Mechanochemistry of nucleosides, nucleotides and related materials

Scholarly Works

• Yamamoto, T.; Kubota, K.; Harabuchi, Y.; Ito, H. Scaling theory for the kinetics of mechanochemical reactions with convective flow. RSC Mechanochemistry 2025, 2, 230–239. doi:10.1039/d4mr00091a
• Kubota, K.; Makino, T.; Kondo, K.; Seo, T.; Jin, M.; Ito, H. Solid-state aromatic nucleophilic fluorination: a rapid, practical, and environmentally friendly route to N-heteroaryl fluorides. Green Chemistry 2025, 27, 1771–1776. doi:10.1039/d4gc06362g
• Kudalkar, M. V.; Patel, M. A.; Sanghvi, Y. S.; Kapdi, A. R. Achieving Sustainability in the Assembly of Modified Nucleosides Using Green Solvents. Sustainability & Circularity NOW 2024, 2. doi:10.1055/a-2479-0995
• Kubota, K.; Kawamura, S.; Jiang, J.; Maeda, S.; Ito, H. Mechanochemical generation of aryl barium nucleophiles from unactivated barium metal. Chemical science 2024, 15, 17453–17459. doi:10.1039/d4sc05361c
• Kubota, K.; Hisazumi, R.; Seo, T.; Ito, H. Mechanochemistry enabled highly efficient solvent-free deoxygenation of phosphine oxides in air. RSC Mechanochemistry 2024, 1, 250–254. doi:10.1039/d4mr00011k
• Seo, T. Dual Nickel(II)/Mechanoredox Catalysis: Mechanical-Force-Driven Aryl-Amination Reactions Using Ball Milling and Piezoelectric Materials. Springer Theses; Springer Nature Singapore, 2024; pp 243–278. doi:10.1007/978-981-97-1991-4_8
• Seo, T. Mechanochemistry-Directed Ligand Design: Development of a High-Performance Phosphine Ligand for Palladium-Catalyzed Mechanochemical Organoboron Cross-Coupling. Springer Theses; Springer Nature Singapore, 2024; pp 161–210. doi:10.1007/978-981-97-1991-4_6
• Seo, T. Tackling Solubility Issues in Organic Synthesis: Solid-State Cross-Coupling of Insoluble Aryl Halides. Springer Theses; Springer Nature Singapore, 2024; pp 93–142. doi:10.1007/978-981-97-1991-4_4
• Yamamoto, T.; Kubota, K.; Ito, H. Dissolution-Limited Reactions in Solid-State Synthesis. Nihon Reoroji Gakkaishi 2024, 52, 161–170. doi:10.1678/rheology.52.161
• Kondo, K.; Kubota, K.; Ito, H. Mechanochemistry enabling highly efficient Birch reduction using sodium lumps and d-(+)-glucose. Chemical science 2024, 15, 4452–4457. doi:10.1039/d3sc06052g
• Navarro, V.; Vasco, F.; Bantreil, X.; Lamaty, F.; Peyrottes, S.; Roy, B. Ball‐Milling to Access Dinucleoside Polyphosphates and Analogues. Advanced Synthesis & Catalysis 2024, 366, 1776–1781. doi:10.1002/adsc.202400057
• Seo, T.; Kubota, K.; Ito, H. Dual Nickel(II)/Mechanoredox Catalysis: Mechanical‐Force‐Driven Aryl‐Amination Reactions Using Ball Milling and Piezoelectric Materials. Angewandte Chemie 2023, 135. doi:10.1002/ange.202311531
• Seo, T.; Kubota, K.; Ito, H. Dual Nickel(II)/Mechanoredox Catalysis: Mechanical-Force-Driven Aryl-Amination Reactions Using Ball Milling and Piezoelectric Materials. Angewandte Chemie (International ed. in English) 2023, 62, e202311531. doi:10.1002/anie.202311531
• Kubota, K. Exploring Novel Synthetic Concepts and Strategies Using Mechanochemistry. Bulletin of the Chemical Society of Japan 2023, 96, 913–930. doi:10.1246/bcsj.20230157
• Seo, T.; Kubota, K.; Ito, H. Mechanochemistry-Directed Ligand Design: Development of a High-Performance Phosphine Ligand for Palladium-Catalyzed Mechanochemical Organoboron Cross-Coupling. Journal of the American Chemical Society 2023, 145, 6823–6837. doi:10.1021/jacs.2c13543
• Mallah, D.; Mirjalili, B. B. F. A green protocol ball milling synthesis of dihydropyrano[2,3-c]pyrazole using nano-silica/aminoethylpiperazine as a metal-free catalyst. BMC chemistry 2023, 17, 10. doi:10.1186/s13065-023-00934-1
• Priestley, I.; Battilocchio, C.; Iosub, A. V.; Barreteau, F.; Bluck, G. W.; Ling, K. B.; Ingram, K.; Ciaccia, M.; Leitch, J. A.; Browne, D. L. Safety Considerations and Proposed Workflow for Laboratory-Scale Chemical Synthesis by Ball Milling. Organic Process Research & Development 2023, 27, 269–275. doi:10.1021/acs.oprd.2c00226
• Isshiki, R.; Kubota, K.; Ito, H. Solid-State Silver-Catalyzed Ring-Opening Fluorination of Cyclobutanols by Using Mechanochemistry. Synlett 2023, 34, 1419–1424. doi:10.1055/a-2021-9599
• Takahashi, R.; Gao, P.; Kubota, K.; Ito, H. Mechanochemical protocol facilitates the generation of arylmanganese nucleophiles from unactivated manganese metal. Chemical science 2023, 14, 499–505. doi:10.1039/d2sc05468j
• Miller, S.; Moos, W.; Munk, B.; Munk, S.; Hart, C.; Spellmeyer, D. Chemical development: Synthetic studies and engineering including aspects of batch production and continuous processing. Managing the Drug Discovery Process; Elsevier, 2023; pp 539–551. doi:10.1016/b978-0-12-824304-6.00018-3

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