A review of asymmetric synthetic organic electrochemistry and electrocatalysis: concepts, applications, recent developments and future directions

Scholarly Works

• Boos, P.; Pandit, N. K.; Dana, S.; von Münchow, T.; Hashidoko, A.; Haberstock, L.; Herbst‐Irmer, R.; Stalke, D.; Ackermann, L. Multiple Atropo Selectivity by κ2‐N,O‐Oxazoline Urea Ligands in Cobaltaelectro‐Catalyzed C─H Activations: Decoding Selectivity with Data Science Integration. ChemistryEurope 2025. doi:10.1002/ceur.202500071
• Zhang, J.; Liu, M.; Zhang, W.; Guo, C. Enantioselective electrochemical nickel-catalyzed vinylogous radical reactions. Science advances 2025, 11, eadu5594. doi:10.1126/sciadv.adu5594
• von Münchow, T.; Pandit, N. K.; Dana, S.; Boos, P.; Peters, S. E.; Boucat, J.; Liu, Y.-R.; Scheremetjew, A.; Ackermann, L. Enantioselective C–H annulations enabled by either nickel- or cobalt-electrocatalysed C–H activation for catalyst-controlled chemodivergence. Nature Catalysis 2025, 8, 257–269. doi:10.1038/s41929-025-01306-9
• Panja, S.; Pan, A.; Biswas, S.; Das, C.; Guha, A.; Nimje, R. Y.; Murali Dhar, T. G.; Gupta, A.; Mathur, A.; Dutta, A.; Roy, L.; Maiti, D. Pallada‐Electrocatalysis Enables Distal Regioselective and Atroposelective Olefination Reactions. Angewandte Chemie 2025. doi:10.1002/ange.202422876
• Qi, Y.; Tuo, Y.; Zhu, Y.; Wei, W.; Wang, M.; Zhao, Y.; Chen, D.; Feng, X. Advances in catalyst design for electrocatalytic epoxidation of olefins. Chemical Engineering Science 2025, 306, 121273. doi:10.1016/j.ces.2025.121273
• Wang, Q.; Wang, X.; Liu, Y.; Zhang, J.; Song, J.; Guo, C. Enantioselective Multicomponent Electrochemical Difunctionalization of Terminal Alkynes. Journal of the American Chemical Society 2025, 147, 8917–8927. doi:10.1021/jacs.5c00830
• Panja, S.; Pan, A.; Biswas, S.; Das, C.; Guha, A.; Nimje, R. Y.; Murali Dhar, T. G.; Gupta, A.; Mathur, A.; Dutta, A.; Roy, L.; Maiti, D. Pallada-Electrocatalysis Enables Distal Regioselective and Atroposelective Olefination Reactions. Angewandte Chemie (International ed. in English) 2025, e202422876. doi:10.1002/anie.202422876
• Song, J.; Guo, C.; Li, J. Enantioselective Electrocatalytic Nitroalkylation. Synlett 2025. doi:10.1055/a-2535-0710
• Jiang, X.; Zou, C.; Zhuang, W.; Li, R.; Yang, Y.; Yang, C.; Xu, X.; Zhang, L.; He, X.; Yao, Y.; Sun, X.; Hu, W. (Walter). Asymmetric electrosynthesis: emerging catalytic strategies and mechanistic insights. Green Chemistry 2025, 27, 915–945. doi:10.1039/d4gc05316h
• Li, J.; Liu, M.; Wei, B.; Peng, L.; Song, J.; Guo, C. Enantioselective Nickel-Electrocatalyzed Cross-Dehydrogenative α- and γ-Nitroalkylation. Journal of the American Chemical Society 2024, 146, 34043–34052. doi:10.1021/jacs.4c13109
• Stephen, H. R.; Röckl, J. L. The Future of Electro-organic Synthesis in Drug Discovery and Early Development. ACS organic & inorganic Au 2024, 4, 571–578. doi:10.1021/acsorginorgau.4c00068
• Liang, K.; Li, N.; Liu, M.; Song, J.; Guo, C. Enantioselective Electrocatalysis for Cross‐Dehydrogenative Heteroarylation with Indoles, Pyrroles, and Furans. Angewandte Chemie 2024, 137. doi:10.1002/ange.202415723
• Liang, K.; Li, N.; Liu, M.; Song, J.; Guo, C. Enantioselective Electrocatalysis for Cross-Dehydrogenative Heteroarylation with Indoles, Pyrroles, and Furans. Angewandte Chemie (International ed. in English) 2024, 64, e202415723. doi:10.1002/anie.202415723
• He, J.; Wang, N.; Zhao, R.; Kong, L.; Zhu, C.; Mei, T.; Xu, H. Organocatalyzed Electrochemical Enantioselective α‐Alkylation of Aldehydes with 9,10‐Dihydroacridines. European Journal of Organic Chemistry 2024, 27. doi:10.1002/ejoc.202400817
• Naulin, E.; Brion, A.; Biatuma, D.; Roulland, E.; Genta-Jouve, G.; Neuville, L.; Masson, G. Stereoselective synthesis of fissoldhimine alkaloid analogues via sequential electrooxidation and heterodimerization of ureas. Chemical communications (Cambridge, England) 2024, 60, 11560–11563. doi:10.1039/d4cc02616k
• Hawkins, B. C.; Chalker, J. M.; Coote, M. L.; Bissember, A. C. Electrochemically Generated Carbocations in Organic Synthesis. Angewandte Chemie 2024, 136. doi:10.1002/ange.202407207
• Hawkins, B. C.; Chalker, J. M.; Coote, M. L.; Bissember, A. C. Electrochemically Generated Carbocations in Organic Synthesis. Angewandte Chemie (International ed. in English) 2024, 63, e202407207. doi:10.1002/anie.202407207
• Zou, L.; Zheng, X.; Yi, X.; Lu, Q. Asymmetric paired oxidative and reductive catalysis enables enantioselective alkylarylation of olefins with C(sp3)-H bonds. Nature communications 2024, 15, 7826. doi:10.1038/s41467-024-52248-y
• Xi, L.-L.; Liu, R.-R. Enantioselective electrochemical and photochemical synthesis of atropisomers. Trends in Chemistry 2024, 6, 556–571. doi:10.1016/j.trechm.2024.06.013
• Tao, Y.; Ma, W.; Sun, R.; Huang, C.; Lu, Q. Asymmetric Paired Electrolysis: Enantioselective Alkylation of Sulfonylimines via C(sp3)-H Functionalization. Angewandte Chemie (International ed. in English) 2024, 63, e202409222. doi:10.1002/anie.202409222

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