3 article(s) from Hodgkinson, James T
- Letter
- Published 19 Oct 2018
-
PDF -
Album-
![]()
Graphical Abstract
-
![]()
Figure 1: A family of quinolone natural products 1–8, which were first isolated from Pseudonocardia sp. CL384...
-
![]()
Scheme 1: Proposed use of the chemistry developed towards the total synthesis of 5 and 6 for generation of na...
-
![]()
Scheme 2: Sonagashira coupling of alkynes 10a and 10b with commercially available acid chloride 9 to give yno...
-
![]()
Scheme 3: Conjugate addition of primary amines 12a–f with ynones 11a and 11b. aFollowing concentration in vac...
-
![]()
Scheme 4: Cyclisation of precursors 13 to natural product analogues 14 using palladium- or copper-catalysed c...
-
![]()
Scheme 5: Use of an excess of DMEDA in the Cu-catalysed cyclisation of 13bb resulted in the generation of 14bg...
-
![]()
Figure 2: Growth of E. coli ESS with time in the presence of 200 μM of each compound. A) Natural product seri...
-
![]()
Figure 3: Growth of S. aureus 25923 with time in the presence of 200 μM of each compound. A) Natural product ...
-
![]()
Figure 4: OD520 (absorption corresponding to pyocyanin) normalised by the culture population (measured by OD6...
-
-
Supp. Info
- Letter
- Published 16 Oct 2018
-
PDF -
Album-
![]()
Graphical Abstract
-
![]()
Figure 1: NDH-2 is a validated target for 1 with an MIC of 1.1 µg/mL against M. tuberculosis.
-
![]()
Scheme 1: Synthesis of phenothiazine-PEG-amine component.
-
![]()
Scheme 2: Synthesis of the azotochelin siderophore component.
-
![]()
Scheme 3: Final conjugation and deprotection to yield a phenothiazine siderophore conjugate.
-
-
Supp. Info
- Letter
- Published 11 Jul 2016
-
PDF -
Album-
![]()
Graphical Abstract
-
![]()
Figure 1: BHL and OdDHL are two natural AHL-based signaling molecules used by P. aeruginosain quorum sensing....
-
![]()
Scheme 1: Unexpected synthesis of compound 4. The synthesis of 2 was achieved by a previously reported route [9]....
-
![]()
Figure 2: a) Inhibitory effect of compound 4 (200 μM suspension in DMSO) on pyocyanin production in PAO1. DMS...
-
![]()
Figure 3: Binding poses of OdDHL and compound 4 in OdDHL binding site. Hydrogen bonds are shown in black dott...
-
-
Supp. Info
