Chemical–biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target

Jonathan W. Choy, Clifford Bryant, Claudia M. Calvet, Patricia S. Doyle, Shamila S. Gunatilleke, Siegfried S. F. Leung, Kenny K. H. Ang, Steven Chen, Jiri Gut, Juan A. Oses-Prieto, Jonathan B. Johnston, Michelle R. Arkin, Alma L. Burlingame, Jack Taunton, Matthew P. Jacobson, James M. McKerrow, Larissa M. Podust and Adam R. Renslo
Beilstein J. Org. Chem. 2013, 9, 15–25. https://doi.org/10.3762/bjoc.9.3

Supporting Information

The Supporting Information features a table with experimentally determined and computationally predicted binding affinities, additional GC/MS spectra from lipid-analysis studies, time courses for reaction of compounds 1 and 6 with glutathione in vitro, and synthetic schemes for analogues 4, 9, 11, 12, and 13, as well as experimental procedures.

Supporting Information File 1: Figures, schemes, and experimental procedures.
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Chemical–biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target
Jonathan W. Choy, Clifford Bryant, Claudia M. Calvet, Patricia S. Doyle, Shamila S. Gunatilleke, Siegfried S. F. Leung, Kenny K. H. Ang, Steven Chen, Jiri Gut, Juan A. Oses-Prieto, Jonathan B. Johnston, Michelle R. Arkin, Alma L. Burlingame, Jack Taunton, Matthew P. Jacobson, James M. McKerrow, Larissa M. Podust and Adam R. Renslo
Beilstein J. Org. Chem. 2013, 9, 15–25. https://doi.org/10.3762/bjoc.9.3

How to Cite

Choy, J. W.; Bryant, C.; Calvet, C. M.; Doyle, P. S.; Gunatilleke, S. S.; Leung, S. S. F.; Ang, K. K. H.; Chen, S.; Gut, J.; Oses-Prieto, J. A.; Johnston, J. B.; Arkin, M. R.; Burlingame, A. L.; Taunton, J.; Jacobson, M. P.; McKerrow, J. M.; Podust, L. M.; Renslo, A. R. Beilstein J. Org. Chem. 2013, 9, 15–25. doi:10.3762/bjoc.9.3

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