An improved synthesis of adefovir and related analogues

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• Stirn, J.; Klein, C. D. Efficient Acyloxymethylation of Psilocin and Other Tryptamines Yielding ACOM Prodrugs for Psychedelic-Assisted Therapy. Archiv der Pharmazie 2025, 358, e70022. doi:10.1002/ardp.70022
• Varikuppla, P.; Adusumalli, M. S. K.; Merugu, R.; Mittapelli, V. Synthesis, Biological Evaluation, and Molecular Docking Studies of (( S )‐7‐(Dibenzylamino)‐3‐(1‐Substituted‐Pyrrolidin‐3‐yl)‐3 H ‐Imidazo[4,5‐ d ]Pyrimidines as Anti‐Inflammatory Agents. ChemistrySelect 2025, 10. doi:10.1002/slct.202500192
• Yao, H.; Zheng, X.; Liu, M.; Xu, Y.; Xu, P.; Chen, F.-E. Synthesis of nucleoside drugs for the treatment of HBV infection: An updated review. Green Synthesis and Catalysis 2025. doi:10.1016/j.gresc.2025.06.001
• Kaur, S.; Harvey, J.; Van Meervelt, L.; Kirschhock, C. E. A. Crystal structures of potassium and cesium salts of adenine: the role of alkali cations. CrystEngComm 2024, 26, 6805–6812. doi:10.1039/d4ce00892h
• Buyens, D. M. S.; Pilcher, L. A.; Roduner, E. Reaction Kinetics of the Benzylation of Adenine in DMSO: Regio-Selectivity Guided by Entropy. Chemphyschem : a European journal of chemical physics and physical chemistry 2024, 25, e202400561. doi:10.1002/cphc.202400561
• Shi, X.; Qu, H.; Wu, Y.; Wang, F.; Chen, C. Selective C2 and C3 phosphorylmethylation of indoles with a phosphorylmethyl dibenzothiophenium reagent. Organic Chemistry Frontiers 2024, 11, 4176–4181. doi:10.1039/d4qo00611a
• M, S. G.; D, A.; N, V. Potential Drug-Drug Interactions with Adefovir Dipivoxil: Clinical Implications and Management Strategies. Biosciences Biotechnology Research Asia 2024, 21, 509–517. doi:10.13005/bbra/3243
• WANG, Z.; LIU, H.; WANG, Z.; YANG, X. A continuous synthesis method of hydroxymethyl phosphonates using the microfluidic reactor. Revue Roumaine de Chimie 2024, 68, 577–582. doi:10.33224/rrch.2023.68.10-12.10
• Buyens, D. M. S.; Pilcher, L. A.; Cukrowski, I. Coordination Sites for Sodium and Potassium Ions in Nucleophilic Adeninate Contact ion-Pairs: A Molecular-Wide and Electron Density-Based (MOWED) Perspective. Molecules (Basel, Switzerland) 2022, 27, 6111. doi:10.3390/molecules27186111
• Krečmerová, M.; Majer, P.; Rais, R.; Slusher, B. S. Phosphonates and Phosphonate Prodrugs in Medicinal Chemistry: Past Successes and Future Prospects. Frontiers in chemistry 2022, 10, 889737. doi:10.3389/fchem.2022.889737
• Rocha, D. H. A.; Machado, C. M.; Sousa, V. R. F.; Sousa, C. F. V.; Silva, V. L. M.; Silva, A. M. S.; Borges, J.; Mano, J. F. Customizable and Regioselective One-Pot N−H Functionalization of DNA Nucleobases to Create a Library of Nucleobase Derivatives for Biomedical Applications. European Journal of Organic Chemistry 2021, 2021, 4423–4433. doi:10.1002/ejoc.202100786
• Kirby, S. A.; Dowd, C. S. Phosphoryl prodrugs: characteristics to improve drug development. Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents 2021, 31, 1–10. doi:10.1007/s00044-021-02766-x
• Jones, D. J.; O'Leary, E. M.; O'Sullivan, T. P. Modern synthetic approaches to phosphorus-sulfur bond formation in organophosphorus compounds. Advanced Synthesis & Catalysis 2020, 362, 2801–2846. doi:10.1002/adsc.202000458
• Jones, D. J.; O'Leary, E. M.; O'Sullivan, T. P. A robust methodology for the synthesis of phosphorothioates, phosphinothioates and phosphonothioates. Advanced Synthesis & Catalysis 2020, 362, 1825–1830. doi:10.1002/adsc.202000059

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