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Beilstein J. Org. Chem. 2026, 22, 1160–1167, doi:10.3762/bjoc.22.93
Graphical Abstract
Scheme 1: Unexpected outcome of the reaction of diethyl chloro(phenyl)methylphosphonate (2) with PDPP followe...
Scheme 2: Unexpected outcome of the reaction of (sulfonyloxy)(phenyl)methylphosphonate 5 with PDPP followed b...
Scheme 3: Putative explanation for the formation of compounds 6–8 shown in Scheme 2.
Scheme 4: Result of the attempted chloro-substitution of hydroxy(phenyl)methylphosphine oxide 14a.
Scheme 5: Two pathways (methods A and B) for the preparation of (diarylphosphinyl)(aryl)methyl diphenylphosph...
Scheme 6: Unexpected route following the mesylation of (hydroxy(4-methoxyphenyl)methyl)(diphenyl)phosphine ox...
Figure 1: In vitro antiproliferative effects of compounds tested at 10 and 100 µM on U266 cell line after 72 ...