2 article(s) from Champagne, Pier Alexandre
Graphical Abstract
Figure 1: C–F activation of benzylic fluorides to generate benzylamine or diarylmethane products.
Figure 2: 7-[2H1]-(R)-Benzyl fluoride ((R)-1).
Scheme 1: Synthesis of enantioenriched 7-[2H1]-(R)-benzyl fluoride ((R)-1) from benzaldehyde (2).
Figure 3: Partial 2H{1H} NMR (107.5 MHz) with PBLG in CHCl3 (13% w/w). (A) racemic sample of 6 (from Table 1, entry ...
Scheme 2: Synthesis of enantioenriched (S)-diarylmethane 10 from diaryl ketone 11 and confirmation of configu...
Figure 4: Possible reactive intermediates for C–F activation of benzyl fluoride 1 with strong hydrogen bond d...
Graphical Abstract
Figure 1: SN2 reaction of activated alkyl fluorides and calculated transition state for the reaction of morph...
Figure 2: Proposed activation of C–F bonds mediated by a triol.