Enhanced target cell specificity and uptake of lipid nanoparticles using RNA aptamers and peptides

Scholarly Works

• Song, M.; Bustos, A. H.; Bastue, L.; Mikutavicius, J.; Swiderski, P.; Clemens, K. J.; Habib, N.; Rossi, J.; Astakhova, K. New Transferrin Receptor‐Targeting Conjugate Effectively Delivers DNA to Mouse Brain. Angewandte Chemie 2025. doi:10.1002/ange.202500247
• Song, M.-S.; Bustos, A. H.; Bastue, L.; Mikutavicius, J.; Swiderski, P.; Clemens, K. J.; Habib, N.; Rossi, J.; Astakhova, K. New Transferrin Receptor-Targeting Conjugate Effectively Delivers DNA to Mouse Brain. Angewandte Chemie (International ed. in English) 2025, e202500247. doi:10.1002/anie.202500247
• Luo, C.; Li, Y.; Liu, H.; He, J.; Yang, X.; Zhao, E.; Zi, G.; Liu, L.; Hong, Y.; Wang, H.; Li, T.; Yang, Z.; Wang, R.; Xu, Y.; Peng, B. Intracellular trafficking of lipid nanoparticles is hindered by cholesterol. International journal of pharmaceutics 2025, 671, 125240. doi:10.1016/j.ijpharm.2025.125240
• Garbayo, E.; El Moukhtari, S. H.; Rodríguez-Nogales, C.; Agirre, X.; Rodriguez-Madoz, J. R.; Rodriguez-Marquez, P.; Prósper, F.; Couvreur, P.; Blanco-Prieto, M. J. RNA-loaded nanoparticles for the treatment of hematological cancers. Advanced drug delivery reviews 2024, 214, 115448. doi:10.1016/j.addr.2024.115448
• Vargas, R.; Lizano-Barrantes, C.; Romero, M.; Valencia-Clua, K.; Narváez-Narváez, D. A.; Suñé-Negre, J. M.; Pérez-Lozano, P.; García-Montoya, E.; Martinez-Martinez, N.; Hernández-Munain, C.; Suñé, C.; Suñé-Pou, M. The piper at the gates of brain: A systematic review of surface modification strategies on lipid nanoparticles to overcome the Blood-Brain-Barrier. International journal of pharmaceutics 2024, 665, 124686. doi:10.1016/j.ijpharm.2024.124686
• Davidson, C. G.; Abdulrahman, R.; Punnabhum, P.; Cairns, M.; Rattray, N. J. W.; Capomaccio, R.; Treacher, K.; Perrie, Y.; Rattray, Z. The use of orthogonal analytical approaches to profile lipid nanoparticle physicochemical attributes. Nano Futures 2024, 8, 35001–035001. doi:10.1088/2399-1984/ad70e6
• Wei, Y.; Bao, H.; Wang, L.; Cao, Y.; Liu, Z.; Zhu, X.; Chen, T.; Wu, A.; Li, J. Cell-Penetrating Peptides-Mediated Therapeutic Agents Delivery into the Central Nervous System. ACS Materials Letters 2024, 6, 2239–2258. doi:10.1021/acsmaterialslett.4c00397
• Bu, F.; Song, X.; Zhao, X.; Wang, R.; Xie, Y.; Yu, L.; Yan, X. Advances in micro/nanodrug delivery systems for the treatment of Helicobacter pylori infection: From diagnosis to eradication. Applied Materials Today 2024, 37, 102138. doi:10.1016/j.apmt.2024.102138
• Idris, A.; Shrivastava, S.; Supramaniam, A.; Ray, R. M.; Shevchenko, G.; Acharya, D.; McMillan, N. A. J.; Morris, K. V. Extracellular Vesicles Loaded with Long Antisense RNAs Repress Severe Acute Respiratory Syndrome Coronavirus 2 Infection. Nucleic acid therapeutics 2024, 34, 101–108. doi:10.1089/nat.2023.0078
• Sun, D.; Tan, W.; Zhao, J.; Tian, Y.; Li, S.; Zhang, Z.; Dong, X.; Liu, X.; Liu, N.; Jiao, P.; Ma, J. Delivery of nucleic acid drugs for tumor therapy: Opportunities and challenges. Fundamental Research 2024. doi:10.1016/j.fmre.2023.11.020
• Langel, Ü. CPP Functionalized Nanoparticles. CPP, Cell-Penetrating Peptides; Springer International Publishing, 2023; pp 469–541. doi:10.1007/978-3-031-38731-9_17
• Wang, T.; Sung, T.-C.; Yu, T.; Lin, H.-Y.; Chen, Y.-H.; Zhu, Z.-W.; Gong, J.; Pan, J.; Higuchi, A. Next-generation materials for RNA-lipid nanoparticles: lyophilization and targeted transfection. Journal of materials chemistry. B 2023, 11, 5083–5093. doi:10.1039/d3tb00308f
• Wang, M.-Y.; Zhao, R.; Wang, Y.-L.; Wang, D.-P.; Cao, J.-M. Challenges with the discovery of RNA-based therapeutics for flaviviruses. Expert opinion on drug discovery 2023, 18, 371–383. doi:10.1080/17460441.2023.2195164
• Xiong, R.; Ling, G.; Zhang, Y.; Guan, J.; Zhang, P. Nucleic acid delivery by ionizable nanocarriers for brain disease treatment. Brain‐X 2023, 1. doi:10.1002/brx2.7
• Zhang, Y.-Q.; Guo, R.-R.; Chen, Y.-H.; Li, T.-C.; Du, W.-Z.; Xiang, R.-W.; Guan, J.-B.; Li, Y.-P.; Huang, Y.-Y.; Yu, Z.-Q.; Cai, Y.; Zhang, P.; Ling, G.-X. Ionizable drug delivery systems for efficient and selective gene therapy. Military Medical Research 2023, 10, 9. doi:10.1186/s40779-023-00445-z
• Yang, J.; Luly, K. M.; Green, J. J. Nonviral nanoparticle gene delivery into the CNS for neurological disorders and brain cancer applications. Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology 2022, 15, e1853. doi:10.1002/wnan.1853
• Breier, D.; Peer, D. Genome editing in cancer: Challenges and potential opportunities. Bioactive materials 2022, 21, 394–402. doi:10.1016/j.bioactmat.2022.08.013
• Hald Albertsen, C.; Kulkarni, J. A.; Witzigmann, D.; Lind, M.; Petersson, K.; Simonsen, J. B. The role of lipid components in lipid nanoparticles for vaccines and gene therapy. Advanced drug delivery reviews 2022, 188, 114416. doi:10.1016/j.addr.2022.114416
• Sarode, A.; Fan, Y.; Byrnes, A. E.; Hammel, M.; Hura, G. L.; Fu, Y.; Kou, P.; Hu, C.; Hinz, F. I.; Roberts, J.; Koenig, S. G.; Nagapudi, K.; Hoogenraad, C. C.; Chen, T.; Leung, D.; Yen, C.-W. Predictive high-throughput screening of PEGylated lipids in oligonucleotide-loaded lipid nanoparticles for neuronal gene silencing. Nanoscale advances 2022, 4, 2107–2123. doi:10.1039/d1na00712b
• Ezra Manicum, A.-L.; Sargazi, S.; Razzaq, S.; Kumar, G. V.; Rahdar, A.; Er, S.; Ain, Q. U.; Bilal, M.; Aboudzadeh, M. A. Nano-immunotherapeutic strategies for targeted RNA delivery: Emphasizing the role of monocyte/macrophages as nanovehicles to treat glioblastoma multiforme. Journal of Drug Delivery Science and Technology 2022, 71, 103288. doi:10.1016/j.jddst.2022.103288

Explore citations to this article at