Chemistry of polyhalogenated nitrobutadienes, 17: Efficient synthesis of persubstituted chloroquinolinyl-1H-pyrazoles and evaluation of their antimalarial, anti-SARS-CoV-2, antibacterial, and cytotoxic activities

Viktor A. Zapol’skii, Isabell Berneburg, Ursula Bilitewski, Melissa Dillenberger, Katja Becker, Stefan Jungwirth, Aditya Shekhar, Bastian Krueger and Dieter E. Kaufmann

Beilstein J. Org. Chem. 2022, 18, 524–532. https://doi.org/10.3762/bjoc.18.54

Supporting Information

Supporting Information File 1: Experimental procedures, characterization data (1H, 13C, 14N, 15N NMR, IR, MS and HRMS), copies of spectra, and detailed procedures of biological assays.
Format: PDF Size: 6.8 MB Download

References

Article Citation
Download RIS (Reference Manager) Download BIB (BIBTEX)
Cited References
Download RIS (Reference Manager) Download BIB (BIBTEX)

Presentation Graphic

Picture with graphical abstract, title and authors for social media postings and presentations.

Format: PNG Size: 8.9 MB Download
Back To Article

Latest Articles

CuAAC-inspired synthesis of 1,2,3-triazole-bridged porphyrin conjugates: an overview

  1. Dileep Kumar Singh
  • Review
  • Published 22 Mar 2023
Graphical Abstract

Beilstein J. Org. Chem. 2023, 19, 349–379, doi:10.3762/bjoc.19.29

Group 13 exchange and transborylation in catalysis

  1. Dominic R. Willcox and
  2. Stephen P. Thomas
  • Review
  • Published 21 Mar 2023
Graphical Abstract

Beilstein J. Org. Chem. 2023, 19, 325–348, doi:10.3762/bjoc.19.28

Synthesis and reactivity of azole-based iodazinium salts

  1. Thomas J. Kuczmera,
  2. Annalena Dietz,
  3. Andreas Boelke and
  4. Boris J. Nachtsheim
  • Full Research Paper
  • Published 16 Mar 2023
Graphical Abstract

Beilstein J. Org. Chem. 2023, 19, 317–324, doi:10.3762/bjoc.19.27

Recommendations for performing measurements of apparent equilibrium constants of enzyme-catalyzed reactions and for reporting the results of these measurements

  1. Robert N. Goldberg,
  2. Robert T. Giessmann,
  3. Peter J. Halling,
  4. Carsten Kettner and
  5. Hans V. Westerhoff
  • Perspective
  • Published 15 Mar 2023
Graphical Abstract

Beilstein J. Org. Chem. 2023, 19, 303–316, doi:10.3762/bjoc.19.26

Continuous flow synthesis of 6-monoamino-6-monodeoxy-β-cyclodextrin

  1. János Máté Orosz,
  2. Dóra Ujj,
  3. Petr Kasal,
  4. Gábor Benkovics and
  5. Erika Bálint
  • Full Research Paper
  • Published 09 Mar 2023
Graphical Abstract

Beilstein J. Org. Chem. 2023, 19, 294–302, doi:10.3762/bjoc.19.25

Synthesis, α-mannosidase inhibition studies and molecular modeling of 1,4-imino-ᴅ-lyxitols and their C-5-altered N-arylalkyl derivatives

  1. Martin Kalník,
  2. Sergej Šesták,
  3. Juraj Kóňa,
  4. Maroš Bella and
  5. Monika Poláková
  • Full Research Paper
  • Published 06 Mar 2023
Graphical Abstract

Beilstein J. Org. Chem. 2023, 19, 282–293, doi:10.3762/bjoc.19.24

Strategies to access the [5-8] bicyclic core encountered in the sesquiterpene, diterpene and sesterterpene series

  1. Cécile Alleman,
  2. Charlène Gadais,
  3. Laurent Legentil and
  4. François-Hugues Porée
  • Review
  • Published 03 Mar 2023
Graphical Abstract

Beilstein J. Org. Chem. 2023, 19, 245–281, doi:10.3762/bjoc.19.23

An efficient metal-free and catalyst-free C–S/C–O bond-formation strategy: synthesis of pyrazole-conjugated thioamides and amides

  1. Shubham Sharma,
  2. Dharmender Singh,
  3. Sunit Kumar,
  4. Vaishali,
  5. Rahul Jamra,
  6. Naveen Banyal,
  7. Deepika,
  8. Chandi C. Malakar and
  9. Virender Singh
  • Full Research Paper
  • Published 02 Mar 2023
Graphical Abstract

Beilstein J. Org. Chem. 2023, 19, 231–244, doi:10.3762/bjoc.19.22

Investigation of cationic ring-opening polymerization of 2-oxazolines in the “green” solvent dihydrolevoglucosenone

  1. Solomiia Borova and
  2. Robert Luxenhofer
  • Full Research Paper
  • Published 28 Feb 2023
Graphical Abstract

Beilstein J. Org. Chem. 2023, 19, 217–230, doi:10.3762/bjoc.19.21

Friedel–Crafts acylation of benzene derivatives in tunable aryl alkyl ionic liquids (TAAILs)

  1. Swantje Lerch,
  2. Stefan Fritsch and
  3. Thomas Strassner
  • Full Research Paper
  • Published 23 Feb 2023
Graphical Abstract

Beilstein J. Org. Chem. 2023, 19, 212–216, doi:10.3762/bjoc.19.20

Latest Articles

Latest Thematic Issues

Enzymes in biosynthesis

Jeroen S. Dickschat

2022 Show Issue

Molecular and macromolecular electrochemistry: synthesis, mechanism, and redox properties

Shinsuke Inagi and Mahito Atobe

2022 Show Issue

Cyclodextrins as building blocks for new materials

Sophie Fourmentin and Miriana Kfoury

New Call Show Issue

Total synthesis: an enabling science

Bastien Nay

New Show Issue

Mechanochemistry III

José G. Hernández and Lars Borchardt

2022 Show Issue

Platform and enabling technologies in organic synthesis

Philipp Heretsch and Andreas Kirschning

2021 Show Issue

Organophosphorus chemistry: from model to application

György Keglevich

2021 Show Issue

Organic TADF materials design

Eli Zysman-Colman

2021 Show Issue

Earth-abundant 3d metal catalysis

Lutz Ackermann

2021 Show Issue
Browse all Thematic Issues

Other Beilstein-Institut Open Science Activities

Logo
Logo
Logo
Logo

Keep Informed

RSS Feed

Subscribe to our Latest Articles RSS Feed.

Subscribe

Follow the Beilstein-Institut

LinkedIn

Twitter: @BeilsteinInst