Cite the Following Article
Safe and highly efficient adaptation of potentially explosive azide chemistry involved in the synthesis of Tamiflu using continuous-flow technology
Cloudius R. Sagandira and Paul Watts
Beilstein J. Org. Chem. 2019, 15, 2577–2589.
https://doi.org/10.3762/bjoc.15.251
How to Cite
Sagandira, C. R.; Watts, P. Beilstein J. Org. Chem. 2019, 15, 2577–2589. doi:10.3762/bjoc.15.251
Download Citation
Citation data can be downloaded as file using the "Download" button or used for copy/paste from the text window
below.
Citation data in RIS format can be imported by all major citation management software, including EndNote,
ProCite, RefWorks, and Zotero.
Presentation Graphic
| Picture with graphical abstract, title and authors for social media postings and presentations. | ||
| Format: PNG | Size: 130.4 KB | Download |
Citations to This Article
Up to 20 of the most recent references are displayed here.
Scholarly Works
- Lyall-Brookes, G.; Padgham, A. C.; Slater, A. G. Flow chemistry as a tool for high throughput experimentation. Digital Discovery 2025, 4, 2364–2400. doi:10.1039/d5dd00129c
- Koeberg, B. L.; Sagandira, M. B.; Sagandira, C. R.; Watts, P. Paradigm shift in medicinal products synthesis: Continuous flow technology. Tetrahedron 2024, 168, 134333. doi:10.1016/j.tet.2024.134333
- Majhi, S.; Manickam, S. Adaptation of organic reactions in the industrial production of bioactive compounds. Semisynthesis of Bioactive Compounds and their Biological Activities; Elsevier, 2024; pp 353–380. doi:10.1016/b978-0-443-15269-6.00002-x
- Sagmeister, P.; Prieschl, M.; Kaldre, D.; Gadiyar, C.; Moessner, C.; Sedelmeier, J.; Williams, J. D.; Kappe, C. O. Continuous Flow-Facilitated CB2 Agonist Synthesis, Part 1: Azidation and [3 + 2] Cycloaddition. Organic Process Research & Development 2023, 27, 592–600. doi:10.1021/acs.oprd.3c00035
- Pandey, A. M.; Mondal, S.; Gnanaprakasam, B. Continuous-Flow Direct Azidation of Alcohols and Peroxides for the Synthesis of Quinoxalinone, Benzooxazinone, and Triazole Derivatives. The Journal of organic chemistry 2022, 87, 9926–9939. doi:10.1021/acs.joc.2c00941
- Taggert, B. I.; Walker, C.; Chen, D.; Wille, U. Substituted 1,2,3-triazoles: a new class of nitrification inhibitors. Scientific reports 2021, 11, 1–12. doi:10.1038/s41598-021-94306-1
- Guyo, U.; Hlangothi, B. G.; Zeelie, B. Synthesis of novel methoxyether derivative of isopulegol in a packed-bed flow reactor. Monatshefte für Chemie - Chemical Monthly 2021, 152, 695–704. doi:10.1007/s00706-021-02778-8
- Sagandira, C. R.; Watts, P. Flow Chemistry Supporting Access to Drugs in Developing Countries. Topics in Medicinal Chemistry; Springer International Publishing, 2021; pp 391–419. doi:10.1007/7355_2021_114
- Sagandira, C. R.; Watts, P.
- Díaz-Ortiz, Á.; de la Hoz, A. Green Aspects of Flow Chemistry for Drug Discovery. Topics in Medicinal Chemistry; Springer International Publishing, 2021; pp 23–70. doi:10.1007/7355_2021_111
- Díaz-Ortiz, A.; de la Hoz, A.
- Puglisi, A.; Rossi, S.; Herbrik, F.; Medici, F.; Benaglia, M. In-flow enantioselective homogeneous organic synthesis. Green Processing and Synthesis 2021, 10, 768–778. doi:10.1515/gps-2021-0073
- Hayashi, Y. Time Economy in Total Synthesis. The Journal of organic chemistry 2020, 86, 1–23. doi:10.1021/acs.joc.0c01581
- Sagandira, C. R.; Siyawamwaya, M.; Watts, P. 3D printing and continuous flow chemistry technology to advance pharmaceutical manufacturing in developing countries. Arabian journal of chemistry 2020, 13, 7886–7908. doi:10.1016/j.arabjc.2020.09.020
- Fülöp, Z.; Szemesi, P.; Bana, P.; Éles, J.; Greiner, I. Evolution of flow-oriented design strategies in the continuous preparation of pharmaceuticals. Reaction Chemistry & Engineering 2020, 5, 1527–1555. doi:10.1039/d0re00273a
- Sagandira, C. R.; Mathe, F. M.; Guyo, U.; Watts, P. The evolution of Tamiflu synthesis, 20 years on: Advent of enabling technologies the last piece of the puzzle?. Tetrahedron 2020, 76, 131440. doi:10.1016/j.tet.2020.131440
- Morodo, R.; Bianchi, P.; Monbaliu, J.-C. Continuous Flow Organophosphorus Chemistry. European Journal of Organic Chemistry 2020, 2020, 5236–5277. doi:10.1002/ejoc.202000430
- Hai, T. A. P.; De Backer, L. J.; Cosford, N. D. P.; Burkart, M. D. Preparation of Mono- and Diisocyanates in Flow from Renewable Carboxylic Acids. Organic Process Research & Development 2020, 24, 2342–2346. doi:10.1021/acs.oprd.0c00167
- Sagandira, C. R.; Watts, P. Continuous-Flow Synthesis of (–)-Oseltamivir Phosphate (Tamiflu). Synlett 2020, 31, 1925–1929. doi:10.1055/s-0039-1690878
- Mata, A.; Weigl, U.; Flögel, O.; Baur, P.; Hone, C. A.; Kappe, C. O. Acyl azide generation and amide bond formation in continuous-flow for the synthesis of peptides. Reaction Chemistry & Engineering 2020, 5, 645–650. doi:10.1039/d0re00034e
Patents
- GNANAPRAKASAM BOOPATHY; PANDEY AKANKSHA M; MONDAL SHANKHAJIT. KONTINUIERLICHER FLIESSPROZESS ZUR SYNTHESE VON ORGANISCHEN AZIDEN. DE 112023002540 T5, March 20, 2025.