Multicomponent reactions III

  1. editorImage
  1. Editor: Prof. Thomas J. J. Müller
    Heinrich-Heine-Universität Düsseldorf

Multicomponent reactions (MCR) are highly efficient one-pot processes, where three or more compounds are selectively transformed into a product that contains substantial amounts of the starting materials atoms. These sequences proceed as a reactivity-based concept by the perpetual generation of reactive functionalities, void of any isolation intermediate products. In their nature MCR are particularly interesting for exploring huge structural and functional spaces, a domain of the development of active pharmaceutical ingredients, and increasingly more, of functional organic materials. 

This thematic issue on multicomponent reactions continues the previously released two series presenting again a snap shot view on a highly dynamic field.

Mn-mediated sequential three-component domino Knoevenagel/cyclization/Michael addition/oxidative cyclization reaction towards annulated imidazo[1,2-a]pyridines

  1. Olga A. Storozhenko,
  2. Alexey A. Festa,
  3. Delphine R. Bella Ndoutoume,
  4. Alexander V. Aksenov,
  5. Alexey V. Varlamov and
  6. Leonid G. Voskressensky
  • Full Research Paper
  • Published 19 Dec 2018

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  • Supp. Info

Beilstein J. Org. Chem. 2018, 14, 3078–3087, doi:10.3762/bjoc.14.287

  • Full Research Paper
  • Published 15 Feb 2019

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  • Supp. Info

Beilstein J. Org. Chem. 2019, 15, 469–473, doi:10.3762/bjoc.15.40

Design of indole- and MCR-based macrocycles as p53-MDM2 antagonists

  1. Constantinos G. Neochoritis,
  2. Maryam Kazemi Miraki,
  3. Eman M. M. Abdelraheem,
  4. Ewa Surmiak,
  5. Tryfon Zarganes-Tzitzikas,
  6. Beata Łabuzek,
  7. Tad A. Holak and
  8. Alexander Dömling
  • Full Research Paper
  • Published 20 Feb 2019

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  • Supp. Info

Beilstein J. Org. Chem. 2019, 15, 513–520, doi:10.3762/bjoc.15.45

Selectivity in multiple multicomponent reactions: types and synthetic applications

  1. Ouldouz Ghashghaei,
  2. Francesca Seghetti and
  3. Rodolfo Lavilla
  • Review
  • Published 21 Feb 2019

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Beilstein J. Org. Chem. 2019, 15, 521–534, doi:10.3762/bjoc.15.46

  • Letter
  • Published 27 Feb 2019

Beilstein J. Org. Chem. 2019, 15, 571–576, doi:10.3762/bjoc.15.52

Catalyst-free assembly of giant tris(heteroaryl)methanes: synthesis of novel pharmacophoric triads and model sterically crowded tris(heteroaryl/aryl)methyl cation salts

  1. Rodrigo Abonia,
  2. Luisa F. Gutiérrez,
  3. Braulio Insuasty,
  4. Jairo Quiroga,
  5. Kenneth K. Laali,
  6. Chunqing Zhao,
  7. Gabriela L. Borosky,
  8. Samantha M. Horwitz and
  9. Scott D. Bunge
  • Full Research Paper
  • Published 12 Mar 2019

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  • Supp. Info

Beilstein J. Org. Chem. 2019, 15, 642–654, doi:10.3762/bjoc.15.60

  • Review
  • Published 13 Mar 2019

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Beilstein J. Org. Chem. 2019, 15, 655–678, doi:10.3762/bjoc.15.61

  • Full Research Paper
  • Published 04 Apr 2019

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  • Supp. Info

Beilstein J. Org. Chem. 2019, 15, 852–857, doi:10.3762/bjoc.15.82

  • Review
  • Published 15 Apr 2019

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Beilstein J. Org. Chem. 2019, 15, 906–930, doi:10.3762/bjoc.15.88

Novel (2-amino-4-arylimidazolyl)propanoic acids and pyrrolo[1,2-c]imidazoles via the domino reactions of 2-amino-4-arylimidazoles with carbonyl and methylene active compounds

  1. Victoria V. Lipson,
  2. Tetiana L. Pavlovska,
  3. Nataliya V. Svetlichnaya,
  4. Anna A. Poryvai,
  5. Nikolay Yu. Gorobets,
  6. Erik V. Van der Eycken,
  7. Irina S. Konovalova,
  8. Svetlana V. Shiskina,
  9. Alexander V. Borisov,
  10. Vladimir I. Musatov and
  11. Alexander V. Mazepa
  • Full Research Paper
  • Published 06 May 2019

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Beilstein J. Org. Chem. 2019, 15, 1032–1045, doi:10.3762/bjoc.15.101

A three-component, Zn(OTf)2-mediated entry into trisubstituted 2-aminoimidazoles

  1. Alexei Lukin,
  2. Anna Bakholdina,
  3. Anna Kryukova,
  4. Alexander Sapegin and
  5. Mikhail Krasavin
  • Letter
  • Published 07 May 2019

Beilstein J. Org. Chem. 2019, 15, 1061–1064, doi:10.3762/bjoc.15.103

Multicomponent reactions (MCRs): a useful access to the synthesis of benzo-fused γ-lactams

  1. Edorta Martínez de Marigorta,
  2. Jesús M. de Los Santos,
  3. Ana M. Ochoa de Retana,
  4. Javier Vicario and
  5. Francisco Palacios
  • Review
  • Published 08 May 2019

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Beilstein J. Org. Chem. 2019, 15, 1065–1085, doi:10.3762/bjoc.15.104

Ugi reaction-derived prolyl peptide catalysts grafted on the renewable polymer polyfurfuryl alcohol for applications in heterogeneous enamine catalysis

  1. Alexander F. de la Torre,
  2. Gabriel S. Scatena,
  3. Oscar Valdés,
  4. Daniel G. Rivera and
  5. Márcio W. Paixão
  • Full Research Paper
  • Published 04 Jun 2019

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Beilstein J. Org. Chem. 2019, 15, 1210–1216, doi:10.3762/bjoc.15.118

Steroid diversification by multicomponent reactions

  1. Leslie Reguera,
  2. Cecilia I. Attorresi,
  3. Javier A. Ramírez and
  4. Daniel G. Rivera
  • Review
  • Published 06 Jun 2019

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Beilstein J. Org. Chem. 2019, 15, 1236–1256, doi:10.3762/bjoc.15.121

Doebner-type pyrazolopyridine carboxylic acids in an Ugi four-component reaction

  1. Maryna V. Murlykina,
  2. Oleksandr V. Kolomiets,
  3. Maryna M. Kornet,
  4. Yana I. Sakhno,
  5. Sergey M. Desenko,
  6. Victoriya V. Dyakonenko,
  7. Svetlana V. Shishkina,
  8. Oleksandr A. Brazhko,
  9. Vladimir I. Musatov,
  10. Alexander V. Tsygankov,
  11. Erik V. Van der Eycken and
  12. Valentyn A. Chebanov
  • Full Research Paper
  • Published 12 Jun 2019

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Beilstein J. Org. Chem. 2019, 15, 1281–1288, doi:10.3762/bjoc.15.126

One-pot activation–alkynylation–cyclization synthesis of 1,5-diacyl-5-hydroxypyrazolines in a consecutive three-component fashion

  1. Christina Görgen,
  2. Katharina Boden,
  3. Guido J. Reiss,
  4. Walter Frank and
  5. Thomas J. J. Müller
  • Full Research Paper
  • Published 19 Jun 2019

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  • Supp. Info

Beilstein J. Org. Chem. 2019, 15, 1360–1370, doi:10.3762/bjoc.15.136

  • Full Research Paper
  • Published 27 Jun 2019

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Beilstein J. Org. Chem. 2019, 15, 1425–1433, doi:10.3762/bjoc.15.142

  • Full Research Paper
  • Published 10 Jul 2019

Beilstein J. Org. Chem. 2019, 15, 1523–1533, doi:10.3762/bjoc.15.155

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