This search combines search strings from the content search (i.e. "Full Text", "Author", "Title", "Abstract", or "Keywords") with "Article Type" and "Publication Date Range" using the AND operator.
Beilstein J. Org. Chem. 2025, 21, 2716–2729, doi:10.3762/bjoc.21.209
Graphical Abstract
Figure 1: Structures of bioactive molecules with trifluoromethylpyridine and piperidine frameworks.
Scheme 1: The reaction of ethyl trifluoroacetoacetate (1), acetone (2a) and 1,3- diaminopropan-2-ol (3).
Scheme 2: Three-component reaction of ethyl trifluoroacetoacetate (1), alkyl methyl ketones 2b,c and 1,3-diam...
Scheme 3: Three-component reaction of ethyl trifluoroacetoacetate (1), acetophenone (2d) and 1,3-diaminopropa...
Scheme 4: The proposed mechanism of three-component cyclization of 3-oxo ester 1, methyl ketones 2a–d and 1,3...
Figure 2: ORTEP view of compounds 4асc (a, CCDC: 2479553), 4аct (b, CCDC: 2479554), 4аtt (c, CCDC: 2479555), ...
Figure 3: ORTEP view of compound 5ctc (a, CCDC: 2479558), 5ctt (b, CCDC: 2479559) showing with the thermal el...
Figure 4: The fragments of the 1H NMR spectra (400 MHz, DMSO-d6) of diastereomers 4acc (a), 4аct (b), 4аtt (c...
Figure 5: Fragments of 1H NMR spectra (400 MHz, DMSO-d6) of hexahydrooxazolo[3,2-a]pyridin-5-ones 5ctc (a) an...
Beilstein J. Org. Chem. 2015, 11, 385–391, doi:10.3762/bjoc.11.44
Scheme 1: Interaction of 2-ethoxymethylidene-3-oxo esters 1a–c with 5-AT. R = CF3 (a), (CF2)2H (b), Me (c). C...
Scheme 2: Synthesis of pyrimidines 4a,b and 5. R= CF3 (a), (CF2)2H (b). Conditions: i: 1,4-dioxane, NaOAc, Δ,...
Figure 1: X-ray crystal structure of compound 5 (ORTEP drawing, 50% probability level).
Scheme 3: Interaction of 2-ethoxymethylidene malonate 1e with 5-AT. Conditions: i: EtOH, Et3N, Δ; ii: EtOH, Δ....
Scheme 4: The reaction of 3-oxo ester 1d with 5-AT. Conditions, i: TFE, Δ, 48 h.
Scheme 5: Interaction of ester 1f with 5-AT. Conditions i: EtOH (or TFE), Et3N, Δ, 40–60 min; ii: AcOH (or Et...
Figure 2: X-ray crystal structure of compound 11 (ORTEP drawing, 50% probability level).