Non-native autoinducer analogs capable of modulating the SdiA quorum sensing receptor in Salmonella enterica serovar Typhimurium

Matthew J. Styles and Helen E. Blackwell
Beilstein J. Org. Chem. 2018, 14, 2651–2664. https://doi.org/10.3762/bjoc.14.243

Supporting Information

Supporting Information File 1: Compound library structures and screening results.
Format: PDF Size: 669.4 KB Download
Supporting Information File 2: Full dose–response curves.
Format: PDF Size: 716.9 KB Download
Supporting Information File 3: Competition assay efficacy and potency data.
Format: PDF Size: 94.2 KB Download

Cite the Following Article

Non-native autoinducer analogs capable of modulating the SdiA quorum sensing receptor in Salmonella enterica serovar Typhimurium
Matthew J. Styles and Helen E. Blackwell
Beilstein J. Org. Chem. 2018, 14, 2651–2664. https://doi.org/10.3762/bjoc.14.243

How to Cite

Styles, M. J.; Blackwell, H. E. Beilstein J. Org. Chem. 2018, 14, 2651–2664. doi:10.3762/bjoc.14.243

Download Citation

Citation data can be downloaded as file using the "Download" button or used for copy/paste from the text window below.
Citation data in RIS format can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Zotero.

Presentation Graphic

Picture with graphical abstract, title and authors for social media postings and presentations.
Format: PNG Size: 638.7 KB Download

Citations to This Article

Up to 20 of the most recent references are displayed here.

Scholarly Works

  • Mi, J.; Yu, Z.; Yu, H.; Zhou, W. Quorum Sensing systems in foodborne Salmonella spp. and corresponding control strategies using Quorum Sensing inhibitors for food storage. Trends in Food Science & Technology 2024, 144, 104320. doi:10.1016/j.tifs.2023.104320
  • Lamichhane, B.; Mawad, A. M. M.; Saleh, M.; Kelley, W. G.; Harrington, P. J.; Lovestad, C. W.; Amezcua, J.; Sarhan, M. M.; El Zowalaty, M. E.; Ramadan, H.; Morgan, M.; Helmy, Y. A. Salmonellosis: An Overview of Epidemiology, Pathogenesis, and Innovative Approaches to Mitigate the Antimicrobial Resistant Infections. Antibiotics (Basel, Switzerland) 2024, 13, 76. doi:10.3390/antibiotics13010076
  • Parga, A.; Muras, A.; Otero-Casal, P.; Arredondo, A.; Soler-Ollé, A.; Àlvarez, G.; Alcaraz, L. D.; Mira, A.; Blanc, V.; Otero, A. The quorum quenching enzyme Aii20J modifies in vitro periodontal biofilm formation. Frontiers in cellular and infection microbiology 2023, 13, 1118630. doi:10.3389/fcimb.2023.1118630
  • Wang, D.; Cui, F.; Ren, L.; Li, J.; Li, T. Quorum-quenching enzymes: Promising bioresources and their opportunities and challenges as alternative bacteriostatic agents in food industry. Comprehensive reviews in food science and food safety 2023, 22, 1104–1127. doi:10.1111/1541-4337.13104
  • Dicks, L. M. T. How does Quorum Sensing of Intestinal Bacteria Affect Our Health and Mental Status?. Microorganisms 2022, 10, 1969. doi:10.3390/microorganisms10101969
  • Styles, M. J.; Boursier, M. E.; McEwan, M. A.; Santa, E. E.; Mattmann, M. E.; Slinger, B. L.; Blackwell, H. E. Autoinducer-fluorophore conjugates enable FRET in LuxR proteins in vitro and in cells. Nature chemical biology 2022, 18, 1115–1124. doi:10.1038/s41589-022-01089-1
  • Sionov, R. V.; Steinberg, D. Targeting the Holy Triangle of Quorum Sensing, Biofilm Formation, and Antibiotic Resistance in Pathogenic Bacteria. Microorganisms 2022, 10, 1239. doi:10.3390/microorganisms10061239
  • Deng, C.; Wu, Y.; Lv, X.; Li, J.; Liu, Y.; Du, G.; Chen, J.; Liu, L. Refactoring transcription factors for metabolic engineering. Biotechnology advances 2022, 57, 107935. doi:10.1016/j.biotechadv.2022.107935
  • Bremner, J. Future Possibilities. Multiple Action-Based Design Approaches to Antibacterials; Springer Singapore, 2021; pp 159–187. doi:10.1007/978-981-16-0999-2_5
  • Styles, M. J.; Early, S. A.; Tucholski, T.; West, K. H. J.; Ge, Y.; Blackwell, H. E. Chemical Control of Quorum Sensing in E. coli: Identification of Small Molecule Modulators of SdiA and Mechanistic Characterization of a Covalent Inhibitor. ACS infectious diseases 2020, 6, 3092–3103. doi:10.1021/acsinfecdis.0c00654
  • Acharya, D. D.; Miller, I. J.; Cui, Y.; Braun, D. R.; Berres, M. E.; Styles, M. J.; Li, L.; Kwan, J. C.; Rajski, S. R.; Blackwell, H. E.; Bugni, T. S. Omics Technologies to Understand Activation of a Biosynthetic Gene Cluster in Micromonospora sp. WMMB235: Deciphering Keyicin Biosynthesis. ACS chemical biology 2019, 14, 1260–1270. doi:10.1021/acschembio.9b00223
  • Boursier, M. E.; Combs, J. B.; Blackwell, H. E. N-Acyl l-Homocysteine Thiolactones Are Potent and Stable Synthetic Modulators of the RhlR Quorum Sensing Receptor in Pseudomonas aeruginosa. ACS chemical biology 2019, 14, 186–191. doi:10.1021/acschembio.8b01079
  • Yang, Y.; Zhou, M.; Hardwidge, P. R.; Cui, H.; Zhu, G. Isolation and Characterization of N-acyl Homoserine Lactone-Producing Bacteria From Cattle Rumen and Swine Intestines. Frontiers in cellular and infection microbiology 2018, 8, 155. doi:10.3389/fcimb.2018.00155
Other Beilstein-Institut Open Science Activities