Trifluoromethyl ethers – synthesis and properties of an unusual substituent

Scholarly Works

• Chang, Z.; Garg, A.; Besset, T. Strategic advances in C-OCF3 bond transformations. Chemical communications (Cambridge, England) 2025, 61, 15329–15332. doi:10.1039/d5cc03991f
• Hosseinzadeh, Z.; Zhang, Q.; Gao, J.; Wang, Y.; Wang, Q.; Ren, G.; Liang, T.; Ma, Y.; Sun, W.-H. Fluoro- & trifluoromethoxy-modified bis(imino)pyridyliron chloride enhancing the activity and stability of vinyl polyethylenes. Dalton transactions (Cambridge, England : 2003) 2025, 54, 12590–12600. doi:10.1039/d5dt00837a
• Ni, S.; Qu, H.; Liu, D.; Yuan, L.; Li, M.; Zhao, W. Recent advances of the mechanistic target of rapamycin (mTOR) inhibitors for drug discovery. European journal of medicinal chemistry 2025, 298, 118046. doi:10.1016/j.ejmech.2025.118046
• Zhu, Z.; Xu, Y.; Kyriazakos, S.; Prakash, G. K. S. Nucleophilic Trifluoromethoxylation of Benzyl Bromides via Carbonyl Diimidazole. European Journal of Organic Chemistry 2025, 28. doi:10.1002/ejoc.202500529
• Novás, M.; Matos, M. J. The Role of Trifluoromethyl and Trifluoromethoxy Groups in Medicinal Chemistry: Implications for Drug Design. Molecules (Basel, Switzerland) 2025, 30, 3009. doi:10.3390/molecules30143009
• Al Ahmad, A. R.; Maris, T.; Wuest, J. D. ArOCF3, ArOCHF2, ArOCH2F, and ArOCH3: What the F Does to Control the Crystallization of Riluzole and Analogous Fluoromethyl Ethers. Crystal Growth & Design 2025, 25, 6408–6420. doi:10.1021/acs.cgd.5c00831
• Zoghi‐Paydar, F.; Derakhshideh, M.; Azimi, M.; Ebadi, A.; Chehardoli, G.; Faramarzi, M. A.; Mojtabavi, S.; Mahdavi, M.; Najafi, Z. Novel Resorcinol‐Based 2‐Amino‐4H‐chromene‐3‐carbonitrile Derivatives as α‐Glucosidase Inhibitors: Synthesis, In Vitro Evaluation, and Molecular Dynamics Simulation Studies. Asian Journal of Organic Chemistry 2025, 14. doi:10.1002/ajoc.202500430
• Yang, P.; Chen, S.; Lu, J.; Ning, P.; Zhao, W.; Luan, Y.-X.; Chen, L.; Xu, X.; Tang, P. Silver-Catalyzed syn-Stereoselective Trifluoromethoxylation of Bicyclo[1.1.0]butanes. Organic letters 2025, 27, 7679–7684. doi:10.1021/acs.orglett.5c02396
• Liu, M.; Sun, M.; Ma, Y.; Wang, Y.; Li, M.; Sun, W.-H. Trifluoromethoxy- and Fluorobenzhydryl-Tuned Nickel Catalysts for Polyethylene Elastomers. Molecules (Basel, Switzerland) 2025, 30, 2706. doi:10.3390/molecules30132706
• Ayoup, M. S.; Mamdouh, E.; Soliman, S. M.; Elghamry, I.; Nafie, M. S.; Negm, A.; Sonousi, A.; Kassab, A. E.; Awad, L. F. Impact of trifluoromethyl Ugi adducts as anticancer agents: EGFR inhibition, apoptosis induction and miRNA up-regulation. RSC advances 2025, 15, 19530–19545. doi:10.1039/d5ra01428j
• Thedford, J.; Sanford, M. S. Mechanistic Organometallic Studies Drive Reagent Selection and Catalyst Design for the Palladium-Catalyzed Trifluoromethylthiolation of Aryl Electrophiles. Organometallics 2025, 44, 1210–1216. doi:10.1021/acs.organomet.5c00148
• Al Ahmad, A. R.; Maris, T.; Wuest, J. D. Hiding in Plain Sight: Polymorphs of Riluzole. Crystal Growth & Design 2025, 25, 3029–3036. doi:10.1021/acs.cgd.5c00089
• Zhou, S.; Zhang, L.; Zou, L.; Ayubi, B. I.; Wang, Y. Deterioration mechanism of fluorinated colorless polyimide and polysilazane reinforcement under atomic oxygen erosion. Progress in Organic Coatings 2025, 200, 108962. doi:10.1016/j.porgcoat.2024.108962
• Hosseinzadeh, Z.; Zhang, Q.; Wang, Q.; Muhammad Ashfaq, A.; Liang, T.; Ma, Y.; Sun, W.-H. Multifluoro-Modification Enhancing Catalytic Activity and Thermal Stability of Bis(imino)pyridylcobalt Chlorides for Linear Polyethylene. ChemPlusChem 2025, 90, e202500007. doi:10.1002/cplu.202500007
• Kraemer, Y.; Stephens, A. M.; Buldt, J. A.; Young, A.; McLoughlin, C. P.; Fettinger, J. C.; Holder, L. M.; Pitts, C. R. Strain-release trifluoromethoxylation and pentafluorosulfanoxylation of [1.1.0]bicyclobutanes: expanded access to fluorinated cyclobutane hybrid bioisosteres. Chemical communications (Cambridge, England) 2025, 61, 3159–3162. doi:10.1039/d4cc06616b
• Podgorski, M. N.; Martínez-Castro, L.; Bruning, J. B.; Campbell, E. C.; Maréchal, J.-D.; Bell, S. G. Investigating the Correlation between Product Release and Solvation in Cytochrome P450 Enzymes. ACS Catalysis 2025, 15, 2867–2884. doi:10.1021/acscatal.4c05873
• Meier, T.; Lorenzen, S.; Knuplez, T.; Preitschopf, T.; Koppe, K.; Barthen, P.; Bertermann, R.; Schulte, M.; Ignat'ev, N.; Finze, M. 2-Trifluoromethoxyacetic acid – Synthesis and characterization. Journal of Fluorine Chemistry 2025, 282, 110396. doi:10.1016/j.jfluchem.2025.110396
• Protti, S. Trihalides. Reference Module in Chemistry, Molecular Sciences and Chemical Engineering; Elsevier, 2025. doi:10.1016/b978-0-443-31482-7.00050-3
• Altaf, M. B.; Luan, Y.-X.; Tang, P. Recent advances in silver-mediated/catalyzed synthesis of trifluoromethoxy compounds. Science China Chemistry 2024, 68, 1717–1730. doi:10.1007/s11426-024-2342-4
• Logvinenko, I. G.; Sadkova, I. V.; Tolmachova, N. A.; Shishkina, S. V.; Daniliuc, C. G.; Haufe, G.; Kondratov, I. S. 4-Trifluoromethoxy proline: synthesis of stereoisomers and lipophilicity study. Organic & biomolecular chemistry 2024, 22, 7982–7988. doi:10.1039/d4ob00688g

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