Inline purification in continuous flow synthesis – opportunities and challenges

Scholarly Works

• Chen, J.; Zou, Y.; Liao, L.; Yang, B.; Xing, D.; Zhou, J.; Qian, X.; Liu, Y.; He, H.; Gao, S. Trends and Challenges in Multistep Continuous Flow Synthesis. JACS Au 2026, 6, 731–755. doi:10.1021/jacsau.5c01611
• Jamieson, P.; Bannon, R.; Cronly, D.; Smyth, M.; Wharry, S.; Moody, T. S.; Lennon, G.; Baumann, M. The Impact of Continuous Flow Technology and Collaboration between Academia and Industry. JACS Au 2026, 6, 691–719. doi:10.1021/jacsau.5c01617
• Gazis, T. A.; Teixeira, R. I.; Volpin, G.; Yewale, A.; Ince, M. C.; Ford, M. J.; Harmsen, J.; Uboldi, M.; Melocchi, A.; Sponchioni, M.; Aramini, A.; Luisi, R.; Benyahia, B.; Vilé, G. Towards greener-by-design fine chemicals. Part 2: technological frontiers. Chemical Society reviews 2026, 55, 675–713. doi:10.1039/d5cs00930h
• Razali, M. P. H.; Ilyas, R.; Yasim-Anuar, T. A. T.; Husin, H.; Hawanis, H.; Razali, N. Nanocellulose from oil palm biomass: A pathway to sustainable high-performance paper and packaging materials. Journal of Environmental Chemical Engineering 2026, 14, 121311. doi:10.1016/j.jece.2026.121311
• Masuda, K.; Yamamoto, T.; Kobayashi, K.; Sano, H.; Saito, I.; Nagaki, A.; Yada, A. Crystallization-Based Approach To Continuous Manufacturing: A Case Study of Acetaminophen Production. Organic Process Research & Development 2026, 30, 312–320. doi:10.1021/acs.oprd.5c00332
• Khositanon, C.; Thakhiew, P.; Chinwanitcharoen, C.; Hiromori, K.; Weeranoppanant, N. Opportunities for automation in continuous dynamic flow separation. Reaction Chemistry & Engineering 2025, 10, 1978–1988. doi:10.1039/d5re00215j
• Raby-Buck, S. E.; Devlin, J.; Gupta, P.; Battilocchio, C.; Baumann, M.; Polyzos, A.; Slater, A. G.; Browne, D. L. Continuous flow chemistry for molecular synthesis. Nature Reviews Methods Primers 2025, 5. doi:10.1038/s43586-025-00414-x
• Crawford, R.; Baumann, M. Continuous Flow Technology Enabling Photochemistry. Advanced Synthesis & Catalysis 2025, 367. doi:10.1002/adsc.202500133
• Rowley, B. M.; Thompson, L. A.; Power, L. A.; Daglish, J.; Parks, E.; Birbeck, J.; Marsden, S.; Kapur, N.; Blacker, A. J. Integrating continuous flow reaction and work-up: chiral amine resolution, separation and purification using a novel coalescing filter system. Reaction chemistry & engineering 2025, 10, 392–397. doi:10.1039/d4re00442f
• O'Hanlon, D.; Davin, S.; Glennon, B.; Baumann, M. Metal-free [2+2]-photocycloaddition of unactivated alkenes enabled by continuous flow processing. Chemical communications (Cambridge, England) 2025, 61, 1403–1406. doi:10.1039/d4cc06000h
• Ivanova, M.; Poisson, T.; Jubault, P.; Chausset-Boissarie, L.; Legros, J. Organic Synthesis in Flow. Comprehensive Organic Synthesis; Elsevier, 2025; pp 53–86. doi:10.1016/b978-0-323-96025-0.00046-6
• Takasuka, S.; Ito, S.; Oikawa, S.; Harashima, Y.; Takayama, T.; Nag, A.; Wakiuchi, A.; Ando, T.; Sugawara, T.; Hatanaka, M.; Miyao, T.; Matsubara, T.; Ohnishi, Y.-Y.; Ajiro, H.; Fujii, M. Bayesian optimization of radical polymerization reactions in a flow synthesis system. Science and Technology of Advanced Materials: Methods 2024, 4. doi:10.1080/27660400.2024.2425178
• Crawford, R.; Ortin, Y.; Twamley, B.; Baumann, M. Direct Photochemical Synthesis of Substituted Benzo[b]fluorenes. Organic letters 2024, 26, 10364–10368. doi:10.1021/acs.orglett.4c03978
• Kobayashi, K.; Matsuzawa, J.; Kawanami, H.; Koumura, N. Continuous-inline extraction of polar co-solvent during sequential flow reactions. Reaction Chemistry & Engineering 2024, 9, 3116–3121. doi:10.1039/d4re00276h
• Bonner, A.; Baumann, M. Continuous flow synthesis of the antiviral drug tecovirimat and related sp3-rich scaffolds. Organic & biomolecular chemistry 2024, 22, 8323–8327. doi:10.1039/d4ob01379d
• Alfano, A. I.; Smyth, M.; Wharry, S.; Moody, T. S.; Nuño, M.; Butters, C.; Baumann, M. Multiphase photochemistry in flow mode via an integrated continuous stirred tank reactor (CSTR) approach. Chemical communications (Cambridge, England) 2024, 60, 7037–7040. doi:10.1039/d4cc02477j
• Bonner, A.; Naik, P.; Crawford, R.; Baumann, M. Recent advances exploiting reactive intermediates generated via continuous flow chemistry. Current Opinion in Green and Sustainable Chemistry 2024, 47, 100907. doi:10.1016/j.cogsc.2024.100907
• Ichitsuka, T.; Sato, M.; Miura, S.; Makino, T.; Ishizaka, T. Telescoped Two-Step Continuous-Flow Synthesis of Vanillin. ACS Sustainable Chemistry & Engineering 2023, 11, 16322–16329. doi:10.1021/acssuschemeng.3c05168
• Chaichol, P.; Weeranoppanant, N. Advances in in situ and in-line liquid–liquid extraction for bioprocess intensification. Reaction Chemistry & Engineering 2023, 8, 2387–2402. doi:10.1039/d3re00266g
• Naik, P.; García-Lacuna, J.; O'Neill, P.; Baumann, M. Continuous Flow Oxidation of Alcohols Using TEMPO/NaOCl for the Selective and Scalable Synthesis of Aldehydes. Organic process research & development 2023, 28, 1587–1596. doi:10.1021/acs.oprd.3c00237

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