Synthesis of functionalized imidazo[4,5-e]thiazolo[3,2-b]triazines by condensation of imidazo[4,5-e]triazinethiones with DMAD or DEAD and rearrangement to imidazo[4,5-e]thiazolo[2,3-c]triazines

Scholarly Works

• Izmest'ev, A. N.; Romanov, N. A.; Streltsov, A. A.; Kolotyrkina, N. G.; Kravchenko, A. N.; Gazieva, G. A. Application of 1,3-disubstituted thioureas as a key synthons for the synthesis of novel 5,7-disubstituted perhydroimidazo[4,5-e][1,2,4]triazinethiones. Tetrahedron 2025, 187, 134905. doi:10.1016/j.tet.2025.134905
• Streltsov, A. А.; Izmest'ev, A. N.; Kolotyrkina, N. G.; Kravchenko, A. N.; Gazieva, G. A. Metal-free CH-functionalization of trisubstituted alkenes with pyridinium ylides: Development of the concept. Synthetic Communications 2025, 55, 1178–1184. doi:10.1080/00397911.2025.2531537
• Izmest'ev, A. N.; Baranov, V. V.; Kolotyrkina, N. G.; Kravchenko, A. N.; Gazieva, G. A. Regioselective Synthesis of Imidazo[4,5‐e][1,3]Thiazino[3,2‐b][1,2,4]Triazines as New Heterocyclic System Derivatives. Journal of Heterocyclic Chemistry 2024, 62, 58–64. doi:10.1002/jhet.4925
• Streltsov, A. A.; Izmest'ev, A. N.; Strelenko, Y. A.; Kravchenko, A. N.; Gazieva, G. A. Synthesis of new functionalized thiazolidin-4-ones by the condensation of thioureas with dialkyl acetylenedicarboxylates. Mendeleev Communications 2024, 34, 563–565. doi:10.1016/j.mencom.2024.06.031
• Galochkin, A. A.; Astakhova, M. K.; Alekseenko, A. L.; Baranov, V. V.; Strelenko, Y. A.; Popkov, S. V.; Kravchenko, A. N. Synthesis of the First Representatives of new 3,3a‐Dihydro‐1 H ‐Imidazo[4′,5′:4,5]Imidazo[2,1‐ b ]thia(selena)zole Heterocyclic Systems with Fungicidal Activity. ChemistrySelect 2024, 9. doi:10.1002/slct.202400624
• Halim, A. N. A.; Zikri, N. A. S.; Ngaini, Z.; Zamakshshari, N. H.; Wei, Y. K.; Diosing, D. N. Synthesis In Silico and ADMET Profile of Triazinethione Derivatives for Their Potential as Anti-Inflammatory Agents. Russian Journal of General Chemistry 2023, 93, 2889–2899. doi:10.1134/s1070363223110208
• Izmest Ev, A. N.; Vinogradov, D. B.; Kravchenko, A. N.; Kolotyrkina, N. G.; Gazieva, G. A. Diastereoselective Synthesis of Dispiro[Imidazothiazolotriazine-Pyrrolidin-Oxindoles] and Their Isomerization Pathways in Basic Medium. International journal of molecular sciences 2023, 24, 16359. doi:10.3390/ijms242216359
• Vinogradov, D. B.; Izmest'ev, A. N.; Kravchenko, A. N.; Kolotyrkina, N. G.; Gazieva, G. A. Regioselective synthesis of new imidazo[4,5‐e][1,3]thiazino[2,3‐c][1,2,4]triazines via reaction of imidazo[4,5‐e][1,2,4]triazinethiones with ethyl phenylpropiolate. Journal of Heterocyclic Chemistry 2023, 61, 137–145. doi:10.1002/jhet.4753
• Vinogradov, D. B.; Izmest'ev, A. N.; Kravchenko, A. N.; Strelenko, Y. A.; Gazieva, G. A. Synthesis of imidazo[4,5-e][1,3]thiazino[2,3-c][1,2,4]triazines via a base-induced rearrangement of functionalized imidazo[4,5-e]thiazolo[2,3-c][1,2,4]triazines. Beilstein journal of organic chemistry 2023, 19, 1047–1054. doi:10.3762/bjoc.19.80
• Vinogradova, E. E.; Kravchenko, A. N.; Gazieva, G. A. One‐pot regioselective synthesis of new imidazo[4,5‐e]thiazolo[3,2‐b][1,2,4]triazines by reaction of imidazotriazines with propargyl bromide. Journal of Heterocyclic Chemistry 2023, 60, 1609–1618. doi:10.1002/jhet.4706
• Izmest'ev, A. N.; Karnoukhova, V. A.; Larin, A. A.; Kravchenko, A. N.; Fershtat, L. L.; Gazieva, G. A. Synthesis, Structure and Stereochemistry of Dispirocompounds Based on Imidazothiazolotriazine and Pyrrolidineoxindole. International journal of molecular sciences 2022, 23, 13820. doi:10.3390/ijms232213820
• Izmest'ev, A. N.; Motornov, V. A.; Vinogradov, D. B.; Ioffe, S. L.; Kravchenko, A. N.; Gazieva, G. A. Tandem Michael addition/elimination – novel reactivity of pyridinium ylides in reaction with electron-deficient alkenes. Organic Chemistry Frontiers 2022, 9, 4998–5004. doi:10.1039/d2qo00911k
• Izmest'ev, A. N.; Anikina, L. V.; Zanin, I. E.; Kolotyrkina, N. G.; Izmalkova, E. S.; Kravchenko, A. N.; Gazieva, G. A. Design, synthesis andin vitroevaluation of the hybrids of oxindolylidene and imidazothiazolotriazine as efficient antiproliferative agents. New Journal of Chemistry 2022, 46, 11632–11647. doi:10.1039/d2nj01454h

Explore citations to this article at