Supporting Information
| Supporting Information File 1: High-quality version of the phylogenetic tree shown in Figure 2 with tip labels. | ||
| Format: PDF | Size: 519.0 KB | Download |
Cite the Following Article
Cytochrome P450 monooxygenase-mediated tailoring of triterpenoids and steroids in plants
Karan Malhotra and Jakob Franke
Beilstein J. Org. Chem. 2022, 18, 1289–1310.
https://doi.org/10.3762/bjoc.18.135
How to Cite
Malhotra, K.; Franke, J. Beilstein J. Org. Chem. 2022, 18, 1289–1310. doi:10.3762/bjoc.18.135
Download Citation
Citation data can be downloaded as file using the "Download" button or used for copy/paste from the text window
below.
Citation data in RIS format can be imported by all major citation management software, including EndNote,
ProCite, RefWorks, and Zotero.
Presentation Graphic
| Picture with graphical abstract, title and authors for social media postings and presentations. | ||
| Format: PNG | Size: 11.3 MB | Download |
Citations to This Article
Up to 20 of the most recent references are displayed here.
Scholarly Works
- Rutz, A.; Probst, D.; Aguilar, C.; Akiyama, D. Y.; Alberti, F.; Augustijn, H. E.; Avalon, N. E.; Beemelmanns, C.; Barbieri, H. B.; Biermann, F.; Bridge, A. J.; Girón, E. C.; Cox, R.; Crüsemann, M.; D'Agostino, P. M.; Feuermann, M.; Gerke, J.; García, K. G.; Holme, J. E.; Hwang, J.-Y.; Iacovelli, R.; Jeronimo Barbosa, J. C.; Kaur, N.; Klapper, M.; Köhler, A. M.; Korenskaia, A.; Kubach, N.; Lee, B. T.; Loureiro, C.; Mantri, S.; Narula, S.; Meijer, D.; Navarro-Muñoz, J. C.; Nguyen, G.-S.; Paliyal, S.; Panghal, M.; Rao, L.; Sieber, S.; Sokolova, N.; Sowa, S. T.; Szenei, J.; Terlouw, B. R.; Weddeling, H. G.; Yu, J.; Ziemert, N.; Weber, T.; Blin, K.; van der Hooft, J. J. J.; Medema, M. H.; Zdouc, M. M. MITE: the Minimum Information about a Tailoring Enzyme database for capturing specialized metabolite biosynthesis. Nucleic acids research 2025. doi:10.1093/nar/gkaf969
- Hakim, S. E.; Choudhary, N.; Malhotra, K.; Peng, J.; Bültemeier, A.; Arafa, A.; Friedhoff, R.; Bauer, M.; Eikenberg, J.; Witte, C.-P.; Herde, M.; Heretsch, P.; Pucker, B.; Franke, J. Phylogenomics and metabolic engineering reveal a conserved gene cluster in Solanaceae plants for withanolide biosynthesis. Nature communications 2025, 16, 6367. doi:10.1038/s41467-025-61686-1
- Xu, X.; Tang, R.; Liu, L.; Zhang, Q.; Xiong, H.; Mei, Z.; Liu, Y. Comparative transcriptome-metabolome study reveals the functions of pentacyclic triterpene synthase and flavonoid glycosyltransferases in Entada phaseoloides. International journal of biological macromolecules 2025, 318, 145278. doi:10.1016/j.ijbiomac.2025.145278
- Phyon, J.-M.; Zheng, D.; Cao, L.; Wang, X.; Ri, H.-C.; An, Z.; Yin, X.; Kim, C.-M.; Mun, N.-H.; Wu, H.; Zhang, P.; Shen, H.; Zhang, H.; Li, Y.; Wang, Y. Exploring oxidosqualene cyclases and cytochrome P450s from Aralia elata for the synthesis of diverse pentacyclic triterpene sapogenins in Nicotiana benthamiana. Plant physiology and biochemistry : PPB 2025, 226, 110047. doi:10.1016/j.plaphy.2025.110047
- Meng, Z.; Dong, M.; Xiao, C.; Li, Y.; Zhang, Y.; Cui, J.; Wang, S.; Li, P.; Baleev, D.; Zhan, Y.; Yin, J. Screening CYP450 genes from Gleditsia japonica Miq. and identifying CYP710A157 and CYP71D752 functions in the catalysis of echinocystic acid and betulin. Physiologia plantarum 2025, 177, e70176. doi:10.1111/ppl.70176
- Li, R.; Guo, S.; Wang, D.; Yang, T.; Li, W.; Wang, J.; Huang, L.; Zhang, X.; Dai, Z. Elucidation of the plant progesterone biosynthetic pathway and its application in a yeast cell factory. Metabolic engineering 2025, 90, 197–208. doi:10.1016/j.ymben.2025.03.016
- Hakim, S. E.; Liu, S.; Herzog, R.; Arafa, A.; de Vries, J.; Dräger, G.; Franke, J. Expansion of the Stereochemical Space of Triterpenes by Mining Noncanonical Oxidosqualene Cyclases Across the Diversity of Green Plants. Journal of the American Chemical Society 2025, 147, 10320–10330. doi:10.1021/jacs.4c16956
- Zong, J.-F.; Guo, X.-X.; Zou, K.-K.; Cui, C.-J.; Hu, Z.-H.; Hou, R.-Y. Isolation and identification of triterpenoid saponins with antiproliferative and hemolytic activities from Camellia oleifera Abel seeds. Phytochemistry 2025, 235, 114476. doi:10.1016/j.phytochem.2025.114476
- Mendoza Lara, D. F.; Hernández-Caballero, M. E.; Terán, J. L.; Ramírez, J. S.; Carrasco-Carballo, A. Anticancer Activities of Natural and Synthetic Steroids: A Review. ACS omega 2025, 10, 7493–7509. doi:10.1021/acsomega.4c08577
- Zeng, W.; Li, H.; Liu, S.; Luo, Z.; Chen, J.; Zhou, J. Biosynthesis and bioactivities of triterpenoids from Centella asiatica: Challenges and opportunities. Biotechnology advances 2025, 80, 108541. doi:10.1016/j.biotechadv.2025.108541
- Shirke, H. A.; Darshetkar, A. M.; Naikawadi, V. B.; Kavi Kishor, P. B.; Nikam, T. D.; Barvkar, V. T. Genomics of sterols biosynthesis in plants: Current status and future prospects. Plant science : an international journal of experimental plant biology 2025, 353, 112426. doi:10.1016/j.plantsci.2025.112426
- Liu, S.-J.; Liu, Z.; Shao, B.-Y.; Li, T.; Zhu, X.; Wang, R.; Shi, L.; Xu, S.; Van de Peer, Y.; Xue, J.-Y. Deciphering the biosynthetic pathway of triterpene saponins in Prunella vulgaris. The Plant journal : for cell and molecular biology 2025, 121, e17220. doi:10.1111/tpj.17220
- Yang, Y.; Wang, H.; Wu, Z.; Wang, X.; Tong, Y.; Huang, W.; Liu, X.; Zhao, H.; Hu, Y.; Zhang, X. Identification and Engineering of UDP-rhamnosyltransferase from Trillium tschonoskii for Heterologous Biosynthesis of Polyphyllin II in Engineered Yeast. Cold Spring Harbor Laboratory 2025. doi:10.1101/2025.01.26.634900
- Gutiérrez-Rebolledo, G. A.; Pérez-González, M. Z.; Sánchez-Ramos, M.; Cruz-Sosa, F. In vitro plant cultures as a viable biotechnological tool for the biosynthesis of steroidal hormones of clinical interest. Whole Cell Biocatalysis; Elsevier, 2025; pp 203–251. doi:10.1016/b978-0-443-23998-4.00010-5
- Yang, T.; Chen, J.; Shi, N.; Fan, B.; Yi, R.; Liang, S.; Ji, A.; Liu, Z.; Li, C.; Wang, Q.; Duan, L. Discovery and Functional Identification of 2,3-Oxidosqualene Cyclases and Cytochrome P450s in Triterpenoid Metabolic Pathways of Actinidia eriantha. Journal of agricultural and food chemistry 2024, 72, 27902–27911. doi:10.1021/acs.jafc.4c06937
- Luo, X.; Ye, Z.; Shi, X.; Hu, Z.; Shen, J.; You, L.; Huang, P.; Wang, G.; Zheng, L.; Li, C.; Zhang, Y. Comparative transcriptomic analysis provides insights into the regulation of root-specific saponin production in Panax japonicus. Scientific reports 2024, 14, 27572. doi:10.1038/s41598-024-78720-9
- Hakim, S. E.; Choudhary, N.; Malhotra, K.; Peng, J.; Arafa, A.; Bültemeier, A.; Friedhoff, R.; Bauer, M.; Witte, C.-P.; Herde, M.; Heretsch, P.; Pucker, B.; Franke, J. Phylogenomics and metabolic engineering reveal a conserved gene cluster in Solanaceae plants for withanolide biosynthesis. Cold Spring Harbor Laboratory 2024. doi:10.1101/2024.09.27.614867
- Tamura, K.; Chiba, H.; Bono, H. Triterpene RDF: Developing a database of plant enzymes and transcription factors involved in triterpene biosynthesis using the Resource Description Framework. Plant biotechnology (Tokyo, Japan) 2024, 41, 303–308. doi:10.5511/plantbiotechnology.24.0312c
- Winegar, P. H.; Hudson, G. A.; Dell, L. B.; Astolfi, M. C. T.; Reed, J.; Payet, R. D.; Ombredane, H. C. J.; Iavarone, A. T.; Chen, Y.; Gin, J. W.; Petzold, C. J.; Osbourn, A. E.; Keasling, J. D. Verazine biosynthesis from simple sugars in engineered Saccharomyces cerevisiae. Metabolic engineering 2024, 85, 145–158. doi:10.1016/j.ymben.2024.07.011
- Peng, Y.; Tang, Y.; Li, D.; Ye, J. The Growth-Promoting and Colonization of the Pine Endophytic Pseudomonas abietaniphila for Pine Wilt Disease Control. Microorganisms 2024, 12, 1089. doi:10.3390/microorganisms12061089