Organo-fluorine chemistry

  1. editorImage
  1. Editor: Prof. David O'Hagan
    University of St Andrews

The introduction of fluorine into organic molecules is widely practised particularly when tuning the properties of molecules for specialist functions. Fluorine substitution finds a prominent role in pharmaceutical development, in governing bioactivity in a wide range of agrochemical products, in soft materials chemistry such as liquid crystals, in photoresist polymers, self assembling monolayers and in positron emission tomography. Allied to this breadth of activity is a steady development in the number and range of fluorination reagents and methods. The changes in behaviour of a molecule after the introduction of a fluorine atom continue to be unpredictable, and understanding such behaviour remains a driver in organo-fluorine research. Contributions to this series come from an international grouping of noted experts in fluorine chemistry, covering a wide range of topics, including the chemistry of trifluoromethyl compounds, the enantioselective synthesis of organo-fluorine compounds, the synthesis of fluorinated derivatives of natural products and the preparation of organo-fluorine compounds by Michael addition.

See also the Thematic Series:
Organo-fluorine chemistry III
Organo-fluorine chemistry II

See organo-fluorine videos at Beilstein TV.

  • Editorial
  • Published 25 Apr 2008

Beilstein J. Org. Chem. 2008, 4, No. 11, doi:10.3762/bjoc.4.11

  • Full Research Paper
  • Published 25 Apr 2008

  • PDF

  • Supp. Info

Beilstein J. Org. Chem. 2008, 4, No. 12, doi:10.3762/bjoc.4.12

Trifluoromethyl ethers – synthesis and properties of an unusual substituent

  1. Frédéric R. Leroux,
  2. Baptiste Manteau,
  3. Jean-Pierre Vors and
  4. Sergiy Pazenok
  • Review
  • Published 29 Apr 2008

  • PDF

Beilstein J. Org. Chem. 2008, 4, No. 13, doi:10.3762/bjoc.4.13

DBFOX- Ph/metal complexes: Evaluation as catalysts for enantioselective fluorination of 3-(2-arylacetyl)-2-thiazolidinones

  1. Takehisa Ishimaru,
  2. Norio Shibata,
  3. Dhande Sudhakar Reddy,
  4. Takao Horikawa,
  5. Shuichi Nakamura and
  6. Takeshi Toru
  • Preliminary Communication
  • Published 20 May 2008

Beilstein J. Org. Chem. 2008, 4, No. 16, doi:10.3762/bjoc.4.16

Efficient 1,4-addition of α-substituted fluoro(phenylsulfonyl)methane derivatives to α,β-unsaturated compounds

  1. G. K. Surya Prakash,
  2. Xiaoming Zhao,
  3. Sujith Chacko,
  4. Fang Wang,
  5. Habiba Vaghoo and
  6. George A. Olah
  • Full Research Paper
  • Published 21 May 2008

Beilstein J. Org. Chem. 2008, 4, No. 17, doi:10.3762/bjoc.4.17

  • Full Research Paper
  • Published 27 May 2008

Beilstein J. Org. Chem. 2008, 4, No. 18, doi:10.3762/bjoc.4.18

Synthesis of new triazole- based trifluoromethyl scaffolds

  1. Michela Martinelli,
  2. Thierry Milcent,
  3. Sandrine Ongeri and
  4. Benoit Crousse
  • Preliminary Communication
  • Published 29 May 2008

Beilstein J. Org. Chem. 2008, 4, No. 19, doi:10.3762/bjoc.4.19

  • Full Research Paper
  • Published 26 Jun 2008

Beilstein J. Org. Chem. 2008, 4, No. 21, doi:10.3762/bjoc.4.21

  • Full Research Paper
  • Published 01 Jul 2008

Beilstein J. Org. Chem. 2008, 4, No. 22, doi:10.3762/bjoc.4.22

Synthesis of deep- cavity fluorous calix[4]arenes as molecular recognition scaffolds

  1. Maksim Osipov,
  2. Qianli Chu,
  3. Steven J. Geib,
  4. Dennis P. Curran and
  5. Stephen G. Weber
  • Full Research Paper
  • Published 20 Oct 2008

Beilstein J. Org. Chem. 2008, 4, No. 36, doi:10.3762/bjoc.4.36

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