Synthesis, docking study and biological evaluation of ᴅ-fructofuranosyl and ᴅ-tagatofuranosyl sulfones as potential inhibitors of the mycobacterial galactan synthesis targeting the galactofuranosyltransferase GlfT2

Marek Baráth, Jana Jakubčinová, Zuzana Konyariková, Stanislav Kozmon, Katarína Mikušová and Maroš Bella

Beilstein J. Org. Chem. 2020, 16, 1853–1862. doi:10.3762/bjoc.16.152

Supporting Information

The Supporting Information provides the biochemical pathway for the biosynthesis of mycobacterial galactan, superimposition of docked structures and evaluation of the effects of the target compounds on the synthesis of the lipid-linked galactan polymer. Complete experimental procedures, spectral characterization of all prepared compounds and copies of their 1H NMR and 13C NMR spectra are also provided.

Supporting Information File 1: Experimental and analytical data.
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Picture with graphical abstract, title and authors for social media postings and presentations.

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