/ E-Alerts

Synthesis of 4-amino-5-fluoropyrimidines and 5-amino-4-fluoropyrazoles from a β-fluoroenolate salt

Tobias Lucas, Jule-Philipp Dietz and Till Opatz

Beilstein J. Org. Chem. 2020, 16, 445–450. https://doi.org/10.3762/bjoc.16.41

Supporting Information

Supporting Information File 1: Chemical procedures and analytical data, including copies of ¹H NMR and ¹³C NMR spectra.
Format: PDF	Size: 3.4 MB	Download

Cite the Following Article

Synthesis of 4-amino-5-fluoropyrimidines and 5-amino-4-fluoropyrazoles from a β-fluoroenolate salt

Tobias Lucas, Jule-Philipp Dietz and Till Opatz

Beilstein J. Org. Chem. 2020, 16, 445–450. https://doi.org/10.3762/bjoc.16.41

How to Cite

Lucas, T.; Dietz, J.-P.; Opatz, T. Beilstein J. Org. Chem. 2020, 16, 445–450. doi:10.3762/bjoc.16.41

Download Citation

Citation data can be downloaded as file using the "Download" button or used for copy/paste from the text window below.
Citation data in RIS format can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Zotero.

File format:

RIS

BibTeX

Include:

Citation for the article above

Citation and complete reference list for the article above

Download

TY  - JOUR
A1  - Lucas, Tobias
A1  - Dietz, Jule-Philipp
A1  - Opatz, Till
T1  - Synthesis of 4-amino-5-fluoropyrimidines and 5-amino-4-fluoropyrazoles from a β-fluoroenolate salt
JF  - Beilstein Journal of Organic Chemistry
PY  - 2020///
VL  - 16
SP  - 445
EP  - 450
SN  - 1860-5397
DO  - 10.3762/bjoc.16.41
PB  - Beilstein-Institut
JA  - Beilstein J. Org. Chem.
UR  - https://doi.org/10.3762/bjoc.16.41
KW  - cyclization
KW  - fluorinated heterocycles
KW  - fluorine
KW  - pyrazoles
KW  - pyrimidines
N2  - A synthesis of fluorinated pyrimidines under mild conditions from amidine hydrochlorides and the recently described potassium 2-cyano-2-fluoroethenolate was developed. A broad substrate scope was tested and mostly excellent yields were obtained. The synthesis of fluorinated aminopyrazoles from the same fluorinated precursor could be demonstrated but proceeded with lower efficiency.
ER  -

Presentation Graphic

Picture with graphical abstract, title and authors for social media postings and presentations.
Format: PNG	Size: 129.7 KB	Download

Citations to This Article

Up to 20 of the most recent references are displayed here.

Scholarly Works

Mykhailiuk, P. K. Fluorinated Pyrazoles: From Synthesis to Applications. Chemical reviews 2020, 121, 1670–1715. doi:10.1021/acs.chemrev.0c01015

Explore citations to this article at

Back To Article

Other Beilstein-Institut Open Science Activities

aromatic	the word “aromatic”
aromatic aldehyde	the word “aromatic” OR “aldehyde”
+aromatic +aldehyde	both words “aromatic” AND “aldehyde”
+aromatic -aldehyde	the word “aromatic” but NOT “aldehyde”
“aromatic aldehyde”	the exact phrase “aromatic aldehyde”
benz*	words which begin with “benz”, such as “benzene” or “benzyl”
benz*yl	words that begin with “benz” and end with “yl”, such as “benzyl” or “benzoyl”
benzyl~	words that are close to the word “benzyl”, such as “benzoyl” (i.e., fuzzy search)