Selectivity in multiple multicomponent reactions: types and synthetic applications

Scholarly Works

• Gunaseeli, P. I.; Ruban, Y. J. V.; Venkatesan, K. Microwave Assisted Synthesis and Biological Studies of Phenothiazine-Based Imidazole Derivatives. Russian Journal of General Chemistry 2025, 95, 1068–1074. doi:10.1134/s1070363225600249
• Zhu, Z.; Wu, J. Nickel-Catalyzed Enantioselective Three-Component 1,2-Alkylarylation of Alkenes with Arylboronic Acids as Arylation Reagents. ACS Catalysis 2025, 15, 7833–7841. doi:10.1021/acscatal.5c01514
• Zhang, M.; Yang, X.; Fu, X.; Zhou, X.; Qian, Y.; Hu, W. Chemo- and diastereoselective four-component reactions with Rh carbynoids. Green Synthesis and Catalysis 2025, 6, 101–105. doi:10.1016/j.gresc.2024.10.006
• Barani, K. K.; Khandan, S.; Shirangi, H. S.; Tabarsaei, N. Investigation of the Biological Activity of Pyrrolo[1,2-a]imidazole Derivatives Produced by a Green One-Pot Multicomponent Synthesis of Ninhydrins. Combinatorial chemistry & high throughput screening 2025, 28, 1737–1745. doi:10.2174/0113862073298187240524053210
• Khaligh, N. G.; Titinchi, S. J.; Abbo, H. S. Metal-free Knoevenagel Condensation and Other Condensation Reactions (Perkin, Darzens). Comprehensive Organic Synthesis; Elsevier, 2025; pp 597–644. doi:10.1016/b978-0-323-96025-0.00075-2
• Ramiro, J. L.; Marcos, C. F.; Neo, A. G. Synthesis of coumarin dimers by a microwave-assisted double multicomponent reaction. Sustainable Chemistry and Pharmacy 2024, 42, 101792. doi:10.1016/j.scp.2024.101792
• Javahershenas, R.; Soloshonok, V. A.; Klika, K. D.; Jervis, P. J. Carbon nanotubes as heterogeneous catalysts for the multicomponent reaction synthesis of heterocycles. Carbon Letters 2024, 35, 75–105. doi:10.1007/s42823-024-00818-x
• Javahershenas, R.; Han, J.; Kazemi, M.; Jervis, P. J. Recent Advances in the Application of 2-Aminobenzothiazole to the Multicomponent Synthesis of Heterocycles. ChemistryOpen 2024, 13, e202400185. doi:10.1002/open.202400185
• Javahershenas, R.; Han, J.; Kazemi, M.; Jervis, P. J. Recent Advances in the Multicomponent Synthesis of Heterocycles using Thiosemicarbazide. ChemistrySelect 2024, 9. doi:10.1002/slct.202401496
• Motamed, N. K.; Larijani, K.; Pournamdari, E.; Saeidian, H.; Hargalani, F. Z. One pot multicomponent reaction of curcumin: Green synthesis of novel 1,4‐dihydropyridine‐2,3‐dicarboxylates. Journal of Heterocyclic Chemistry 2024, 61, 1306–1313. doi:10.1002/jhet.4857
• Javahershenas, R.; Makarem, A.; Klika, K. D. Recent advances in microwave-assisted multicomponent synthesis of spiro heterocycles. RSC advances 2024, 14, 5547–5565. doi:10.1039/d4ra00056k
• Pich, R.; Mallet‐Ladeira, S.; Lavedan, P.; Lahitte, J.; Remigy, J.; Pla, D.; Gómez, M. A Mechanistic Insight on CuI‐Catalyzed Synthesis of Oxazolidinones through a Four‐Component Reaction. Advanced Synthesis & Catalysis 2024, 366, 822–829. doi:10.1002/adsc.202301303
• Mohamed, M. A.; Abouzied, A. S.; Reyad, A.; Sayed Abdelsalam Zaki, M. E.; Abdelgawad, F. E.; Al-Humaidi, J. Y.; Gomha, S. M. Novel terpyridines as Staphylococcus aureus gyrase inhibitors: efficient synthesis and antibacterial assessment via solvent-drop grinding. Future medicinal chemistry 2024, 16, 205–220. doi:10.4155/fmc-2023-0278
• Javahershenas, R.; Makarem, A.; Mei, H.; Koley, M.; Soloshonok, V. A. Recent Advances in the Multicomponent Synthesis of Heterocycles Using 5-Aminotetrazole. Synthesis 2024, 56, 2445–2461. doi:10.1055/s-0042-1751526
• Johari, S.; Johan, M. R.; Khaligh, N. G. How Important is the Metal-free Catalytic Knoevenagel Reaction in Medicinal Chemistry? An Updated Review. Current medicinal chemistry 2024, 31, 4286–4311. doi:10.2174/0109298673260463231122074253
• Javahershenas, R.; Nikzat, S. Recent developments using malononitrile in ultrasound-assisted multicomponent synthesis of heterocycles. Ultrasonics sonochemistry 2023, 102, 106741. doi:10.1016/j.ultsonch.2023.106741
• Mei, L.; Shu, X.-R.; Liu, F.-L.; Li, J.-Z.; Zhang, J.-F.; Tang, K.; Wei, W.-T. Multicomponent hydrosulfonylation of alkynes for the synthesis of vinyl sulfones. Green Chemistry 2023, 25, 8820–8825. doi:10.1039/d3gc02284f
• Sakthivel, K.; Gana, R. J.; Shoji, T.; Takenaga, N.; Dohi, T.; Singh, F. V. Recent progress in metal assisted multicomponent reactions in organic synthesis. Frontiers in chemistry 2023, 11, 1217744. doi:10.3389/fchem.2023.1217744
• Javahershenas, R. Recent advances in the application of deep eutectic solvents for the synthesis of Spiro heterocyclic scaffolds via multicomponent reactions. Journal of Molecular Liquids 2023, 385, 122398. doi:10.1016/j.molliq.2023.122398
• Yakkanti, C.; L, V. R.; Kerru, N.; Gorle, S.; Madhavaram, S.; Akula, R.; Bhaskaruni, S. V. H. S. One-Pot Multi-Component Synthesis of Polysubstituted Pyridines Using DBU-SiO 2 as a Robust Recyclable Catalyst. Polycyclic Aromatic Compounds 2023, 44, 2855–2862. doi:10.1080/10406638.2023.2225673

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