Bacterial terpene biosynthesis: challenges and opportunities for pathway engineering

Eric J. N. Helfrich, Geng-Min Lin, Christopher A. Voigt and Jon Clardy
Beilstein J. Org. Chem. 2019, 15, 2889–2906. https://doi.org/10.3762/bjoc.15.283

Supporting Information

Supporting Information File 1: Additional figures and tables.
Format: PDF Size: 749.6 KB Download

Cite the Following Article

Bacterial terpene biosynthesis: challenges and opportunities for pathway engineering
Eric J. N. Helfrich, Geng-Min Lin, Christopher A. Voigt and Jon Clardy
Beilstein J. Org. Chem. 2019, 15, 2889–2906. https://doi.org/10.3762/bjoc.15.283

How to Cite

Helfrich, E. J. N.; Lin, G.-M.; Voigt, C. A.; Clardy, J. Beilstein J. Org. Chem. 2019, 15, 2889–2906. doi:10.3762/bjoc.15.283

Download Citation

Citation data can be downloaded as file using the "Download" button or used for copy/paste from the text window below.
Citation data in RIS format can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Zotero.

Presentation Graphic

Picture with graphical abstract, title and authors for social media postings and presentations.
Format: PNG Size: 531.2 KB Download

Citations to This Article

Up to 20 of the most recent references are displayed here.

Scholarly Works

  • Patil, R. S.; Sharma, S.; Bhaskarwar, A. V.; Nambiar, S.; Bhat, N. A.; Koppolu, M. K.; Bhukya, H. TetR and OmpR family regulators in natural product biosynthesis and resistance. Proteins 2023. doi:10.1002/prot.26621
  • Ndao, A.; Adjallé, K. Overview of the Biotransformation of Limonene and α-Pinene from Wood and Citrus Residues by Microorganisms. Waste 2023, 1, 841–859. doi:10.3390/waste1040049
  • Hares, M. F.; Griffiths, B. E.; Johnson, F.; Nelson, C.; Haldenby, S.; Stewart, C. J.; Duncan, J. S.; Oikonomou, G.; Coombes, J. L. Specific pathway abundances in the neonatal calf faecal microbiome are associated with susceptibility to Cryptosporidium parvum infection: a metagenomic analysis. Animal microbiome 2023, 5, 43. doi:10.1186/s42523-023-00265-5
  • Scesa, P. D.; Schmidt, E. W. Biomimetic Approach to Diverse Coral Diterpenes from a Biosynthetic Scaffold. Angewandte Chemie (International ed. in English) 2023, 62, e202311406. doi:10.1002/anie.202311406
  • Scesa, P. D.; Schmidt, E. W. Biomimetic Approach to Diverse Coral Diterpenes from a Biosynthetic Scaffold. Angewandte Chemie 2023, 135. doi:10.1002/ange.202311406
  • Mendes, L. W.; Raaijmakers, J. M.; de Hollander, M.; Sepo, E.; Gómez Expósito, R.; Chiorato, A. F.; Mendes, R.; Tsai, S. M.; Carrión, V. J. Impact of the fungal pathogen Fusarium oxysporum on the taxonomic and functional diversity of the common bean root microbiome. Environmental microbiome 2023, 18, 68. doi:10.1186/s40793-023-00524-7
  • Ivanova, A. A.; Naumoff, D. G.; Kulichevskaya, I. S.; Meshcheriakova, A. A.; Dedysh, S. N. Paludisphaera mucosa sp. nov., a Novel Planctomycete of the Family Isosphaeraceae from a Boreal Fen. Microbiology 2023, 92, 483–492. doi:10.1134/s0026261723600921
  • Tarasova, E. V.; Luchnikova, N. A.; Grishko, V. V.; Ivshina, I. B. Actinomycetes as Producers of Biologically Active Terpenoids: Current Trends and Patents. Pharmaceuticals (Basel, Switzerland) 2023, 16, 872. doi:10.3390/ph16060872
  • Gohil, P.; Nanavati, B.; Patel, K.; Suthar, V.; Joshi, M.; Patil, D. B.; Joshi, C. G. Assessing the efficacy of probiotics in augmenting bovine reproductive health: an integrated in vitro, in silico, and in vivo study. Frontiers in microbiology 2023, 14, 1137611. doi:10.3389/fmicb.2023.1137611
  • Hares, M. F.; Griffiths, B. E.; Johnson, F.; Nelson, C.; Haldenby, S.; Stewart, C. J.; Duncan, J. S.; Oikonomou, G.; Coombes, J. Specific pathway abundances in the neonatal calf faecal microbiome are associated with susceptibility to Cryptosporidium parvum infection: A metagenomic analysis. Research Square Platform LLC 2023. doi:10.21203/rs.3.rs-2844476/v1
  • Bathe, U.; Schmidt, J.; Frolov, A.; Soboleva, A.; Frank, O.; Dawid, C.; Tissier, A. Production of 130 diterpenoids by combinatorial biosynthesis in yeast. Cold Spring Harbor Laboratory 2023. doi:10.1101/2023.03.24.534067
  • Ko, S.-R.; Le, V. V.; Kang, M.; Oh, H.-M.; Ahn, C.-Y. Mucilaginibacter straminoryzae sp. nov., isolated from rice straw used for growing periphyton. International journal of systematic and evolutionary microbiology 2023, 73. doi:10.1099/ijsem.0.005714
  • Wu, C.; Zhang, F.; Dewer, Y.; Zhang, J.; Li, F. Exploration of Candidate Genes Involved in the Biosynthesis, Regulation and Recognition of the Male-Produced Aggregation Pheromone of Halyomorpha halys. Insects 2023, 14, 163. doi:10.3390/insects14020163
  • Ritz, M.; Ahmad, N.; Brueck, T.; Mehlmer, N. Comparative Genome-Wide Analysis of Two Caryopteris x Clandonensis Cultivars: Insights on the Biosynthesis of Volatile Terpenoids. Plants (Basel, Switzerland) 2023, 12, 632. doi:10.3390/plants12030632
  • Biermann, F.; Wenski, S. L.; Helfrich, E. J. N. Navigating and expanding the roadmap of natural product genome mining tools. Beilstein journal of organic chemistry 2022, 18, 1656–1671. doi:10.3762/bjoc.18.178
  • Sánchez-Navarro, R.; Nuhamunada, M.; Mohite, O. S.; Wasmund, K.; Albertsen, M.; Gram, L.; Nielsen, P. H.; Weber, T.; Singleton, C. M. Long-Read Metagenome-Assembled Genomes Improve Identification of Novel Complete Biosynthetic Gene Clusters in a Complex Microbial Activated Sludge Ecosystem. mSystems 2022, 7, e0063222. doi:10.1128/msystems.00632-22
  • Stowell, E. A.; Ehrenberger, M. A.; Lin, Y.-L.; Chang, C.-Y.; Rudolf, J. D. Structure-guided product determination of the bacterial type II diterpene synthase Tpn2. Communications chemistry 2022, 5, 146. doi:10.1038/s42004-022-00765-6
  • Leonardo, I. C.; Barreto Crespo, M. T.; Gaspar, F. B. Unveiling the complete genome sequence of Alicyclobacillus acidoterrestris DSM 3922T, a taint-producing strain. G3 (Bethesda, Md.) 2022, 12. doi:10.1093/g3journal/jkac225
  • Faylo, J. L.; van Eeuwen, T.; Gupta, K.; Murakami, K.; Christianson, D. W. Transient Prenyltransferase-Cyclase Association in Fusicoccadiene Synthase, an Assembly-Line Terpene Synthase. Biochemistry 2022, 61, 2417–2430. doi:10.1021/acs.biochem.2c00509
  • Kwak, S.; Crook, N.; Yoneda, A.; Ahn, N.; Ning, J.; Cheng, J.; Dantas, G. Functional mining of novel terpene synthases from metagenomes. Biotechnology for biofuels and bioproducts 2022, 15, 104. doi:10.1186/s13068-022-02189-9
Other Beilstein-Institut Open Science Activities