A review of the total syntheses of triptolide

Xiang Zhang, Zaozao Xiao and Hongtao Xu
Beilstein J. Org. Chem. 2019, 15, 1984–1995. https://doi.org/10.3762/bjoc.15.194

Cite the Following Article

A review of the total syntheses of triptolide
Xiang Zhang, Zaozao Xiao and Hongtao Xu
Beilstein J. Org. Chem. 2019, 15, 1984–1995. https://doi.org/10.3762/bjoc.15.194

How to Cite

Zhang, X.; Xiao, Z.; Xu, H. Beilstein J. Org. Chem. 2019, 15, 1984–1995. doi:10.3762/bjoc.15.194

Download Citation

Citation data can be downloaded as file using the "Download" button or used for copy/paste from the text window below.
Citation data in RIS format can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Zotero.

Presentation Graphic

Picture with graphical abstract, title and authors for social media postings and presentations.
Format: PNG Size: 87.3 KB Download

Citations to This Article

Up to 20 of the most recent references are displayed here.

Scholarly Works

  • Fukuyama, Y.; Kubo, M.; Harada, K. Neurotrophic Natural Products. Progress in the chemistry of organic natural products 2024, 123, 1–473. doi:10.1007/978-3-031-42422-9_1
  • Xiao, Z.; Gu, Y.; Dong, H.; Liu, B.; Jin, W.; Li, J.; Ma, P.; Xu, H.; Hou, W. Strategic application of CuAAC click chemistry in the modification of natural products for anticancer activity. European Journal of Medicinal Chemistry Reports 2023, 9, 100113. doi:10.1016/j.ejmcr.2023.100113
  • Zhang, Y.; Gao, J.; Ma, L.; Tu, L.; Hu, T.; Wu, X.; Su, P.; Zhao, Y.; Liu, Y.; Li, D.; Zhou, J.; Yin, Y.; Tong, Y.; Zhao, H.; Lu, Y.; Wang, J.; Gao, W.; Huang, L. Tandemly duplicated CYP82Ds catalyze 14-hydroxylation in triptolide biosynthesis and precursor production in Saccharomyces cerevisiae. Nature communications 2023, 14, 875. doi:10.1038/s41467-023-36353-y
  • Belen'kii, L. I.; Gazieva, G. A.; Evdokimenkova, Y. B.; Soboleva, N. O. The literature of heterocyclic chemistry, Part XIX, 2019. Advances in Heterocyclic Chemistry; Elsevier, 2022; pp 225–295. doi:10.1016/bs.aihch.2021.09.002
  • Zhang, X.; Zhang, S.; Zhao, S.; Wang, X.; Liu, B.; Xu, H. Click Chemistry in Natural Product Modification. Frontiers in chemistry 2021, 9, 774977. doi:10.3389/fchem.2021.774977
  • Cheng, Y.; Zhao, Y.; Zheng, Y. Therapeutic potential of triptolide in autoimmune diseases and strategies to reduce its toxicity. Chinese medicine 2021, 16, 114. doi:10.1186/s13020-021-00525-z
  • Liang, D.; Mai, H.; Ruan, F.; Fu, H. The Efficacy of Triptolide in Preventing Diabetic Kidney Diseases: A Systematic Review and Meta-Analysis. Frontiers in pharmacology 2021, 12, 728758. doi:10.3389/fphar.2021.728758
  • Gao, J.; Zhang, Y.; Liu, X.; Wu, X.; Huang, L.; Gao, W. Triptolide: pharmacological spectrum, biosynthesis, chemical synthesis and derivatives. Theranostics 2021, 11, 7199–7221. doi:10.7150/thno.57745
  • Hu, Z.; Liu, X.; Tian, M.; Ma, Y.; Jin, B.; Gao, W.; Cui, G.; Guo, J.; Huang, L. Recent progress and new perspectives for diterpenoid biosynthesis in medicinal plants. Medicinal research reviews 2021, 41, 2971–2997. doi:10.1002/med.21816
  • Tong, L.; Zhao, Q.; Datan, E.; Lin, G. Q.; Minn, I.; Pomper, M. G.; Yu, B.; Romo, D.; He, Q.-L.; Liu, J. O. Triptolide: reflections on two decades of research and prospects for the future. Natural product reports 2021, 38, 843–860. doi:10.1039/d0np00054j
  • Hu, C.; Li, H.; Wu, L.; Ke, J.; Yu, X.; Xiong, Y.; Tang, X. Metabolic profiling of 19 amino acids in triptolide-induced liver injured rats by gas chromatography-triple quadrupole mass spectrometry. Human & experimental toxicology 2021, 40, 9603271211006167. doi:10.1177/09603271211006167
  • Miao, G.-p.; Han, J.; Huo, Y.-B.; Wang, C.-r.; Wang, S.-c. Identification and functional characterization of a PDR transporter in Tripterygium wilfordii Hook.f. that mediates the efflux of triptolide. Plant molecular biology 2021, 106, 145–156. doi:10.1007/s11103-021-01134-y
  • Ren, Y.; Kinghorn, A. D. Development of Potential Antitumor Agents from the Scaffolds of Plant-Derived Terpenoid Lactones. Journal of medicinal chemistry 2020, 63, 15410–15448. doi:10.1021/acs.jmedchem.0c01449
  • Silverberg, L. J. The Pandemic Defeated My CURE: Replacement with a Student Project of a Literature Review of the Syntheses of Small Molecule Drugs. Journal of Chemical Education 2020, 97, 3450–3454. doi:10.1021/acs.jchemed.0c00555
  • Zhang, H.; Lu, G. Synthesis of celastrol derivatives as potential non-nucleoside hepatitis B virus inhibitors. Chemical biology & drug design 2020, 96, 1380–1386. doi:10.1111/cbdd.13746
Other Beilstein-Institut Open Science Activities