Potent hemithioindigo-based antimitotics photocontrol the microtubule cytoskeleton in cellulo

Scholarly Works

• Seliwjorstow, A.; Takamiya, M.; Rastegar, S.; Pianowski, Z. Reversible Influence of Hemipiperazine Photochromism on the Early Development of Zebrafish Embryo. Chembiochem : a European journal of chemical biology 2024, e202400143. doi:10.1002/cbic.202400143
• Borys, F.; Tobiasz, P.; Fabczak, H.; Joachimiak, E.; Krawczyk, H. First-in-Class Colchicine-Based Visible Light Photoswitchable Microtubule Dynamics Disrupting Agent. Cells 2023, 12, 1866. doi:10.3390/cells12141866
• Kobauri, P.; Dekker, F. J.; Szymanski, W.; Feringa, B. L. Rational Design in Photopharmacology with Molecular Photoswitches. Angewandte Chemie 2023, 135. doi:10.1002/ange.202300681
• Kobauri, P.; Dekker, F. J.; Szymanski, W.; Feringa, B. L. Rational Design in Photopharmacology with Molecular Photoswitches. Angewandte Chemie (International ed. in English) 2023, 62, e202300681. doi:10.1002/anie.202300681
• Nakamura, A.; Rao, F.; Ukiya, K.; Matsunaga, R.; Ohira, S.-I.; Maegawa, T. A concise synthesis of thioaurones via NBS-induced cyclization of MOM-protected 2'-mercaptochalcones. Organic & biomolecular chemistry 2023, 21, 1134–1137. doi:10.1039/d2ob01995g
• Kirchner, S.; Leistner, A.-L.; Gödtel, P.; Seliwjorstow, A.; Weber, S.; Karcher, J.; Nieger, M.; Pianowski, Z. Hemipiperazines as peptide-derived molecular photoswitches with low-nanomolar cytotoxicity. Nature communications 2022, 13, 6066. doi:10.1038/s41467-022-33750-7
• Gao, L.; Kraus, Y.; Stegner, A.; Wein, T.; Heise, C.; von Brunn, L.; Fajardo-Ruiz, E.; Thorn-Seshold, J.; Thorn-Seshold, O. Self-reporting styrylthiazolium photopharmaceuticals: mitochondrial localisation as well as SAR drive biological activity. Organic & biomolecular chemistry 2022, 20, 7787–7794. doi:10.1039/d2ob00347c
• Lazinski, L. M.; Royal, G.; Robin, M.; Maresca, M.; Haudecoeur, R. Bioactive Aurones, Indanones, and Other Hemiindigoid Scaffolds: Medicinal Chemistry and Photopharmacology Perspectives. Journal of medicinal chemistry 2022, 65, 12594–12625. doi:10.1021/acs.jmedchem.2c01150
• Borys, F.; Tobiasz, P.; Sobel, J.; Krawczyk, H. Synthesis and Study of Dibenzo[b, f]oxepine Combined with Fluoroazobenzenes-New Photoswitches for Application in Biological Systems. Molecules (Basel, Switzerland) 2022, 27, 5836. doi:10.3390/molecules27185836
• Ewert, J.; Heintze, L.; Jordà-Redondo, M.; von Glasenapp, J.-S.; Nonell, S.; Bucher, G.; Peifer, C.; Herges, R. Photoswitchable Diazocine-Based Estrogen Receptor Agonists: Stabilization of the Active Form inside the Receptor. Journal of the American Chemical Society 2022, 144, 15059–15071. doi:10.1021/jacs.2c03649
• Thorn‐Seshold, O. doi:10.1002/9783527827626.ch36
• Kirchner, S.; Pianowski, Z. Photopharmacology of Antimitotic Agents. International journal of molecular sciences 2022, 23, 5657. doi:10.3390/ijms23105657
• Anwer, K. E.; Sayed, G. H.; Ramadan, R. M. Synthesis, spectroscopic, DFT calculations, biological activities and molecular docking studies of new isoxazolone, pyrazolone, triazine, triazole and amide derivatives. Journal of Molecular Structure 2022, 1256, 132513. doi:10.1016/j.molstruc.2022.132513
• Thorn-Seshold, O.; Meiring, J. C. M. Photocontrolling Microtubule Dynamics with Photoswitchable Chemical Reagents. Methods in molecular biology (Clifton, N.J.) 2022, 2430, 403–430. doi:10.1007/978-1-0716-1983-4_26
• Eli, S.; Castagna, R.; Mapelli, M.; Parisini, E. Recent Approaches to the Identification of Novel Microtubule-Targeting Agents. Frontiers in molecular biosciences 2022, 9, 841777. doi:10.3389/fmolb.2022.841777
• Gao, L.; Meiring, J. C. M.; Varady, A.; Ruider, I. E.; Heise, C.; Wranik, M.; Velasco, C. D.; Taylor, J. A.; Terni, B.; Weinert, T.; Standfuss, J.; Cabernard, C. C.; Llobet, A.; Steinmetz, M. O.; Bausch, A. R.; Distel, M.; Thorn-Seshold, J.; Akhmanova, A.; Thorn-Seshold, O. In Vivo Photocontrol of Microtubule Dynamics and Integrity, Migration and Mitosis, by the Potent GFP-Imaging-Compatible Photoswitchable Reagents SBTubA4P and SBTub2M. Journal of the American Chemical Society 2022, 144, 5614–5628. doi:10.1021/jacs.2c01020
• Gao, L.; Meiring, J. C. M.; Heise, C.; Rai, A.; Müller-Deku, A.; Akhmanova, A.; Thorn-Seshold, J.; Thorn-Seshold, O. Photoswitchable Epothilone-Based Microtubule Stabilisers Allow GFP-Imaging-Compatible, Optical Control over the Microtubule Cytoskeleton. Angewandte Chemie (International ed. in English) 2022, 61, e202114614. doi:10.1002/anie.202114614
• Gao, L.; Meiring, J. C. M.; Heise, C.; Rai, A.; Müller‐Deku, A.; Akhmanova, A.; Thorn‐Seshold, J.; Thorn‐Seshold, O. Photoswitchable Epothilone‐Based Microtubule Stabilisers Allow GFP‐Imaging‐Compatible, Optical Control over the Microtubule Cytoskeleton**. Angewandte Chemie 2022, 134. doi:10.1002/ange.202114614
• Impastato, A. C.; Shemet, A.; Vepřek, N. A.; Saper, G.; Hess, H.; Rao, L.; Gennerich, A.; Trauner, D. Optical Control of Mitosis with a Photoswitchable Eg5 Inhibitor. Angewandte Chemie (International ed. in English) 2022, 61, e202115846. doi:10.1002/anie.202115846
• Impastato, A. C.; Shemet, A.; Vepřek, N. A.; Saper, G.; Hess, H.; Rao, L.; Gennerich, A.; Trauner, D. Optical Control of Mitosis with a Photoswitchable Eg5 Inhibitor. Angewandte Chemie 2022, 134. doi:10.1002/ange.202115846

Explore citations to this article at