Molecular iodine-catalyzed one-pot multicomponent synthesis of 5-amino-4-(arylselanyl)-1H-pyrazoles

  1. Camila S. Pires1,
  2. Daniela H. de Oliveira1,
  3. Maria R. B. Pontel1,
  4. Jean C. Kazmierczak2,
  5. Roberta Cargnelutti2,
  6. Diego Alves1,
  7. Raquel G. Jacob1 and
  8. Ricardo F. Schumacher1,2ORCID Logo

1LASOL - CCQFA - Universidade Federal de Pelotas - UFPel - P.O. Box 354 - 96010-900, Pelotas, RS, Brazil
2Departamento de Química, Universidade Federal de Santa Maria – UFSM, 97105-900, Santa Maria, RS, Brazil

  1. Corresponding author email

Associate Editor: T. J. J. Müller
Beilstein J. Org. Chem. 2018, 14, 2789–2798. doi:10.3762/bjoc.14.256
Received 06 Jul 2018, Accepted 25 Oct 2018, Published 06 Nov 2018

Abstract

A one-pot iodine-catalyzed multicomponent reaction has been developed for the selective preparation of 5-amino-4-(arylselanyl)-1H-pyrazoles from a diverse array of benzoylacetonitriles, arylhydrazines and diaryl diselenides. The reactions were conducted in MeCN as solvent at reflux temperature under air. The methodology presents a large functional group tolerance to electron-deficient, electron-rich, and bulky substituents and gave the expected products in good to excellent yields. The synthesized 1,3-diphenyl-4-(phenylselanyl)-1H-pyrazol-5-amine was submitted to an oxidative dehydrogenative coupling to produce a diazo compound confirmed by X-ray analysis.

Keywords: diaryl diselenide; diazo compound; 1H-pyrazole; molecular iodine; multicomponent reaction

Introduction

Selenium-containing compounds are of great importance in bioactive compounds, pharmaceuticals, and as chemical intermediates for organic and inorganic synthesis [1,2]. As a consequence, the development of efficient and practical methods for C–Se bond formation is still a promising field of research in organic chemistry. Despite the several number of methodologies describing the transition metal-catalyzed cross-coupling reaction of diorganyl diselenides with (hetero)aryl, alkenyl, and alkynyl halides or pseudo-halides [3], an updated protocol that describe reduced waste generation and atom-economy is desired. In this context, the multicomponent cyclization/direct selanylation is a practical and economical way to incorporate organylselanyl moieties in aryl and heteroaryl compounds avoiding the necessity of pre-functionalization, multistep synthesis and tedious work-up [4,5]. In this context, the preparation of diverse selanylated indoles and imidazopyridines, for example, is widely found in literature [6,7]. However, the preparation of 4-arylselanyl-1H-pyrazoles is quite scarce. Tiecco and co-workers described the preparation of phenylseleno substituted pyrazolidines by reacting allylhydrazines with phenylselanenyl sulfate generated in situ (Scheme 1) [8]. Attanasi and co-workers described the synthesis of 4-(phenylseleno)pyrazol-3-ones through α-(phenylseleno)hydrazone reagents under basic conditions [9]. In 2015, Yu and co-workers described one example for the condensation reaction of α-oxo ketene dithioacetal with hydrazine hydrate to produce the 3-methyl-5-methylsulfanyl-4-phenylselanyl-1H-pyrazole [10]. Our research group described the multicomponent synthesis of 3,5-dimethyl-4-arylselanyl-1H-pyrazoles catalyzed by copper iodide using DMSO as solvent [4]. More recently, Zora and co-workers reported the one-pot preparation of 4-phenylselanyl-1H-pyrazoles through reaction of α,β-alkynic hydrazones with phenylselenyl chloride [11].

[1860-5397-14-256-i1]

Scheme 1: Synthesis of selanyl-pyrazoles and their derivatives previously described.

In this context, pyrazoles are one of the most important N-heterocycles found in natural products including formycin, pyrazofurin and withasomnine, for example. Still, pyrazole unities are present in several commercially available drugs such as celecoxib, lonazolac, rimonabant and sildenafil [12,13]. In special, 5-amino-1H-pyrazoles are valuable compounds that present several biological and pharmaceutical activities including antiviral, anticancer, antituberculosis, anti-inflammatory, antifungal and antidepressive activity [14-17]. Moreover, they have been extensively used as synthons to prepare a wide variety of fused N-heterocycles of synthetic and pharmacological importance [18-20]. Thus, an effective strategy for the design and the preparation of new pharmacologically promising drugs that combine at least two bioactive moieties in one molecule avoiding residual metal in transition-metal catalysis in environmental benign conditions is desired. Recently, Sun and co-workers described their interesting results on the I2-catalyzed efficient synthesis of 5-amino-4-sulfanylpyrazoles using diverse β-ketonitriles, arylhydrazines and aryl sulfonyl hydrazides as sulfur source [21]. The chemistry of iodine-catalyzed transformations has emerged as a greener, efficient and economical alternative to transition metals in organic synthesis [22-24]. However, the synthesis of selenium-containing 5-aminopyrazoles under iodine-catalyzed three-component reaction was not described so far.

In view of this, we present a direct and selective multicomponent strategy to synthesize 5-amino-4-(arylselanyl)-1H-pyrazoles 4 by reacting benzoylacetonitrile derivatives 1, arylhydrazines 2 and diorganyl diselenides 3 (Scheme 2). The reaction is catalysed by molecular iodine in MeCN as solvent.

[1860-5397-14-256-i2]

Scheme 2: Multicomponent reaction proposed in this work.

Results and Discussion

Initially, to optimize the reaction conditions experiments were performed using benzoylacetonitrile (1a), phenylhydrazine (2a) and diphenyl diselenide (3a) as standard substrates to define the best reaction conditions. During the experiments different parameters were evaluated such as temperature, reaction time, solvent, reagent amount and heating method (conventional heating or ultrasound, Table 1).

In a first experiment, benzoylacetonitrile (1a, 0.5 mmol), phenylhydrazine (2a, 0.5 mmol) and diphenyl diselenide (3a, 0.5 mmol) were solubilized in MeCN (3 mL) and molecular iodine (50 mol %) was added. The mixture was stirred at reflux temperature and after 48 h under these conditions, the expected product 4a was obtained in 71% yield (Table 1, entry 1). With these result, we attempted to investigate the parameters regarding quantities (Table 1, entries 2 and 3). Based on it, we observed that the use of a minimum amount of diphenyl diselenide (3a) caused a decrease in the reaction yield, giving the product 4a in 54% (Table 1, entry 2). However, when the reaction was performed using a slight excess of 2a (0.7 mmol) and 3a (0.5 mmol) the reaction yield increased significantly to 96% (Table 1, entry 3). The treatment of 1a, 2a and 3a in the presence of 25, 50 and 75 mol % of molecular iodine afforded the expected product 4a in 68, 96 and 75% yield, respectively (Table 1, entries 3–5). In this sense, better results were obtained when using 50 mol % of I2.

In the next step, the reaction was performed in different solvents such as toluene, 1,4-dioxane and dimethylformamide, but a considerable decrease in the yield of 4a was observed (Table 1, entries 6–8). Similarly, when the reaction was conducted at a lower temperature (Table 1, entry 9) or in a shorter reaction time (Table 1, entry 10), the product 4a was isolated in a poorer yield. The use of ultrasonic irradiation was also tested due to the high-energy transference in the reaction during the cavitation process. Unfortunately, under this condition a low reaction yield of 42% was obtained even after 2 h of reaction (Table 1, entry 11).

Table 1: Optimization of the reaction conditions.a

[Graphic 1]
entry 2a (mmol) 3a (mmol) I2 (mol %) solvent temp. (°C) time (h) yield (%)b
1 0.5 0.5 50 MeCN reflux 48 71
2 0.5 0.25 50 MeCN reflux 48 54
3 0.7 0.5 50 MeCN reflux 48 96
4 0.7 0.5 25 MeCN reflux 48 68
5 0.7 0.5 75 MeCN reflux 48 75
6 0.7 0.5 50 toluene 80 48
7 0.7 0.5 50 DMF 80 48 16
8 0.7 0.5 50 1,4-dioxane 80 48 55
9 0.7 0.5 50 MeCN 60 48 12
10 0.7 0.5 50 MeCN reflux 36 68
11c 0.7 0.5 50 MeCN ))) 2 47

aReaction was performed using 1a (0.5 mmol), 2a and 3a in 3 mL of solvent followed by the addition of molecular iodine. The consumption of starting materials was followed by TLC. bYields are given for isolated products. cThe reaction was carried under ultrasound conditions operating at amplitude of 60% and a frequency of 20 kHz.

With the establishment of the best reaction conditions for the synthesis of 4a described in Table 1, entry 3, we envisaged extending this methodology to diverse benzoylacetonitriles 1af, arylhydrazines 2af and differently substituted diaryl diselenides 3af. In general, as shown in Table 2, most of the reactions proceeded smoothly and provided the desired products in moderate to excellent yields (see Supporting Information File 1 for full experimental data).

Table 2: Substrate scope for the synthesis of 5-amino-4-(arylselanyl)-1H-pyrazoles 4.a

[Graphic 2]
entry ketonitrile 1 aryl hydrazine 2 diaryl diselenide 3 product 4 (yield)b
1 [Graphic 3]
1a
[Graphic 4]
2a
[Graphic 5]
3a
[Graphic 6]
4a (96%)
2 [Graphic 7]
1b
[Graphic 8]
2a
[Graphic 9]
3a
[Graphic 10]
4b (73%)
3 [Graphic 11]
1c
[Graphic 12]
2a
[Graphic 13]
3a
[Graphic 14]
4c (35%)
4 [Graphic 15]
1d
[Graphic 16]
2a
[Graphic 17]
3a
[Graphic 18]
4d (78%)
5 [Graphic 19]
1e
[Graphic 20]
2a
[Graphic 21]
3a
[Graphic 22]
4e (81%)
6 [Graphic 23]
1f
[Graphic 24]
2a
[Graphic 25]
3a
[Graphic 26]
4f (62%)c
7 [Graphic 27]
1a
[Graphic 28]
2b
[Graphic 29]
3a
[Graphic 30]
4g (63%)
8 [Graphic 31]
1a
[Graphic 32]
2c
[Graphic 33]
3a
[Graphic 34]
4h (52%)
9 [Graphic 35]
1a
[Graphic 36]
2d
[Graphic 37]
3a
[Graphic 38]
4i (80%)
10 [Graphic 39]
1a
[Graphic 40]
2e
[Graphic 41]
3a
[Graphic 42]
4j (76%)
11 [Graphic 43]
1a
[Graphic 44]
2f
[Graphic 45]
3a
[Graphic 46]
4k (–)d
12 [Graphic 47]
1a
[Graphic 48]
2a
[Graphic 49]
3b
[Graphic 50]
4l (54%)
13 [Graphic 51]
1a
[Graphic 52]
2a
[Graphic 53]
3c
[Graphic 54]
4m (63%)
14 [Graphic 55]
1a
[Graphic 56]
2a
[Graphic 57]
3d
[Graphic 58]
4n (80%)
15 [Graphic 59]
1a
[Graphic 60]
2c
[Graphic 61]
3e
[Graphic 62]
4o (24%)
16 [Graphic 63]
1a
[Graphic 64]
2c
[Graphic 65]
3f
[Graphic 66]
4p (–)d

aReactions were performed by using 1 (0.5 mmol), 2 (0.7 mmol), 3 (0.5 mmol) and I2 (50 mol %) in MeCN (3 mL) at reflux temperature for 48 h in air. bYield is given for isolated products. cYield is given for a mixture of 5-amino-4-(phenylselanyl)pyrazole and 5-aminopyrazole (1:2) determined by 1H NMR. dProduct not obtained.

The substrate scope of this reaction was investigated under the optimized reaction conditions. Initially, to achieve this goal, we carried out a reaction of phenylhydrazine (2a) and diphenyl diselenide (3a) with benzoylacetonitrile 1b containing an electron-donating group on the aromatic ring, that provided the corresponding product 4b gently in 73% yield. When we performed the reaction by using the benzoylacetonitrile derivative 1c substituted with a methoxy group, a lower isolated yield was observed (Table 2, entry 3). This may be associated with the high reactivity of 1c which produced many byproducts as observed by TLC and GC–MS analysis. Benzoylacetonitriles 1d,e substituted with electron-withdrawing groups such as Br and Cl were also tested and afforded the corresponding products 4d and 4e in good yields (Table 2, entries 4 and 5). However, when we used an ortho-chloro substituted benzoylacetonitrile 1f, the corresponding product 4f was isolated as a non-separable mixture with the non-selenylated 5-aminopyrazole (Table 2, entry 6).

Next we evaluated the reactivity of different functionalized arylhydrazines 2af using benzoylacetonitrile 1a and diphenyl diselenide 3a as standard reagents (Table 2, entries 7–11). Substituted arylhydrazines were sensitive to the electronic effect of the groups directly bonded to aromatic ring. In this sense, arylhydrazines 2b and 2c containing EDG at the aromatic ring gave lower yields than arylhydrazines 2d and 2e containing EWG (Table 2, entries 7 and 8 vs 9 and 10). On the other hand, when 2,4-dinitrophenylhydrazine was used, the expected pyrazole 4k was not detected by GC–MS analysis. (Table 2, entry 11).

In addition, different diaryl diselenides 3be were studied to produce valuable 5-amino-4-(arylselanyl)-1H-pyrazoles 4lo (Table 2, entries 12–15). In this case, it is possible to see that all diaryl diselenides were efficiently coupled to 5-amino-1H-pyrazole to produce the corresponding products in yields ranging from 24% to 80%. However, when the bulkier 1,2-dimesityl diselenide 3f was employed, no product was obtained (Table 2, entry 16).

To gain insight into the mechanistic profile we also evaluated whether 5-amino-1H-pyrazole 5a could produce 5-amino-4-(phenylselanyl)-1H-pyrazole 4a via direct C–H bond selanylation reaction catalyzed by iodine. Thus, when 5a reacted with diphenyl diselenide (3a) in the presence of 50 mol % of I2 in acetonitrile as solvent and under reflux, the desired product 4a could be obtained in 90% yield as depicted in Scheme 3.

[1860-5397-14-256-i3]

Scheme 3: Direct selanylation reaction of 5-amino-pyrazole 5a with diphenyl diselenide (3a) under the optimized conditions.

On the basis of previous reports [21,25] a mechanism can be proposed for this reaction as depicted in Scheme 4. Initially, we believe that arylhydrazine 2 reacts with benzoylacetonitrile 1 by a 1,2-addition reaction in the presence of iodine as Lewis acid to generate the hydrazone intermediate A. Then, hydrazone A undergoes a cyclization reaction followed by an oxidative aromatization to yield 1H-pyrazol-5-amine 5. At the same time, the diaryl diselenide 3 reacts with the molecular iodine to generate an electrophilic selenium species B. The following step is the nucleophilic attack of the electron-rich pyrazole 5 to species B to afford product 4 after releases a proton and produce HI. The presence of oxygen into the reaction system is expected to regenerate the iodine to continue the catalytic cycle.

[1860-5397-14-256-i4]

Scheme 4: Proposed reaction mechanism.

To verify the synthetic application of 5-amino-4-(arylselanyl)-1H-pirazoles 4, we selected compound 4a to prepare a new diazopyrazole derivative 6 based on the methodology described by Jiang and co-workers [26]. In this context, by reacting the 4-(phenylselanyl)pyrazol-5-amine 4a with CuI (5 mol %), 1,10-phenantroline (15 mol %) and tert-butyl hydroperoxide in dichloromethane at room temperature for 2 h, the respective diazo aromatic compound 6 could be obtained in 50% yield (Scheme 5). As can be seen, the reaction proceeded smoothly allowing formation of the new N=N bond without cleavage of the C–Se bond under the oxidant media and the presence of copper salt.

[1860-5397-14-256-i5]

Scheme 5: Synthesis of diazo pyrazole derivative 6.

To confirm the structure of 6, its molecular structure was also analyzed by single-crystal X-ray diffraction (CCDC: 1853770). The molecular structure is demonstrated in Figure 1.

[1860-5397-14-256-1]

Figure 1: Molecular structure of compound 6. The hydrogen atoms are omitted for clarity [27].

Conclusion

A variety of 4-(arylselanyl)-1H-pyrazol-5-amines was prepared in a one-pot multicomponent procedure starting from easily available benzoylacetonitriles, arylhydrazines and diaryl diselenides. Molecular iodine (50 mol %) was employed to promote this reaction in MeCN under reflux temperature and afforded the expected products in a range of 24% to 96% yield after 48 hours. Finally, the obtained 4-(phenylselanyl)-1H-pyrazol-5-amine proved to be a promising starting material for synthesizing new diazo compounds with higher added value. The protocol described here can be considered a valuable tool for the advance of the synthesis and pharmacological studies of selenium-containing pyrazoles and derivatives.

Supporting Information

The Supporting Information features full experimental data and copies of 1H and 13C NMR spectra of pyrazoles 4 and 6.

Supporting Information File 1: Experimental part.
Format: PDF Size: 1.8 MB Download

Acknowledgements

The authors thank FAPERGS (ARD 16/2551-0000358-0 and PRONEM 16/2551-0000240-1), CNPq, CAPES and FINEP for the financial support. CNPq is also acknowledged for the fellowship for R.G.J. and D.A.

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