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1 article(s) from Drachuk, Andrew S

Spirobarbiturates with a pyrrolizidine moiety: synthesis, structure and biological evaluation

Arthur A. Puzyrkov,
Andrew S. Drachuk,
Ekaterina A. Popova,
Alexander V. Stepakov and
Vitali M. Boitsov

Beilstein J. Org. Chem. 2026, 22, 274–288, doi:10.3762/bjoc.22.20

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Scheme 1: Biologically active compounds with a spirobarbiturate moiety in their structure [7-12].

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Scheme 2: Biologically active alkaloids with a pyrrolizidine moiety.

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Scheme 3: Previous studies on the three-component synthesis of spirobarbiturates.

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Scheme 4: Synthesis of racemic spirobarbiturates 4a–p via one-pot three-component reaction of alloxan (1), ʟ-...

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Scheme 5: A plausible mechanism of spirobarbiturate formation from alloxan (1), ʟ-proline (2), and N-substitu...

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Figure 1: Schematic structures of endo- and exo-adducts of spirobarbiturates 4.

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Figure 2: X-ray crystal structures of compounds 4b (CCDC 2391172, left) and 4c (CCDC 2391171, right).

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Figure 3: Unit cell packing of products 4b (left) and 4c (right).

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Figure 4: HS mapped with d_norm for compounds 4b (left) and 4c (right).

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Figure 5: A segment of the crystal structure of compound 4b with the HS (d_norm), showing intermolecular conta...

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Figure 6: A segment of the crystal structure of compound 4c with the HS (d_norm), showing intermolecular conta...

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Figure 7: Microscopic images of treated cells and state of the actin cytoskeleton of Sk-mel-2 cells after cul...

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Figure 8: Docked view of compounds 4f, 4g, 4i, 4k, and 4l with the target protein (PDB ID: 8DNH).

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Published 17 Feb 2026

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