Combining the best of both worlds: radical-based divergent total synthesis

Scholarly Works

• Lü, J.-F.; Wu, J.-F.; Ye, J.-L.; Huang, P.-Q. Further elaboration of the stereodivergent approach to chaetominine-type alkaloids: synthesis of the reported structures of aspera chaetominines A and B and revised structure of aspera chaetominine B. Beilstein journal of organic chemistry 2025, 21, 2072–2081. doi:10.3762/bjoc.21.162
• Yu, H.; Kim, H.; Lee, D. Stereocontrolled Divergent Total Syntheses of (+)-7-Deoxypancratistatin, (+)-7-Deoxy-trans-dihydronarciclasine, and (+)-Lycoricidine via Cyclic Boronic Ester-Mediated Diastereoselective Alkenylation. Organic letters 2025, 27, 11515–11520. doi:10.1021/acs.orglett.5c03530
• Wu, J.; Bao, J.; Deng, J.; Tian, H.; Gui, J. Concise Syntheses of Harziane Diterpenoids by Merging Local Desymmetrization and Radical Retrosynthesis. Journal of the American Chemical Society 2025, 147, 30599–30605. doi:10.1021/jacs.5c09579
• Xiong, Y.; Liu, J.; Ma, Y.; Jiang, Z.; Ge, Y.; Tang, J. Bis‐Tetrasubstituted Centers Forming Formal [3 + 3] Cycloaddition Reaction via Bifunctional Organocatalysis: Synthesis of Spiro‐Oxindoles. European Journal of Organic Chemistry 2025, 28. doi:10.1002/ejoc.202500324
• Sheng, X.-X.; Qiu, C.-Y.; Wang, L.-N.; Du, Y.-J.; Tang, L.-N.; Chen, J.-M.; Liu, G.-Y.; Yang, S.; Zheng, P.-F.; Chen, M. Transition-Metal-Free Radical Relay Cascade Annulation of Amides: Access to Antitumor Active Benzo[b]azepine and Oxindole Derivatives. Chemistry (Weinheim an der Bergstrasse, Germany) 2024, 30, e202402402. doi:10.1002/chem.202402402
• Brunelli, F.; Quartieri, F.; Miletto, I.; Pulici, M.; Papeo, G.; Tron, G. C. Visible Light Promoted Site-Specific Functionalization of α-Acyloxy Carboxamides: Unlocking a Forbidden Chemical Space in the Passerini Reaction. Chemistry (Weinheim an der Bergstrasse, Germany) 2024, 30, e202402175. doi:10.1002/chem.202402175
• Yamada, Y.; Yoshinaga, R.; Matsui, Y.; Nagatomo, M.; Fujino, H.; Inoue, M. Et3Al/Light-Promoted Radical-Polar Crossover Reactions of α-Alkoxyacyl Tellurides. The Journal of organic chemistry 2024, 89, 11701–11706. doi:10.1021/acs.joc.4c01445
• Fujino, H.; Inoue, M. Convergent Total Synthesis of Hikizimycin: Development of New Radical-Based and Protective Group Strategies. Modern Natural Product Synthesis; Springer Nature Singapore, 2024; pp 127–144. doi:10.1007/978-981-97-1619-7_6
• Azpilcueta-Nicolas, C. R.; Lumb, J.-P. Mechanisms for radical reactions initiating from N-hydroxyphthalimide esters. Beilstein journal of organic chemistry 2024, 20, 346–378. doi:10.3762/bjoc.20.35
• Cao, W.; Wang, Z.; Hao, Y.; Wang, T.; Fu, S.; Liu, B. Total Synthesis of Sculponin U through a Photoinduced Radical Cascade Cyclization. Angewandte Chemie 2023, 135. doi:10.1002/ange.202305516
• Cao, W.; Wang, Z.; Hao, Y.; Wang, T.; Fu, S.; Liu, B. Total Synthesis of Sculponin U through a Photoinduced Radical Cascade Cyclization. Angewandte Chemie (International ed. in English) 2023, 62, e202305516. doi:10.1002/anie.202305516
• Kourgiantaki, M.; Bagkavou, G. G.; Stathakis, C. I.; Zografos, A. L. Selective preparative 'oxidase phase' in sesquiterpenoids: the radical approach. Organic Chemistry Frontiers 2023, 10, 2095–2114. doi:10.1039/d3qo00314k

Explore citations to this article at