Current understanding and biotechnological application of the bacterial diterpene synthase CotB2

Scholarly Works

• Alsup, T. A.; Opoku, M. O.; Rudolf, J. D. Characterization of UbiA terpene synthases with a precursor overproduction system in Escherichia coli. Methods in Enzymology; Elsevier, 2024. doi:10.1016/bs.mie.2024.02.001
• Spencer, T. A.; Ditchfield, R. Tryptophan Stabilization of a Biochemical Carbocation Evaluated by Analysis of π Complexes of 3-Ethylindole with the t-Butyl Cation. ACS omega 2023, 8, 26497–26507. doi:10.1021/acsomega.3c03259
• Tarasova, E. V.; Luchnikova, N. A.; Grishko, V. V.; Ivshina, I. B. Actinomycetes as Producers of Biologically Active Terpenoids: Current Trends and Patents. Pharmaceuticals (Basel, Switzerland) 2023, 16, 872. doi:10.3390/ph16060872
• Li, Z.; Rudolf, J. D. Biosynthesis, enzymology, and future of eunicellane diterpenoids. Journal of industrial microbiology & biotechnology 2023, 50. doi:10.1093/jimb/kuad027
• Xu, B.; Ning, W.; Wei, X.; Rudolf, J. D. Mutation of the eunicellane synthase Bnd4 alters its product profile and expands its prenylation ability. Organic & biomolecular chemistry 2022, 20, 8833–8837. doi:10.1039/d2ob01931k
• Gong, K.; Yong, D.; Fu, J.; Li, A.; Zhang, Y.; Li, R. Diterpenoids from Streptomyces: Structures, Biosyntheses and Bioactivities. Chembiochem : a European journal of chemical biology 2022, 23, e202200231. doi:10.1002/cbic.202200231
• Ringel, M.; Dimos, N.; Himpich, S.; Haack, M.; Huber, C.; Eisenreich, W.; Schenk, G.; Loll, B.; Brück, T. Biotechnological potential and initial characterization of two novel sesquiterpene synthases from Basidiomycota Coniophora puteana for heterologous production of δ-cadinol. Microbial cell factories 2022, 21, 64. doi:10.1186/s12934-022-01791-8
• Huang, Z.-Y.; Ye, R.-Y.; Yu, H.-L.; Li, A.; Xu, J.-H. Mining methods and typical structural mechanisms of terpene cyclases. Bioresources and Bioprocessing 2021, 8, 1–27. doi:10.1186/s40643-021-00421-2
• Zhu, C.; Xu, B.; Adpressa, D. A.; Rudolf, J. D.; Loesgen, S. Discovery and Biosynthesis of a Structurally Dynamic Antibacterial Diterpenoid. Angewandte Chemie (International ed. in English) 2021, 60, 14163–14170. doi:10.1002/anie.202102453
• Zhu, C.; Xu, B.; Adpressa, D. A.; Rudolf, J. D.; Loesgen, S. Entdeckung und Biosynthese eines strukturdynamischen antibakteriellen Diterpenoids. Angewandte Chemie 2021, 133, 14282–14289. doi:10.1002/ange.202102453
• Xu, B.; Li, Z.; Alsup, T. A.; Ehrenberger, M. A.; Rudolf, J. D. Bacterial diterpene synthases prenylate small molecules. ACS catalysis 2021, 11, 5906–5915. doi:10.1021/acscatal.1c01113
• Raz, K.; Driller, R.; Dimos, N.; Ringel, M.; Brück, T.; Loll, B.; Major, D. T. The Impression of a Nonexisting Catalytic Effect: The Role of CotB2 in Guiding the Complex Biosynthesis of Cyclooctat-9-en-7-ol. Journal of the American Chemical Society 2020, 142, 21562–21574. doi:10.1021/jacs.0c11348
• Tang, X.; Zhang, F.; Zeng, T.; Li, W.; Yin, S.; Wu, R. Enzymatic Plasticity Inspired by the Diterpene Cyclase CotB2. ACS chemical biology 2020, 15, 2820–2832. doi:10.1021/acschembio.0c00645
• Ringel, M.; Reinbold, M.; Hirte, M.; Haack, M.; Huber, C.; Eisenreich, W.; Masri, M.; Schenk, G.; Guddat, L. W.; Loll, B.; Kerr, R. G.; Garbe, D.; Brück, T. Towards a sustainable generation of pseudopterosin-type bioactives. Green Chemistry 2020, 22, 6033–6046. doi:10.1039/d0gc01697g
• Raz, K.; Levi, S.; Gupta, P. K.; Major, D. T. Enzymatic control of product distribution in terpene synthases: insights from multiscale simulations. Current opinion in biotechnology 2020, 65, 248–258. doi:10.1016/j.copbio.2020.06.002
• Liu, Y.; Duan, A.; Chen, L.; Wang, D.; Xie, Q.; Xiang, B.; Lin, Y.; Hao, X.; Zhu, X. A Fungal Diterpene Synthase Is Responsible for Sterol Biosynthesis for Growth. Frontiers in microbiology 2020, 11, 1426. doi:10.3389/fmicb.2020.01426

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