Synthetic probes for the study of biological function

  1. editorImage
  1. Editor: Prof. Jeffrey Aubé
    University of Kansas

From its beginnings, organic chemistry has been a partner to biology, often crossing the artificial boundary between the sciences to the benefit of both disciplines. As the field has matured, it has continued to address matters of structure and synthesis to increasingly encompass the grand challenge of designing and preparing molecules having a particular function. All three of these come together in the pursuit of new chemical probes for use in chemical biology. This Thematic Series highlights some of the numerous ways that molecular tools inform biological research. The structural diversity of molecules that function as probes is broad indeed, some of them complex enough that even the most discerning practitioner of organic synthesis may consider them as worthy of their efforts.

  • Editorial
  • Published 15 Jan 2013

Beilstein J. Org. Chem. 2013, 9, 79–80, doi:10.3762/bjoc.9.10

  • Full Research Paper
  • Published 20 Sep 2012

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Beilstein J. Org. Chem. 2012, 8, 1584–1593, doi:10.3762/bjoc.8.181

  • Full Research Paper
  • Published 08 Oct 2012

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Beilstein J. Org. Chem. 2012, 8, 1705–1709, doi:10.3762/bjoc.8.194

  • Full Research Paper
  • Published 11 Dec 2012

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Beilstein J. Org. Chem. 2012, 8, 2156–2165, doi:10.3762/bjoc.8.243

Chemical–biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target

  1. Jonathan W. Choy,
  2. Clifford Bryant,
  3. Claudia M. Calvet,
  4. Patricia S. Doyle,
  5. Shamila S. Gunatilleke,
  6. Siegfried S. F. Leung,
  7. Kenny K. H. Ang,
  8. Steven Chen,
  9. Jiri Gut,
  10. Juan A. Oses-Prieto,
  11. Jonathan B. Johnston,
  12. Michelle R. Arkin,
  13. Alma L. Burlingame,
  14. Jack Taunton,
  15. Matthew P. Jacobson,
  16. James M. McKerrow,
  17. Larissa M. Podust and
  18. Adam R. Renslo
  • Full Research Paper
  • Published 04 Jan 2013

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Beilstein J. Org. Chem. 2013, 9, 15–25, doi:10.3762/bjoc.9.3

Thioester derivatives of the natural product psammaplin A as potent histone deacetylase inhibitors

  1. Matthias G. J. Baud,
  2. Thomas Leiser,
  3. Vanessa Petrucci,
  4. Mekala Gunaratnam,
  5. Stephen Neidle,
  6. Franz-Josef Meyer-Almes and
  7. Matthew J. Fuchter
  • Letter
  • Published 15 Jan 2013

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Beilstein J. Org. Chem. 2013, 9, 81–88, doi:10.3762/bjoc.9.11

  • Full Research Paper
  • Published 15 Jan 2013

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Beilstein J. Org. Chem. 2013, 9, 89–96, doi:10.3762/bjoc.9.12

Asymmetric synthesis of host-directed inhibitors of myxoviruses

  1. Terry W. Moore,
  2. Kasinath Sana,
  3. Dan Yan,
  4. Pahk Thepchatri,
  5. John M. Ndungu,
  6. Manohar T. Saindane,
  7. Mark A. Lockwood,
  8. Michael G. Natchus,
  9. Dennis C. Liotta,
  10. Richard K. Plemper,
  11. James P. Snyder and
  12. Aiming Sun
  • Full Research Paper
  • Published 30 Jan 2013

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Beilstein J. Org. Chem. 2013, 9, 197–203, doi:10.3762/bjoc.9.23

  • Review
  • Published 30 Jan 2013

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Beilstein J. Org. Chem. 2013, 9, 204–214, doi:10.3762/bjoc.9.24

A new synthetic protocol for coumarin amino acid

  1. Xinyi Xu,
  2. Xiaosong Hu and
  3. Jiangyun Wang
  • Full Research Paper
  • Published 06 Feb 2013

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Beilstein J. Org. Chem. 2013, 9, 254–259, doi:10.3762/bjoc.9.30

From bead to flask: Synthesis of a complex β-amido-amide for probe-development studies

  1. Kevin S. Martin,
  2. Cristian Soldi,
  3. Kellan N. Candee,
  4. Hiromi I. Wettersten,
  5. Robert H. Weiss and
  6. Jared T. Shaw
  • Full Research Paper
  • Published 06 Feb 2013

Beilstein J. Org. Chem. 2013, 9, 260–264, doi:10.3762/bjoc.9.31

Synthesis and evaluation of cell-permeable biotinylated PU-H71 derivatives as tumor Hsp90 probes

  1. Tony Taldone,
  2. Anna Rodina,
  3. Erica M. DaGama Gomes,
  4. Matthew Riolo,
  5. Hardik J. Patel,
  6. Raul Alonso-Sabadell,
  7. Danuta Zatorska,
  8. Maulik R. Patel,
  9. Sarah Kishinevsky and
  10. Gabriela Chiosis
  • Full Research Paper
  • Published 15 Mar 2013

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Beilstein J. Org. Chem. 2013, 9, 544–556, doi:10.3762/bjoc.9.60

  • Review
  • Published 15 Apr 2013

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Beilstein J. Org. Chem. 2013, 9, 717–732, doi:10.3762/bjoc.9.82

Synthesis and physicochemical characterization of novel phenotypic probes targeting the nuclear factor-kappa B signaling pathway

  1. Paul M. Hershberger,
  2. Satyamaheshwar Peddibhotla,
  3. E. Hampton Sessions,
  4. Daniela B. Divlianska,
  5. Ricardo G. Correa,
  6. Anthony B. Pinkerton,
  7. John C. Reed and
  8. Gregory P. Roth
  • Full Research Paper
  • Published 08 May 2013

Beilstein J. Org. Chem. 2013, 9, 900–907, doi:10.3762/bjoc.9.103

Isotopically labeled sulfur compounds and synthetic selenium and tellurium analogues to study sulfur metabolism in marine bacteria

  1. Nelson L. Brock,
  2. Christian A. Citron,
  3. Claudia Zell,
  4. Martine Berger,
  5. Irene Wagner-Döbler,
  6. Jörn Petersen,
  7. Thorsten Brinkhoff,
  8. Meinhard Simon and
  9. Jeroen S. Dickschat
  • Full Research Paper
  • Published 15 May 2013

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Beilstein J. Org. Chem. 2013, 9, 942–950, doi:10.3762/bjoc.9.108

  • Letter
  • Published 21 May 2013

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Beilstein J. Org. Chem. 2013, 9, 966–973, doi:10.3762/bjoc.9.111

  • Review
  • Published 24 May 2013

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Beilstein J. Org. Chem. 2013, 9, 991–1001, doi:10.3762/bjoc.9.114

  • Full Research Paper
  • Published 27 May 2013

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  • Video

Beilstein J. Org. Chem. 2013, 9, 1002–1011, doi:10.3762/bjoc.9.115

Amyloid-β probes: Review of structure–activity and brain-kinetics relationships

  1. Todd J. Eckroat,
  2. Abdelrahman S. Mayhoub and
  3. Sylvie Garneau-Tsodikova
  • Review
  • Published 28 May 2013

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Beilstein J. Org. Chem. 2013, 9, 1012–1044, doi:10.3762/bjoc.9.116

ML212: A small-molecule probe for investigating fluconazole resistance mechanisms in Candida albicans

  1. Willmen Youngsaye,
  2. Cathy L. Hartland,
  3. Barbara J. Morgan,
  4. Amal Ting,
  5. Partha P. Nag,
  6. Benjamin Vincent,
  7. Carrie A. Mosher,
  8. Joshua A. Bittker,
  9. Sivaraman Dandapani,
  10. Michelle Palmer,
  11. Luke Whitesell,
  12. Susan Lindquist,
  13. Stuart L. Schreiber and
  14. Benito Munoz
  • Full Research Paper
  • Published 26 Jul 2013

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Beilstein J. Org. Chem. 2013, 9, 1501–1507, doi:10.3762/bjoc.9.171

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