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Automated synthesis of sialylated oligosaccharides

Davide Esposito, Mattan Hurevich, Bastien Castagner, Cheng-Chung Wang and Peter H. Seeberger

Beilstein J. Org. Chem. 2012, 8, 1601–1609. https://doi.org/10.3762/bjoc.8.183

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Supporting Information File 1: Experimental procedure and characterization data for new compounds.
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Supporting Information File 2: ¹H and ¹³C NMR spectra for new compounds.
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Automated synthesis of sialylated oligosaccharides

Davide Esposito, Mattan Hurevich, Bastien Castagner, Cheng-Chung Wang and Peter H. Seeberger

Beilstein J. Org. Chem. 2012, 8, 1601–1609. https://doi.org/10.3762/bjoc.8.183

How to Cite

Esposito, D.; Hurevich, M.; Castagner, B.; Wang, C.-C.; Seeberger, P. H. Beilstein J. Org. Chem. 2012, 8, 1601–1609. doi:10.3762/bjoc.8.183

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TY  - JOUR
A1  - Esposito, Davide
A1  - Hurevich, Mattan
A1  - Castagner, Bastien
A1  - Wang, Cheng-Chung
A1  - Seeberger, Peter H.
T1  - Automated synthesis of sialylated oligosaccharides
JF  - Beilstein Journal of Organic Chemistry
PY  - 2012///
VL  - 8
SP  - 1601
EP  - 1609
SN  - 1860-5397
DO  - 10.3762/bjoc.8.183
PB  - Beilstein-Institut
JA  - Beilstein J. Org. Chem.
UR  - https://doi.org/10.3762/bjoc.8.183
KW  - automated synthesis
KW  - disaccharide building blocks
KW  - solid-phase synthesis
KW  - sialic acid
KW  - sialosides
N2  - Sialic acid-containing glycans play a major role in cell-surface interactions with external partners such as cells and viruses. Straightforward access to sialosides is required in order to study their biological functions on a molecular level. Here, automated oligosaccharide synthesis was used to facilitate the preparation of this class of biomolecules. Our strategy relies on novel sialyl α-(2→3) and α-(2→6) galactosyl imidates, which, used in combination with the automated platform, provided rapid access to a small library of conjugation-ready sialosides of biological relevance.
ER  -

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