Celebrating the role of chemistry in the success of oligonucleotides as therapeutics

  1. editorImage
  1. Editors: Dr. Pawan Kumar, Takeda Pharmaceutical, San Diego
    Prof. Tom Brown, University of Oxford

In recent years, oligonucleotides have made remarkable strides as future medicines. The potential of oligonucleotides as treatment for previous untreatable conditions has been realized by the recent regulatory approvals of antisense oligonucleotides (inotersen and golodirsen) and small interfering double stranded RNA (patisiran and givosiran). Additionally, significant progress has been made in emerging technologies such as CRISPR-Cas systems. 

Chemistry has played a critical role in the success of therapeutic oligonucleotides. This year mark the approval of first, fully chemically modified small interfering double stranded RNA conjugated to a ligand (N-acetylgalactosamine) by the FDA. This special issue is intended to celebrate the success of chemists and chemistry, and we invite all the researchers in the field of nucleic acids to participate by submitting their novel research work, or sharing their knowledge of the field in the form of review articles.

  • Full Research Paper
  • Published 04 Mar 2021

Beilstein J. Org. Chem. 2021, 17, 622–629, doi:10.3762/bjoc.17.54

  • Full Research Paper
  • Published 29 Mar 2021

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2021, 17, 749–761, doi:10.3762/bjoc.17.65

Enhanced target cell specificity and uptake of lipid nanoparticles using RNA aptamers and peptides

  1. Roslyn M. Ray,
  2. Anders Højgaard Hansen,
  3. Maria Taskova,
  4. Bernhard Jandl,
  5. Jonas Hansen,
  6. Citra Soemardy,
  7. Kevin V. Morris and
  8. Kira Astakhova
  • Full Research Paper
  • Published 26 Apr 2021

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  • Supp. Info

Beilstein J. Org. Chem. 2021, 17, 891–907, doi:10.3762/bjoc.17.75

Beyond ribose and phosphate: Selected nucleic acid modifications for structure–function investigations and therapeutic applications

  1. Christopher Liczner,
  2. Kieran Duke,
  3. Gabrielle Juneau,
  4. Martin Egli and
  5. Christopher J. Wilds
  • Review
  • Published 28 Apr 2021

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Beilstein J. Org. Chem. 2021, 17, 908–931, doi:10.3762/bjoc.17.76

Antiviral therapy in shrimp through plant virus VLP containing VP28 dsRNA against WSSV

  1. Santiago Ramos-Carreño,
  2. Ivone Giffard-Mena,
  3. Jose N. Zamudio-Ocadiz,
  4. Alfredo Nuñez-Rivera,
  5. Ricardo Valencia-Yañez,
  6. Jaime Ruiz-Garcia,
  7. Maria Teresa Viana and
  8. Ruben D. Cadena-Nava
  • Full Research Paper
  • Published 01 Jun 2021

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  • Supp. Info

Beilstein J. Org. Chem. 2021, 17, 1360–1373, doi:10.3762/bjoc.17.95

Double-headed nucleosides: Synthesis and applications

  1. Vineet Verma,
  2. Jyotirmoy Maity,
  3. Vipin K. Maikhuri,
  4. Ritika Sharma,
  5. Himal K. Ganguly and
  6. Ashok K. Prasad
  • Review
  • Published 08 Jun 2021

  • PDF

Beilstein J. Org. Chem. 2021, 17, 1392–1439, doi:10.3762/bjoc.17.98

Chemical approaches to discover the full potential of peptide nucleic acids in biomedical applications

  1. Nikita Brodyagin,
  2. Martins Katkevics,
  3. Venubabu Kotikam,
  4. Christopher A. Ryan and
  5. Eriks Rozners
  • Review
  • Published 19 Jul 2021

  • PDF

Beilstein J. Org. Chem. 2021, 17, 1641–1688, doi:10.3762/bjoc.17.116

  • Review
  • Published 29 Jul 2021

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Beilstein J. Org. Chem. 2021, 17, 1828–1848, doi:10.3762/bjoc.17.125

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