yang, M.; Liu, W. Integrating multi-omics analysis unveils the key mechanisms of PQS-enhanced Algicidal activity in Enterobacter hormaechei F2. Genomics 2025, 117, 111060. doi:10.1016/j.ygeno.2025.111060
• Valastyan, J. S.; Shine, E. E.; Mook, R. A.; Bassler, B. L. Inhibitors of the PqsR Quorum-Sensing Receptor Reveal Differential Roles for PqsE and RhlI in Control of Phenazine Production. ACS chemical biology 2025, 20, 1273–1287. doi:10.1021/acschembio.5c00114
• Spaggiari, C.; Yamukujije, C.; Pieroni, M.; Annunziato, G. Quorum sensing inhibitors (QSIs): a patent review (2019-2023). Expert opinion on therapeutic patents 2025, 35, 657–673. doi:10.1080/13543776.2025.2491382
• Kallergis, G.; Asgari, E.; Empting, M.; Hirsch, A. K. H.; Klawonn, F.; McHardy, A. C. Domain adaptable language modeling of chemical compounds identifies potent pathoblockers for Pseudomonas aeruginosa. Communications chemistry 2025, 8, 114. doi:10.1038/s42004-025-01484-4
• Valastyan, J. S.; Shine, E. E.; Mook, R. A.; Bassler, B. L. Inhibitors of the PqsR Quorum-Sensing Receptor Reveal Differential Roles for PqsE and RhlI in Control of Phenazine Production. 2025. doi:10.1101/2025.02.10.637488
• Mangal, S.; Singh, V.; Chhibber, S.; Harjai, K. Headway in Synthetic Chemistry: A Gateway for Antimicrobial Trojan Horse Strategy for Drug Repurposing Against Multi-Drug Resistant Pseudomonas aeruginosa. Indian journal of microbiology 2025, 65, 798–819. doi:10.1007/s12088-024-01439-8
• Milli, G.; Pellegrini, A.; Listro, R.; Fasolini, M.; Pagano, K.; Ragona, L.; Pietrocola, G.; Linciano, P.; Collina, S. New LsrK Ligands as AI-2 Quorum Sensing Interfering Compounds against Biofilm Formation. Journal of medicinal chemistry 2024, 67, 18139–18156. doi:10.1021/acs.jmedchem.4c01266
• Boakye, A.; Seidu, M. P.; Adomako, A.; Laryea, M. K.; Borquaye, L. S. Marine-Derived Furanones Targeting Quorum-Sensing Receptors in Pseudomonas aeruginosa: Molecular Insights and Potential Mechanisms of Inhibition. Bioinformatics and biology insights 2024, 18, 11779322241275843. doi:10.1177/11779322241275843
• Rodríguez-Urretavizcaya, B.; Vilaplana, L.; Marco, M.-P. Strategies for quorum sensing inhibition as a tool for controlling Pseudomonas aeruginosa infections. International journal of antimicrobial agents 2024, 64, 107323. doi:10.1016/j.ijantimicag.2024.107323
• Angelov, P.; Mollova-Sapundzhieva, Y.; Nedialkov, P. Attempted Synthesis of the Pseudomonas aeruginosa Metabolite 2-Benzyl-4(1H)-quinolone and Formation of 3-Methylamino-2-(2-nitrobenzoyl)-4H-naphthalen-1-one as an Unexpected Product. Molbank 2024, 2024, M1877. doi:10.3390/m1877
• Abdelsamie, A. S.; Hamed, M. M.; Schütz, C.; Röhrig, T.; Kany, A. M.; Schmelz, S.; Blankenfeldt, W.; Hirsch, A. K. H.; Hartmann, R. W.; Empting, M. Discovery and optimization of thiazole-based quorum sensing inhibitors as potent blockers of Pseudomonas aeruginosa pathogenicity. European journal of medicinal chemistry 2024, 276, 116685. doi:10.1016/j.ejmech.2024.116685
• Teja, P. K.; Ranjan, S.; Takamizawa, S. Twinning Organosuperelasticity in a 4-Nitroanthranilic Acid Solvate Crystal. Crystal Growth & Design 2024, 24, 4306–4311. doi:10.1021/acs.cgd.3c01168
• Ammazzalorso, A.; Granese, A.; De Filippis, B. Recent trends and challenges to overcome Pseudomonas aeruginosa infections. Expert opinion on therapeutic patents 2024, 34, 493–509. doi:10.1080/13543776.2024.2348602
• Vieira, T. F.; Leitão, M. M.; Cerqueira, N. M. F. S. A.; Sousa, S. F.; Borges, A.; Simões, M. Montelukast and cefoperazone act as antiquorum sensing and antibiofilm agents against Pseudomonas aeruginosa. Journal of applied microbiology 2024, 135. doi:10.1093/jambio/lxae088
• Elfadadny, A.; Ragab, R. F.; AlHarbi, M.; Badshah, F.; Ibáñez-Arancibia, E.; Farag, A.; Hendawy, A. O.; De Los Ríos-Escalante, P. R.; Aboubakr, M.; Zakai, S. A.; Nageeb, W. M. Antimicrobial resistance of Pseudomonas aeruginosa: navigating clinical impacts, current resistance trends, and innovations in breaking therapies. Frontiers in microbiology 2024, 15, 1374466. doi:10.3389/fmicb.2024.1374466
• Deery, J.; Carmody, M.; Flavin, R.; Tomanek, M.; O'Keeffe, M.; McGlacken, G. P.; Reen, F. J. Comparative genomics reveals distinct diversification patterns among LysR-type transcriptional regulators in the ESKAPE pathogen Pseudomonas aeruginosa. Microbial genomics 2024, 10. doi:10.1099/mgen.0.001205
• Adouane, E.; Mercier, C.; Mamelle, J.; Willocquet, E.; Intertaglia, L.; Burgunter-Delamare, B.; Leblanc, C.; Rousvoal, S.; Lami, R.; Prado, S. Importance of quorum sensing crosstalk in the brown alga Saccharina latissima epimicrobiome. iScience 2024, 27, 109176. doi:10.1016/j.isci.2024.109176

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