Multicomponent reactions III

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Editor: Prof. Thomas J. J. Müller
Heinrich-Heine-Universität Düsseldorf
 

Multicomponent reactions (MCR) are highly efficient one-pot processes, where three or more compounds are selectively transformed into a product that contains substantial amounts of the starting materials atoms. These sequences proceed as a reactivity-based concept by the perpetual generation of reactive functionalities, void of any isolation intermediate products. In their nature MCR are particularly interesting for exploring huge structural and functional spaces, a domain of the development of active pharmaceutical ingredients, and increasingly more, of functional organic materials. 

This thematic issue on multicomponent reactions continues the previously released two series presenting again a snap shot view on a highly dynamic field.

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Multicomponent reactions III

  • Thomas J. J. Müller

Beilstein J. Org. Chem. 2019, 15, 1974–1975, doi:10.3762/bjoc.15.192

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Published 20 Aug 2019

Mn-mediated sequential three-component domino Knoevenagel/cyclization/Michael addition/oxidative cyclization reaction towards annulated imidazo[1,2-a]pyridines

  • Olga A. Storozhenko,
  • Alexey A. Festa,
  • Delphine R. Bella Ndoutoume,
  • Alexander V. Aksenov,
  • Alexey V. Varlamov and
  • Leonid G. Voskressensky

Beilstein J. Org. Chem. 2018, 14, 3078–3087, doi:10.3762/bjoc.14.287

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Published 19 Dec 2018

Microwave-assisted synthesis of N,N-bis(phosphinoylmethyl)amines and N,N,N-tris(phosphinoylmethyl)amines bearing different substituents on the phosphorus atoms

  • Erika Bálint,
  • Anna Tripolszky,
  • László Hegedűs and
  • György Keglevich

Beilstein J. Org. Chem. 2019, 15, 469–473, doi:10.3762/bjoc.15.40

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Published 15 Feb 2019

Design of indole- and MCR-based macrocycles as p53-MDM2 antagonists

  • Constantinos G. Neochoritis,
  • Maryam Kazemi Miraki,
  • Eman M. M. Abdelraheem,
  • Ewa Surmiak,
  • Tryfon Zarganes-Tzitzikas,
  • Beata Łabuzek,
  • Tad A. Holak and
  • Alexander Dömling

Beilstein J. Org. Chem. 2019, 15, 513–520, doi:10.3762/bjoc.15.45

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Published 20 Feb 2019

Selectivity in multiple multicomponent reactions: types and synthetic applications

  • Ouldouz Ghashghaei,
  • Francesca Seghetti and
  • Rodolfo Lavilla

Beilstein J. Org. Chem. 2019, 15, 521–534, doi:10.3762/bjoc.15.46

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Published 21 Feb 2019

Catalyst-free assembly of giant tris(heteroaryl)methanes: synthesis of novel pharmacophoric triads and model sterically crowded tris(heteroaryl/aryl)methyl cation salts

  • Rodrigo Abonia,
  • Luisa F. Gutiérrez,
  • Braulio Insuasty,
  • Jairo Quiroga,
  • Kenneth K. Laali,
  • Chunqing Zhao,
  • Gabriela L. Borosky,
  • Samantha M. Horwitz and
  • Scott D. Bunge

Beilstein J. Org. Chem. 2019, 15, 642–654, doi:10.3762/bjoc.15.60

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Published 12 Mar 2019

The LANCA three-component reaction to highly substituted β-ketoenamides – versatile intermediates for the synthesis of functionalized pyridine, pyrimidine, oxazole and quinoxaline derivatives

  • Tilman Lechel,
  • Roopender Kumar,
  • Mrinal K. Bera,
  • Reinhold Zimmer and
  • Hans-Ulrich Reissig

Beilstein J. Org. Chem. 2019, 15, 655–678, doi:10.3762/bjoc.15.61

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Published 13 Mar 2019

Synthesis of a novel category of pseudo-peptides using an Ugi three-component reaction of levulinic acid as bifunctional substrate, amines, and amino acid-based isocyanides

  • Maryam Khalesi,
  • Azim Ziyaei Halimehjani and
  • Jürgen Martens

Beilstein J. Org. Chem. 2019, 15, 852–857, doi:10.3762/bjoc.15.82

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Published 04 Apr 2019

Synthesis of (macro)heterocycles by consecutive/repetitive isocyanide-based multicomponent reactions

  • Angélica de Fátima S. Barreto and
  • Carlos Kleber Z. Andrade

Beilstein J. Org. Chem. 2019, 15, 906–930, doi:10.3762/bjoc.15.88

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Published 15 Apr 2019

Novel (2-amino-4-arylimidazolyl)propanoic acids and pyrrolo[1,2-c]imidazoles via the domino reactions of 2-amino-4-arylimidazoles with carbonyl and methylene active compounds

  • Victoria V. Lipson,
  • Tetiana L. Pavlovska,
  • Nataliya V. Svetlichnaya,
  • Anna A. Poryvai,
  • Nikolay Yu. Gorobets,
  • Erik V. Van der Eycken,
  • Irina S. Konovalova,
  • Svetlana V. Shiskina,
  • Alexander V. Borisov,
  • Vladimir I. Musatov and
  • Alexander V. Mazepa

Beilstein J. Org. Chem. 2019, 15, 1032–1045, doi:10.3762/bjoc.15.101

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Published 06 May 2019

A three-component, Zn(OTf)2-mediated entry into trisubstituted 2-aminoimidazoles

  • Alexei Lukin,
  • Anna Bakholdina,
  • Anna Kryukova,
  • Alexander Sapegin and
  • Mikhail Krasavin

Beilstein J. Org. Chem. 2019, 15, 1061–1064, doi:10.3762/bjoc.15.103

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Published 07 May 2019

Multicomponent reactions (MCRs): a useful access to the synthesis of benzo-fused γ-lactams

  • Edorta Martínez de Marigorta,
  • Jesús M. de Los Santos,
  • Ana M. Ochoa de Retana,
  • Javier Vicario and
  • Francisco Palacios

Beilstein J. Org. Chem. 2019, 15, 1065–1085, doi:10.3762/bjoc.15.104

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Published 08 May 2019

Ugi reaction-derived prolyl peptide catalysts grafted on the renewable polymer polyfurfuryl alcohol for applications in heterogeneous enamine catalysis

  • Alexander F. de la Torre,
  • Gabriel S. Scatena,
  • Oscar Valdés,
  • Daniel G. Rivera and
  • Márcio W. Paixão

Beilstein J. Org. Chem. 2019, 15, 1210–1216, doi:10.3762/bjoc.15.118

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Published 04 Jun 2019

Steroid diversification by multicomponent reactions

  • Leslie Reguera,
  • Cecilia I. Attorresi,
  • Javier A. Ramírez and
  • Daniel G. Rivera

Beilstein J. Org. Chem. 2019, 15, 1236–1256, doi:10.3762/bjoc.15.121

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Published 06 Jun 2019

Doebner-type pyrazolopyridine carboxylic acids in an Ugi four-component reaction

  • Maryna V. Murlykina,
  • Oleksandr V. Kolomiets,
  • Maryna M. Kornet,
  • Yana I. Sakhno,
  • Sergey M. Desenko,
  • Victoriya V. Dyakonenko,
  • Svetlana V. Shishkina,
  • Oleksandr A. Brazhko,
  • Vladimir I. Musatov,
  • Alexander V. Tsygankov,
  • Erik V. Van der Eycken and
  • Valentyn A. Chebanov

Beilstein J. Org. Chem. 2019, 15, 1281–1288, doi:10.3762/bjoc.15.126

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Published 12 Jun 2019

One-pot activation–alkynylation–cyclization synthesis of 1,5-diacyl-5-hydroxypyrazolines in a consecutive three-component fashion

  • Christina Görgen,
  • Katharina Boden,
  • Guido J. Reiss,
  • Walter Frank and
  • Thomas J. J. Müller

Beilstein J. Org. Chem. 2019, 15, 1360–1370, doi:10.3762/bjoc.15.136

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Published 19 Jun 2019

Efficiency Effsyn of complex syntheses as multicomponent reactions, its algorithm and calculations based on concrete criteria

  • Heiner Eckert

Beilstein J. Org. Chem. 2019, 15, 1425–1433, doi:10.3762/bjoc.15.142

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Published 27 Jun 2019

A novel three-component reaction between isocyanides, alcohols or thiols and elemental sulfur: a mild, catalyst-free approach towards O-thiocarbamates and dithiocarbamates

  • András György Németh,
  • György Miklós Keserű and
  • Péter Ábrányi-Balogh

Beilstein J. Org. Chem. 2019, 15, 1523–1533, doi:10.3762/bjoc.15.155

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Published 10 Jul 2019
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