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Beilstein J. Org. Chem. 2024, 20, 1518–1526, doi:10.3762/bjoc.20.136
Graphical Abstract
Figure 1: Selected examples of drugs and bioactive molecules bearing a pyrazole core.
Scheme 1: Representative examples of asymmetric organocatalytic conjugate addition of pyrazolin-5-ones to α,β...
Scheme 2: Scope of substrates. Reaction conditions: 1 (0.3 mmol), 2 (0.2 mmol), 15 mol % of catalyst I, 30 mo...
Scheme 3: Synthesis of pyrazole-benzofuran and pyrazole–indole hybrid molecules. Reaction conditions: 1m or 1n...
Scheme 4: Synthesis of 3aa on preparative scale.
Figure 2: Single crystal X-ray structure of ent-3ba (CCDC 2234286).
Scheme 5: Proposed reaction mechanism.
Beilstein J. Org. Chem. 2021, 17, 2642–2649, doi:10.3762/bjoc.17.177
Scheme 1: Selected methods for the synthesis of enantioenriched β-silyl nitroalkanes, synthesis of chiral org...
Scheme 2: Scope of substrates. Reaction conditions: 1 (0.2 mmol), 2 (0.5 mmol), catalyst VII (0.01 mmol, 5 mo...
Scheme 3: Synthesis of ent-3. Reaction conditions: 1 (0.2 mmol), 2 (0.5 mmol), catalyst VIII (0.01 mmol, 5 mo...
Scheme 4: Organocatalytic 1,4-conjuagte addition of nitromethane (2) to enone 3o.
Figure 1: Single crystal X-ray structure of ent-3k (CCDC 2097263).
Scheme 5: Preparative scale synthesis of 3c and ent-3d.