Continuous flow based catch and release protocol for the synthesis of α-ketoesters

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• Liu, C.; Xie, J.; Wu, W.-B.; Wang, M.; Weihao, C.; Idres, S. B.; Rong, J.-W.; Deng, L.-W.; Khan, S. A.; Wu, J. Automated synthesis of prexasertib and derivatives enabled by continuous-flow solid-phase synthesis. Nature chemistry 2021, 13, 451–457. doi:10.1038/s41557-021-00662-w
• Dankers, C.; Tadros, J.; Harman, D. G.; Aldrich-Wright, J. R.; Nguyen, T. V.; Gordon, C. P. Immobilized carbodiimide assisted flow combinatorial protocol to facilitate amide coupling and lactamization. ACS combinatorial science 2020, 22, 255–267. doi:10.1021/acscombsci.0c00001
• Cornils, B. doi:10.1002/9783527809080.cataz18017
• Sloby, C. doi:10.1002/9783527809080.cataz03191
• Hoffmeyer, P.; Schneider, C. Continuous Flow Synthesis of Highly Substituted Tetrahydrofurans. European Journal of Organic Chemistry 2019, 2019, 5326–5333. doi:10.1002/ejoc.201900421
• Chiurchiù, E.; Patehebieke, Y.; Gabrielli, S.; Ballini, R.; Palmieri, A. β‐Nitroacrylates as Starting Materials of Thiophene‐2‐Carboxylates Under Continuous Flow Conditions. Advanced Synthesis & Catalysis 2019, 361, 2042–2047. doi:10.1002/adsc.201801660
• Gabrielli, S.; Chiurchiù, E.; Palmieri, A. β-Nitroacrylates: A Versatile and Growing Class of Functionalized Nitroalkenes. Advanced Synthesis & Catalysis 2018, 361, 630–653. doi:10.1002/adsc.201800709
• Neyt, N. C.; Riley, D. L. Batch–flow hybrid synthesis of the antipsychotic clozapine. Reaction Chemistry & Engineering 2018, 3, 17–24. doi:10.1039/c7re00146k
• Yadav, M. B.; Kulkarni, S.; Joshi, R. A.; Kulkarni, A. A. Continuous Flow Doebner–Miller Reaction and Isolation Using Continuous Stirred Tank Reactors. Organic Process Research & Development 2016, 20, 1621–1625. doi:10.1021/acs.oprd.6b00179
• Glasnov, T. N. Continuous-Flow Chemistry in the Research Laboratory - Organic Synthesis in Dedicated Continuous Flow Systems: Further Chemistry Examples. Continuous-Flow Chemistry in the Research Laboratory; Springer International Publishing, 2016; pp 93–112. doi:10.1007/978-3-319-32196-7_10
• Gabrielli, S.; Ciabattoni, L.; Sampaolesi, S.; Ballini, R.; Palmieri, A. A new fully heterogeneous synthesis of pyrrole-2-acetic acid derivatives. RSC Advances 2016, 6, 44341–44344. doi:10.1039/c6ra05348c
• Eftekhari-Sis, B.; Zirak, M. Chemistry of α-oxoesters: a powerful tool for the synthesis of heterocycles. Chemical reviews 2014, 115, 151–264. doi:10.1021/cr5004216
• Ager, D. J. ACS Symposium Series - Managing Hazardous Reactions and Compounds in Process Chemistry. ACS Symposium Series; American Chemical Society, 2014; pp 285–351. doi:10.1021/bk-2014-1181.ch012
• Fagnoni, M.; Bonassi, F.; Palmieri, A.; Protti, S.; Ravelli, D.; Ballini, R. Flow Synthesis of Substituted γ-Lactones by Consecutive Photocatalytic/Reductive Reactions. Advanced Synthesis & Catalysis 2014, 356, 753–758. doi:10.1002/adsc.201300859
• Baxendale, I. R. The integration of flow reactors into synthetic organic chemistry. Journal of Chemical Technology & Biotechnology 2013, 88, 519–552. doi:10.1002/jctb.4012
• Gabrielli, S.; Ballini, R.; Palmieri, A. β-Nitroacrylates as key building blocks for the synthesis of alkyl 3-substituted 5-oxopiperazine-2-carboxylates under fully heterogeneous conditions. Monatshefte für Chemie - Chemical Monthly 2013, 144, 509–514. doi:10.1007/s00706-012-0895-1
• Deadman, B. J.; Battilocchio, C.; Sliwinski, E.; Ley, S. V. A prototype device for evaporation in batch and flow chemical processes. Green Chemistry 2013, 15, 2050–2055. doi:10.1039/c3gc40967h
• Nakano, Y.; Savage, G. P.; Saubern, S.; Scammells, P. J.; Polyzos, A. A Multi-Step Continuous Flow Process for the N-Demethylation of Alkaloids. Australian Journal of Chemistry 2013, 66, 178–182. doi:10.1071/ch12463
• Palmieri, A.; Gabrielli, S.; Ballini, R. Low impact synthesis of β-nitroacrylates under fully heterogeneous conditions. Green Chemistry 2013, 15, 2344–2348. doi:10.1039/c3gc40936h
• Gabrielli, S.; Palmieri, A.; Panmand, D. S.; Lanari, D.; Vaccaro, L.; Ballini, R. β-Nitroacrylates as key starting materials for the one-pot synthesis of densely functionalized penta-substituted anilines. Tetrahedron 2012, 68, 8231–8235. doi:10.1016/j.tet.2012.07.065

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