Enzymes in biosynthesis

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Editor: Prof. Jeroen S. Dickschat
University of Bonn
 
Biosynthetic pathways towards natural products usually depend on highly specialized enzymes. This thematic issue calls for manuscripts covering various aspects of biosynthetic enzymes, including (but not limited to) functional characterization, enzyme mechanistic studies, structural work, and mutational investigations. Studies covering the application of enzymes in total synthesis or in the transformation of nonnatural substrate analogs are also welcome.
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Enzymes in biosynthesis

  • Jeroen S. Dickschat

Beilstein J. Org. Chem. 2022, 18, 1131–1132, doi:10.3762/bjoc.18.116

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Editorial
Published 30 Aug 2022

Structural basis for endoperoxide-forming oxygenases

  • Takahiro Mori and
  • Ikuro Abe

Beilstein J. Org. Chem. 2022, 18, 707–721, doi:10.3762/bjoc.18.71

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Review
Published 21 Jun 2022

Identification of the new prenyltransferase Ubi-297 from marine bacteria and elucidation of its substrate specificity

  • Jamshid Amiri Moghaddam,
  • Huijuan Guo,
  • Karsten Willing,
  • Thomas Wichard and
  • Christine Beemelmanns

Beilstein J. Org. Chem. 2022, 18, 722–731, doi:10.3762/bjoc.18.72

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Published 22 Jun 2022

The stereochemical course of 2-methylisoborneol biosynthesis

  • Binbin Gu,
  • Anwei Hou and
  • Jeroen S. Dickschat

Beilstein J. Org. Chem. 2022, 18, 818–824, doi:10.3762/bjoc.18.82

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Letter
Published 08 Jul 2022

Efficient production of clerodane and ent-kaurane diterpenes through truncated artificial pathways in Escherichia coli

  • Fang-Ru Li,
  • Xiaoxu Lin,
  • Qian Yang,
  • Ning-Hua Tan and
  • Liao-Bin Dong

Beilstein J. Org. Chem. 2022, 18, 881–888, doi:10.3762/bjoc.18.89

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Published 21 Jul 2022

Anti-inflammatory aromadendrane- and cadinane-type sesquiterpenoids from the South China Sea sponge Acanthella cavernosa

  • Shou-Mao Shen,
  • Qing Yang,
  • Yi Zang,
  • Jia Li,
  • Xueting Liu and
  • Yue-Wei Guo

Beilstein J. Org. Chem. 2022, 18, 916–925, doi:10.3762/bjoc.18.91

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Published 25 Jul 2022

Understanding the competing pathways leading to hydropyrene and isoelisabethatriene

  • Shani Zev,
  • Marion Ringel,
  • Ronja Driller,
  • Bernhard Loll,
  • Thomas Brück and
  • Dan T. Major

Beilstein J. Org. Chem. 2022, 18, 972–978, doi:10.3762/bjoc.18.97

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Published 04 Aug 2022

Isolation and biosynthesis of daturamycins from Streptomyces sp. KIB-H1544

  • Yin Chen,
  • Jinqiu Ren,
  • Ruimin Yang,
  • Jie Li,
  • Sheng-Xiong Huang and
  • Yijun Yan

Beilstein J. Org. Chem. 2022, 18, 1009–1016, doi:10.3762/bjoc.18.101

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Published 09 Aug 2022

New azodyrecins identified by a genome mining-directed reactivity-based screening

  • Atina Rizkiya Choirunnisa,
  • Kuga Arima,
  • Yo Abe,
  • Noritaka Kagaya,
  • Kei Kudo,
  • Hikaru Suenaga,
  • Junko Hashimoto,
  • Manabu Fujie,
  • Noriyuki Satoh,
  • Kazuo Shin-ya,
  • Kenichi Matsuda and
  • Toshiyuki Wakimoto

Beilstein J. Org. Chem. 2022, 18, 1017–1025, doi:10.3762/bjoc.18.102

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Published 10 Aug 2022

A Streptomyces P450 enzyme dimerizes isoflavones from plants

  • Run-Zhou Liu,
  • Shanchong Chen and
  • Lihan Zhang

Beilstein J. Org. Chem. 2022, 18, 1107–1115, doi:10.3762/bjoc.18.113

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Published 26 Aug 2022

Make or break: the thermodynamic equilibrium of polyphosphate kinase-catalysed reactions

  • Michael Keppler,
  • Sandra Moser,
  • Henning J. Jessen,
  • Christoph Held and
  • Jennifer N. Andexer

Beilstein J. Org. Chem. 2022, 18, 1278–1288, doi:10.3762/bjoc.18.134

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Published 20 Sep 2022

Cytochrome P450 monooxygenase-mediated tailoring of triterpenoids and steroids in plants

  • Karan Malhotra and
  • Jakob Franke

Beilstein J. Org. Chem. 2022, 18, 1289–1310, doi:10.3762/bjoc.18.135

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Published 21 Sep 2022

Characterization of a new fusicoccane-type diterpene synthase and an associated P450 enzyme

  • Jia-Hua Huang,
  • Jian-Ming Lv,
  • Liang-Yan Xiao,
  • Qian Xu,
  • Fu-Long Lin,
  • Gao-Qian Wang,
  • Guo-Dong Chen,
  • Sheng-Ying Qin,
  • Dan Hu and
  • Hao Gao

Beilstein J. Org. Chem. 2022, 18, 1396–1402, doi:10.3762/bjoc.18.144

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Published 05 Oct 2022

Navigating and expanding the roadmap of natural product genome mining tools

  • Friederike Biermann,
  • Sebastian L. Wenski and
  • Eric J. N. Helfrich

Beilstein J. Org. Chem. 2022, 18, 1656–1671, doi:10.3762/bjoc.18.178

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Perspective
Published 06 Dec 2022
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