Azologization and repurposing of a hetero-stilbene-based kinase inhibitor: towards the design of photoswitchable sirtuin inhibitors

Christoph W. Grathwol, Nathalie Wössner, Sören Swyter, Adam C. Smith, Enrico Tapavicza, Robert K. Hofstetter, Anja Bodtke, Manfred Jung and Andreas Link

Beilstein J. Org. Chem. 2019, 15, 2170–2183. https://doi.org/10.3762/bjoc.15.214

Supporting Information

The Supporting Information features experimental and analytical data for the synthesis of intermediates and compounds 4a, 4b, 2c–2h and 8a and 1H and 13C NMR spectra for all synthesized compounds. Procedures of photochemical experiments and their analysis are described. Detailed summaries of electronic structure calculations for two conformers (A and B) of each double bond isomer ((E)-2b and (Z)-2b), photocyclization and oxidation products 8a and 8b are given.

Supporting Information File 1: Experimental procedures, analytical data and quantum chemical calulations.
Format: PDF Size: 7.8 MB Download

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